Twenty-four-hour blood pressure control with isradipine in mild essential hypertension.

Abstract:

:The hypotensive effect of isradipine was assessed in 26 male patients, aged 40 to 64 years, with hypertension. After withdrawal of previous antihypertensive treatment and a four-week placebo period, patients were randomized into a double-blind active-treatment period of eight weeks to receive either placebo or 1.25 to 2.5 mg isradipine twice daily. Twenty-four-hour ambulatory blood pressure was measured by Accutracker (Suntech, Oxford, England) after the placebo period and at the end of the active-treatment period. In the isradipine group n = 13), both systolic and diastolic blood pressure and number of blood pressure spikes decreased significantly (P less than .0001), whereas there was a significant increase of these variables in the placebo control group (n = 13). The results of this study indicate that, in these subjects, blood pressure control was achieved throughout the 24-h period by monotherapy with isradipine.

journal_name

Am J Hypertens

authors

Viskoper JR,Laszt A,Faraggi D

doi

10.1093/ajh/4.2.161s

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

161S-162S

issue

2 Pt 2

eissn

0895-7061

issn

1941-7225

journal_volume

4

pub_type

临床试验,杂志文章,随机对照试验
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