Endogenous marinobufagenin-like immunoreactive substance. A possible endogenous Na, K-ATPase inhibitor with vasoconstrictor activity.

abstract：:High dietary Na+ raises mean arterial pressure (MAP) by more than 10% in salt-sensitive (SS) patients with essential hypertension. To test whether the rise in MAP in these patients is caused by a Na(+)-linked increase in [Ca2+]i in vascular smooth muscle cells, we measured [Ca2+]i in the lymphocytes of 14 patients wit...

journal_title：American journal of hypertension

authors： Alexiewicz JM,Gaciong Z,Parise M,Karubian F,Massry SG,Campese VM

更新日期：1992-08-01 00:00:00

abstract：:Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

journal_title：American journal of hypertension

authors： Fedorova OV,Anderson DE,Bagrov AY

更新日期：1998-07-01 00:00:00

abstract：:Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium. Moreover, in the absence of vascular endothelium, bradykinin also inhibits n...

journal_title：American journal of hypertension

authors： Greenberg SS,Peevy K,Tanaka TP

更新日期：1991-05-01 00:00:00

abstract：:The purpose of this study was to determine whether cold-stress stimulation to the soles of paws produces continuous hypertension in rats. Wistar-Kyoto rats were kept in cages with a 0 degrees C floor and 23 degrees C room temperature (cold-stressed group, n = 10) or in cages with 23 degrees C floor and 23 degrees C ro...

journal_title：American journal of hypertension

authors： Kanayama N,Khatun S,Belayet H,She L,Terao T

更新日期：1999-11-01 00:00:00

abstract：:Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...

journal_title：American journal of hypertension

authors： Tuck ML,Bravo EL,Krakoff LR,Friedman CP

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

journal_title：American journal of hypertension

authors： Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

更新日期：2017-05-01 00:00:00

abstract：:Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their no...

journal_title：American journal of hypertension

authors： Sechi LA,Griffin CA,Zingaro L,Catena C,De Carli S,Schambelan M,Bartoli E

更新日期：1997-11-01 00:00:00

abstract：:The aim of this study was to assess whether an interaction exists between the renin-angiotensin system and the sympathetic nervous system at the level of the adrenal medulla during insulin-induced hypoglycemia in normal humans. Seventeen healthy volunteers were studied in a randomized, single-dose, double-blind, cross...

journal_title：American journal of hypertension

authors： Madsen BK,Hølmer P,Ibsen H,Christensen NJ

更新日期：1992-06-01 00:00:00

abstract：AIMS:Several studies have indicated that low physical activity is associated with increased risk of cardiovascular disease (CVD) and all-cause mortality among patients with diabetes. The association between physical activity and subclinical cardiovascular changes preceding clinical events remains to be elucidated. We i...

journal_title：American journal of hypertension

authors： Funck KL,Laugesen E,Høyem P,Fleischer J,Cichosz SL,Christiansen JS,Hansen TK,Poulsen PL

更新日期：2016-07-01 00:00:00

abstract：:The current study tested the hypothesis that centrally administered relaxin elevates arterial pressure in conscious rats and that this hypertensive effect is mediated, at least in part, by central or peripheral vasopressin. Injection of human relaxin (0.068 or 0.34 microgram in 200 nL artificial cerebrospinal fluid) i...

journal_title：American journal of hypertension

authors： Yang RH,Bunting S,Wyss JM,Berecek KH,Zhang L,Jin H

更新日期：1995-04-01 00:00:00

abstract：:To determine whether the benefits of antihypertensive treatment vary according to dipper status, 811 asymptomatic elderly Japanese hypertensives underwent 24-h ambulatory blood pressure monitoring. During a mean follow-up period of 41 months, 32 stroke events were observed in patients who remained nonmedicated (n = 38...

journal_title：American journal of hypertension

authors： Hoshide Y,Kario K,Schwartz JE,Hoshide S,Pickering TG,Shimada K

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:We hypothesized that high-dose active vitamin D therapy in the form of alphacalcidol (α-calcidol), used to treat secondary hyperparathyroidism in chronic kidney disease, could lead to vascular calcification and accelerated progression of aortic stiffness. METHODS:We conducted an observational study in 85 pa...

journal_title：American journal of hypertension

authors： Fortier C,Mac-Way F,De Serres SA,Marquis K,Douville P,Desmeules S,Larivière R,Agharazii M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

journal_title：American journal of hypertension

authors： Sankaralingam S,Desai KM,Wilson TW

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Sympathetic activation occurs in hypertension (HT) and after acute myocardial infarction (AMI) and is related to greater cardiovascular risk. Also, AMI in patients with HT (AMI-HT) carries greater risk than that in normal subjects (AMI-NT). We therefore planned to determine whether the sympathetic activation...

journal_title：American journal of hypertension

authors： Hogarth AJ,Mackintosh AF,Mary DA

更新日期：2006-10-01 00:00:00

abstract：:Although left ventricular hypertrophy (LVH) is an adaptive response to the increased load imposed on the heart in patients with hypertension, it ultimately is itself a major risk factor for cardiovascular disease. The influence of LVH on left ventricular function and on the coronary circulation, and the occurrence of ...

journal_title：American journal of hypertension

authors： Clement DL,De Buyzere M,Duprez D

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...

journal_title：American journal of hypertension

authors： Hare JL,Sharman JE,Leano R,Jenkins C,Wright L,Marwick TH

更新日期：2013-05-01 00:00:00

abstract：:After nephrectomy, the level of arterial pressure is determined by the permitted degree of fluid volume expansion. With kidneys present, the fundamental requirement for fluid volume homeostasis is met by maintaining the balance between sodium and water intake and output. When one-kidney, one-clip (1-K,1-C) hypertensio...

journal_title：American journal of hypertension

authors： Ledingham JM

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Hypertension (HTN) is a known major cardiovascular disease risk factor, but prevalence, treatment, and control of HTN among rapidly growing minority groups such as Asian Americans and Hispanics are unknown largely due to either underrepresentation in epidemiologic studies or aggregation of Asian American sub...

journal_title：American journal of hypertension

authors： Zhao B,Jose PO,Pu J,Chung S,Ancheta IB,Fortmann SP,Palaniappan LP

更新日期：2015-05-01 00:00:00

abstract：:In normal coronary arteries, increased flow velocity induces endothelium-dependent dilation, and dilation in response to sympathetic stimulation evoked by the cold pressor test is partly due to increased flow velocity. In arterial hypertension, angiographically normal coronary arteries were constricted by acetylcholin...

journal_title：American journal of hypertension

authors： Nitenberg A,Antony I,Aptecar E,Arnoult F,Lerebours G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 ...

journal_title：American journal of hypertension

authors： Meyer TE,Shiffman D,Morrison AC,Rowland CM,Louie JZ,Bare LA,Ross DA,Arellano AR,Chasman DI,Ridker PM,Pankow JS,Coresh J,Malloy MJ,Kane JP,Ellis SG,Devlin JJ,Boerwinkle E

更新日期：2009-02-01 00:00:00

abstract：:Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

journal_title：American journal of hypertension

authors： Kahn AM,Allen JC,Seidel CL,Song T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally...

journal_title：American journal of hypertension

authors： Nishizaka MK,Pratt-Ubunama M,Zaman MA,Cofield S,Calhoun DA

更新日期：2005-06-01 00:00:00

abstract：:Body sodium works together with the plasma renin-angiotensin system to ensure adequate blood flow to the tissues. Body sodium content determines the extracellular fluid (ECF) volume ensuring that, with each heart beat, a sufficient volume of fluid is delivered into the arterial space. At the same time the kidneys moni...

journal_title：American journal of hypertension

authors： Laragh JH,Sealey JE

更新日期：2011-11-01 00:00:00

abstract：:Previous studies have shown that erythrocytes from the Milan hypertensive strain of rats (MHS) differ from erythrocytes from the control normotensive strain (MNS). These differences are determined within the stem cells, are genetically associated with the development of hypertension, and are similar to those found bet...

journal_title：American journal of hypertension

authors： Salardi S,Saccardo B,Borsani G,Modica R,Ferrandi M,Tripodi MG,Soria M,Ferrari P,Baralle FE,Sidoli A

更新日期：1989-04-01 00:00:00

abstract：:The most common reason for an outpatient physician visit is for the diagnosis and treatment of hypertension. The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC) VII, which is increasingly evidence-based, advises the clinician to use studies of the mean response...

journal_title：American journal of hypertension

authors： Graves JW,Sheps SG

更新日期：2004-04-01 00:00:00

abstract：:Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...

journal_title：American journal of hypertension

authors： Goodfriend TL

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

journal_title：American journal of hypertension

authors： Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

journal_title：American journal of hypertension

authors： Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear. METHODS:We followed 2649 initially untreated subjects with essential hypertension for up to 16 years (mean, 6). Variability of BP was estimated by the standard d...

journal_title：American journal of hypertension

authors： Verdecchia P,Angeli F,Gattobigio R,Rapicetta C,Reboldi G

更新日期：2007-02-01 00:00:00

abstract：:Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient. Magnetic resonance imaging (MRI) may be a more precise and reliable method to quantify the mass of the left ventricule. This study reports the accuracy,...

journal_title：American journal of hypertension

authors： Bottini PB,Carr AA,Prisant LM,Flickinger FW,Allison JD,Gottdiener JS

更新日期：1995-03-01 00:00:00