Abstract:
BACKGROUND:The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear. METHODS:We followed 2649 initially untreated subjects with essential hypertension for up to 16 years (mean, 6). Variability of BP was estimated by the standard deviation of daytime or night-time systolic BP (SBP) and diastolic BP (DBP). A BP variability either less than or equal to the group median or greater than the group median (12.7/10.4 mm Hg for daytime SBP/DBP and 10.8 and 8.9 mm Hg for night-time SBP/DBP) identified subjects at low or high BP variability. RESULTS:During follow-up there were 167 new cardiac and 122 new cerebrovascular events. The rate of cardiac events (x100 person-years) was higher (all P < .05) in the subjects with high than in those with low BP variability (daytime SBP: 1.45 v 0.72, daytime DBP: 1.29 v 0.91; night-time SBP: 1.58 v 0.62; night-time DBP: 1.32 v 0.85). The rate of cerebrovascular events was also higher (all P < .05) in the subjects with high than in those with low BP variability. In a multivariate analysis, after adjustment for several confounders, a high night-time SBP variability was associated with a 51% (P = .024) excess risk of cardiac events. The relation of daytime BP variability to cardiac events and that of daytime and night-time BP variability to cerebrovascular events lost significance in the multivariate analysis. CONCLUSIONS:An enhanced variability in SBP during the night-time is an independent predictor of cardiac events in initially untreated hypertensive subjects.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Verdecchia P,Angeli F,Gattobigio R,Rapicetta C,Reboldi Gdoi
10.1016/j.amjhyper.2006.07.017subject
Has Abstractpub_date
2007-02-01 00:00:00pages
154-61issue
2eissn
0895-7061issn
1941-7225pii
S0895-7061(06)00508-5journal_volume
20pub_type
杂志文章abstract::The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...
journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0895-7061(97)00320-8
更新日期:1997-12-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-09 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ajh/7.11.948
更新日期:1994-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/0895-7061(95)00354-1
更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0895-7061(95)00018-K
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