Abstract:
BACKGROUND:Sympathetic activation occurs in hypertension (HT) and after acute myocardial infarction (AMI) and is related to greater cardiovascular risk. Also, AMI in patients with HT (AMI-HT) carries greater risk than that in normal subjects (AMI-NT). We therefore planned to determine whether the sympathetic activation and its duration after AMI are greater in patients with antecedent HT than in patients with normal arterial pressure (NT). METHODS:In 68 matched subjects with uncomplicated AMI-HT (n = 17), AMI-NT (n = 17), HT (n = 17), and NT (n = 17), we measured resting muscle sympathetic nerve activity (MSNA) as the mean frequency of multiunit bursts (m-MSNA) and single units (s-MSNA). In AMI groups data were obtained 2 to 4 days after AMI and then at 3-month intervals until MSNA returned to levels found in HT and NT. RESULTS:The AMI-HT had greater (at least P < 0.05; ANOVA) s-MSNA (99 +/- 3.5 impulses/100 cardiac beats) than AMI-NT (84 +/- 2.8 impulses/100 cardiac beats). During follow up, s-MSNA hyperactivity in AMI-HT was always greater than in AMI-NT, and returned to values found in HT and NT (84 +/- 3.5 impulses/100 cardiac beats and 62 +/- 4.4 impulses/100 cardiac beats, respectively) 9 months after AMI. Similar results were obtained for m-MSNA. CONCLUSIONS:AMI in hypertensives resulted in greater MSNA levels lasting at least 6 months longer than AMI in normotensives. This indicates that AMI further augmented the MSNA hyperactivity of HT and that this could be one mechanism involved in the reported worse prognosis in AMI-HT.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Hogarth AJ,Mackintosh AF,Mary DAdoi
10.1016/j.amjhyper.2006.03.015subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1070-6issue
10eissn
0895-7061issn
1941-7225pii
S0895-7061(06)00257-3journal_volume
19pub_type
杂志文章abstract::The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/3.8.210
更新日期:1990-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2004-05-01 00:00:00
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doi:10.1093/ajh/6.6.480
更新日期:1993-06-01 00:00:00
abstract::Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean ag...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-10-01 00:00:00
abstract::Post-transplant hypertension remains an important risk factor for cardiovascular mortality and graft function. There are multiple mechanisms responsible for post-transplant hypertension. The details of these mechanisms are poorly understood. Steroids, acute and chronic rejection, recurrent renal disease, native kidney...
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pub_type: 杂志文章,评审
doi:10.1093/ajh/3.9.721
更新日期:1990-09-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2000-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.7.618
更新日期:1991-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.08.020
更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
abstract::In normal subjects, insulin decreases the urinary excretion of sodium, potassium, and uric acid. We tested whether these renal effects of insulin are altered in insulin resistant hypertension. In 37 patients with essential hypertension, we measured the changes in urinary excretion of sodium, potassium, and uric acid i...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:There are no comprehensive guidelines on management of hypertensive emergency (HTNE) and complications. Despite advances in antihypertensive medications HTNE is accompanied with significant morbidity and mortality. METHODS:We queried the 2002-2012 nationwide inpatient sample database to identify patients wi...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpx048
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear. METHODS:We followed 2649 initially untreated subjects with essential hypertension for up to 16 years (mean, 6). Variability of BP was estimated by the standard d...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.07.017
更新日期:2007-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.154
更新日期:2008-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/4.10.534s
更新日期:1991-10-01 00:00:00
abstract::We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the develop...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(99)00267-8
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.41
更新日期:2008-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2010.69
更新日期:2010-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2012.3
更新日期:2012-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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更新日期:1992-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.293
更新日期:2008-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpy049
更新日期:2018-05-07 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00256-8
更新日期:1999-04-01 00:00:00
abstract::Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.3.234
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Pregnancy-induced hypertension (PIH) is associated with chronic hypertension (HTN) and cardiovascular complications. We investigated the factors that predict the development of chronic HTN in women with PIH. METHODS:The study population comprised 108 women with PIH and 87 healthy age-matched women control s...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpv073
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa021
更新日期:2020-04-29 00:00:00