Abstract:
BACKGROUND:Subjects with renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypothesized that superimposition of MetS induces myocardial mitochondrial damage, leading to cardiac injury and dysfunction in swine RVH. METHODS:Pigs were studied after 16 weeks of diet-induced MetS with or without RVH (unilateral renal artery stenosis), and Lean controls (n=6 each). Systolic and diastolic cardiac function were assessed by multi-detector CT, and cardiac mitochondrial morphology (transmission electron microscopy) and myocardial function in tissue and isolated mitochondria. RESULTS:Body weight was similarly higher in MetS groups vs. Lean. RVH groups achieved significant stenosis and developed hypertension. Mitochondrial matrix density and ATP production were lower and H2O2 production higher in RVH groups versus Lean and MetS. Lean+RVH (but not MetS+RVH) activated mitophagy, which was associated with decreased myocardial expression of mitophagy-related microRNAs. MetS groups exhibited higher numbers of inter-mitochondrial junctions (IMJs), which could have prevented membrane depolarization/activation of mitophagy in MetS+RVH. Cardiac fibrosis, hypertrophy (increased left ventricular muscle mass), and diastolic function (decreased E/A ratio) were greater in MetS+RVH versus Lean+RVH. CONCLUSIONS:Superimposition of MetS on swine RVH induces myocardial mitochondrial damage and dysfunction. MetS+RVH failed to activate mitophagy, resulting in greater cardiac remodeling, fibrosis, and diastolic dysfunction. Mitochondrial injury and impaired mitophagy may constitute important mechanisms and potential therapeutic targets to ameliorate cardiac damage and dysfunction in patients with coexisting MetS and RVH.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Aghajani Nargesi A,Farah MC,Zhu XY,Zhang L,Tang H,Jordan KL,Saadiq IM,Lerman A,Lerman LO,Eirin Adoi
10.1093/ajh/hpaa202subject
Has Abstractpub_date
2020-12-05 00:00:00eissn
0895-7061issn
1941-7225pii
6024518pub_type
杂志文章abstract:BACKGROUND:The relationship between regular physical activity, measured objectively and by self-report, and the circadian pattern of 24-hour ambulatory arterial blood pressure (BP) has not been clarified. METHODS:We performed a cross-sectional study in a cohort of healthy patients. We included 1,345 patients from the ...
journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
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journal_title:American journal of hypertension
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abstract::It has been suggested that atheroma formation is a chronic inflammatory response to lipid-derived inflammatory mediators accumulating at selected arterial sites. At large artery flow dividers and curvatures, secondary flow phenomena create zones of stagnation and recirculation that deprive endothelial cells of shear s...
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
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更新日期:1995-05-01 00:00:00
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journal_title:American journal of hypertension
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pub_type: 杂志文章,评审
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
abstract::Conflicting reports exist as to whether air traffic controllers (ATC) have an increase in blood pressure (BP) and prevalence of hypertension because of the stressful nature of their job. We have addressed the issue in male ATC working at the Linate airport of Milan. A total of 80 ATC participated, and the 24 h blood p...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(97)00321-x
更新日期:1998-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa037
更新日期:2020-07-18 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpz015
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. METHODS:Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2011.262
更新日期:2012-04-01 00:00:00