Abstract:
:To clarify characteristics of the patients in whom exercise training lowers blood pressure and to elucidate the mechanisms by which exercise training lowers blood pressure, we evaluated 24-h blood pressure, glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA), plasma aldosterone concentration (PAC), plasma norepinephrine concentration (PNE), and incremental area of insulin/glucose (sigmaI/sigmaG) during 75 g oral glucose tolerance test, and assessed arterial baroreceptor function (BSI) before and after a 3-week exercise training program (four 6-min sessions daily at 75% VO2 max). Patients were classified as responders (n = 15) if they showed statistically significant reduction in the multiple comparison of 24-h mean arterial pressure (MAP), or as nonresponders (n = 15) if they did not. Although there were no significant differences between responders and nonresponders in age, weight, MAP, GFR, RBF, RPF, FF, PNE, sigmaI/sigmaG, or BSI before exercise, renal vascular resistance (RVR; P < .05), PRA (P < .05), and PAC (P < .05) were significantly higher in responders than in nonresponders. The fractional excretion of sodium (FENa) (P < .05) were significantly lower in responders than in nonresponders. After exercise training, FF (P < .01), RVR (P < .05), PNE (P < .05) PRA (P < .01), and sigmaI/sigmaG (P < .05) decreased significantly only in responders. The decrease in MAP significantly correlated with the reductions in FF (r = 0.46, P < .05), PNE (r = 0.52, P < .01) and RVR (r = 0.40, P < .05). Thus, in patients who have higher RVR and PRA, exercise training lowered blood pressure in parallel to a reduction in RVR associated with decreases in sympathetic tone and improvement of insulin resistance. Our results suggest that exercise-induced changes in renal hemodynamics may contribute to the reduction in blood pressure in these patients.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Kohno K,Matsuoka H,Takenaka K,Miyake Y,Nomura G,Imaizumi Tdoi
10.1016/s0895-7061(97)00109-xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
859-68issue
8eissn
0895-7061issn
1941-7225pii
S0895-7061(97)00109-Xjournal_volume
10pub_type
临床试验,杂志文章abstract::During the course of a long-term, prospective, randomized study in 77 hypertensive nephrosclerosis patients, five patients developed evidence suggestive of renal artery stenosis. However, arteriography demonstrated patent renal arteries. The evidence suggestive of renal artery stenosis was: (1) converting-enzyme inhib...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajh/2.5.349
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,评审
doi:10.1093/ajh/2.12.313s
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journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.amjhyper.2005.10.005
更新日期:2006-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ajh/3.11.846
更新日期:1990-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/2.1.57
更新日期:1989-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00041-7
更新日期:1998-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-11 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.03.015
更新日期:2007-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.06.016
更新日期:2005-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(99)00021-7
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.286
更新日期:2008-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajh/3.12.903
更新日期:1990-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/s0895-7061(00)01249-8
更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ajh/3.7.533
更新日期:1990-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 历史文章,杂志文章
doi:10.1016/s0895-7061(99)00212-5
更新日期:2000-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/4.7.565
更新日期:1991-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1016/0895-7061(96)00054-4
更新日期:1996-08-01 00:00:00