Abstract:
:It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a double-blind, randomized, cross-over design to contrast the effects of 6 weeks treatment with alpha-methyldopa and the combination of hydrochlorothiazide and amiloride with that of amlodipine and the combined diuretics in a group of 24 newly diagnosed patients with primary hypertension. All-night polysomnography was performed before the initiation of therapy (baseline) and at the end of the two treatment periods. Respiratory variables failed to reveal any significant differences between the treatments and baseline, or between the two different treatment regimens. The two treatment regimens achieved similar reductions in blood pressure. The prevalence of SAH was 25% before treatment, which is comparable to a prevalence of 20% in a similar group drawn from the same population but receiving various antihypertensive medications. The findings of this study are in agreement with previous reports using other classes of antihypertensive drugs that also failed to detect any tendency for increases in nocturnal respiratory disturbance indices over assessment periods of 8 weeks or shorter.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Bartel PR,Loock M,Becker P,Robinson E,van der Meyden C,Rossouw Sdoi
10.1016/s0895-7061(96)00507-9subject
Has Abstractpub_date
1997-06-01 00:00:00pages
640-5issue
6eissn
0895-7061issn
1941-7225pii
S0895-7061(96)00507-9journal_volume
10pub_type
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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