Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives.

abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...

journal_title：American journal of hypertension

authors： Wimalawansa SJ

更新日期：1993-12-01 00:00:00

abstract：:Decreased urinary kallikrein excretion has been shown to be related to hypertension. Kallikrein levels also have been shown to be determined primarily by genes, with 51% of the total variance being due to a single gene. However, there exists strong spouse-spouse correlation, indicating that common environment plays a ...

journal_title：American journal of hypertension

authors： Hunt SC,Wu LL,Slattery ML,Meikle AW,Williams RR

更新日期：1993-03-01 00:00:00

abstract：:Angiotensin II (Ang II) and transforming growth factor-beta (TGF-beta) modulate cell growth and metabolism. Our objective was to evaluate the effect of Ang II on the characteristics and expression of TGF-beta receptors on vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats. The addition of TGF-beta1 elicited a ...

journal_title：American journal of hypertension

authors： Fukuda N,Hu WY,Kubo A,Kishioka H,Satoh C,Soma M,Izumi Y,Kanmatsuse K

更新日期：2000-02-01 00:00:00

abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

journal_title：American journal of hypertension

authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Considering sex differences, salt sensitivity, and insulin resistance (IR), the effect of sodium restriction and increased potassium intake on blood pressure remains unclear in normotensive Asian individuals, compared to that in hypertensive patients. METHODS:To assess the influence of sodium and potassium ...

journal_title：American journal of hypertension

authors： Murao S,Takata Y,Yasuda M,Osawa H,Kohi F

更新日期：2018-07-16 00:00:00

abstract：:The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

journal_title：American journal of hypertension

authors： Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a ...

journal_title：American journal of hypertension

authors： Pankow JS,Dunn DM,Hunt SC,Leppert MF,Miller MB,Rao DC,Heiss G,Oberman A,Lalouel JM,Weiss RB

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

journal_title：American journal of hypertension

authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The expression of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in spontaneously hypertensive rat (SHR). We investigated whether expression of NKCC1 is epigenetically regulated during postnatal development of hypertension. METHODS:The mesenteric arteries from 5-, 10-, and 18-week-old Wistar-Kyoto...

journal_title：American journal of hypertension

authors： Cho HM,Lee HA,Kim HY,Han HS,Kim IK

更新日期：2011-12-01 00:00:00

abstract：:The importance of the level to which blood pressure is reduced becomes increasingly important when one considers preservation of renal function. It is clear that three major subsets of patients emerge as requiring levels of blood pressure control of < 130/85 mm Hg to preserve renal function. Such individuals include b...

journal_title：American journal of hypertension

authors： Bakris GL

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Liddle's syndrome (LS) is a monogenic form of hypertension simulating a mineralocorticoid excess, and is currently suspected in young hypokalemic hypertensives. The aims of the study were: (i) to evaluate the clinical phenotype of LS in a newly identified Italian family of Sicilian origin carrying a gain-of-...

journal_title：American journal of hypertension

authors： Rossi E,Farnetti E,Nicoli D,Sazzini M,Perazzoli F,Regolisti G,Grasselli C,Santi R,Negro A,Mazzeo V,Mantero F,Luiselli D,Casali B

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated. METHOD...

journal_title：American journal of hypertension

authors： Haruhara K,Tsuboi N,Kanzaki G,Koike K,Suyama M,Shimizu A,Miyazaki Y,Kawamura T,Ogura M,Yokoo T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...

journal_title：American journal of hypertension

authors： Pierdomenico SD,Pierdomenico AM,Di Tommaso R,Coccina F,Di Carlo S,Cuccurullo F,Porreca E

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...

journal_title：American journal of hypertension

authors： Brosnan MJ,Carkner RD

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor family that has been implicated in cell differentiation and proliferation, glucose metabolism, macrophage development, and inflammatory responses. PPAR-gamma can be activated by a range of synthetic substances a...

journal_title：American journal of hypertension

authors： Limor R,Sharon O,Knoll E,Many A,Weisinger G,Stern N

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Pulse pressure/stroke volume indexed to height(2.04) (PP/SVi) is a validated measure of arterial stiffness, but its relation to carotid atherosclerosis is unknown. METHODS:Clinical, echocardiographic, and carotid ultrasound data from 6,209 hypertensive patients without prevalent cardiovascular (CV) disease ...

journal_title：American journal of hypertension

authors： Casalnuovo G,Gerdts E,de Simone G,Izzo R,De Marco M,Giudice R,Trimarco B,De Luca N

更新日期：2012-07-01 00:00:00

abstract：:In essential hypertension (EHT) the presence of a metabolic syndrome increases the risk of cardiovascular disease. A cell membrane abnormality is implicated but its role in cardiovascular disease is unclear. Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinfl...

journal_title：American journal of hypertension

authors： Fardon NJ,Wilkinson R,Thomas TH

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and...

journal_title：American journal of hypertension

authors： Xu X,Su S,Treiber FA,Vlietinck R,Fagard R,Derom C,Gielen M,Loos RJ,Snieder H,Wang X

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...

journal_title：American journal of hypertension

authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

更新日期：2000-10-01 00:00:00

abstract：:We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...

journal_title：American journal of hypertension

authors： Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

更新日期：1991-12-01 00:00:00

abstract：:To evaluate potential physiological actions of atrial natriuretic peptide (ANP) in humans, normal male volunteers were studied in the supine and head-up tilt positions both in the absence and presence of an ANP infusion at a rate which increased plasma ANP levels to ranges observed during physiological stimuli such as...

journal_title：American journal of hypertension

authors： Grandis DJ,Uretsky BF,Ray SM,Vassilaros L,Verbalis JG,Puschett JB

更新日期：1991-03-01 00:00:00

abstract：AIMS:Several studies have indicated that low physical activity is associated with increased risk of cardiovascular disease (CVD) and all-cause mortality among patients with diabetes. The association between physical activity and subclinical cardiovascular changes preceding clinical events remains to be elucidated. We i...

journal_title：American journal of hypertension

authors： Funck KL,Laugesen E,Høyem P,Fleischer J,Cichosz SL,Christiansen JS,Hansen TK,Poulsen PL

更新日期：2016-07-01 00:00:00

abstract：:The purpose of this study was to determine whether antihypertensive therapy with the angiotensin converting enzyme inhibitor lisinopril would alter cell Na+ transport kinetics, metabolic parameters associated with insulin resistance, or both in young adults with mild hypertension. Sixteen young adults (mean age 29 +/-...

journal_title：American journal of hypertension

authors： Falkner B,Canessa M,Anzalone D

更新日期：1995-05-01 00:00:00

abstract：:High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...

journal_title：American journal of hypertension

authors： Tobian L,Jahner TM,Johnson MA

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:All renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin-angiotensin-aldosterone activity. We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone. MET...

journal_title：American journal of hypertension

authors： Tu W,Eckert GJ,Pratt JH,Jan Danser AH

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) concentric geometry and hypertrophy, depressed wall mechanics, and abnormal diastolic properties have been described in the diabetic heart. However, the cardiac response to dynamic exercise in diabetic patients remains controversial. The present study assessed strain rate (SR) imaging d...

journal_title：American journal of hypertension

authors： Galderisi M,de Simone G,Innelli P,Turco A,Turco S,Capaldo B,Riccardi G,de Divitiis O

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance...

journal_title：American journal of hypertension

authors： Finkielman JD,Schwartz GL,Chapman AB,Boerwinkle E,Turner ST

更新日期：2005-03-01 00:00:00

abstract：:Endothelin-1, discovered in 1988, is a 21-amino-acid peptide and currently the most potent vasoconstrictor and pressor substance known. Generated by vascular endothelial cells in response to a variety of chemical and mechanical signals, endothelin-1 is known to potentiate the actions of other vasoconstrictor substance...

journal_title：American journal of hypertension

authors： Webb DJ,Strachan FE

更新日期：1998-04-01 00:00:00

abstract：:To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...

journal_title：American journal of hypertension

authors： Lawrence DL,Shenker Y

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone (PTH) stimulates aldosterone secretion in human adrenocortex and is regulated by the renin-angiotensin-aldosterone system. We speculated that measurement of PTH may be a valuable aid in the diagnosis of aldosterone-producing adenoma (APA). METHODS:To test this hypothesis, we recruited 14...

journal_title：American journal of hypertension

authors： Zhang LX,Gu WJ,Li YJ,Wang Y,Wang WB,Wang AP,Shen L,Zang L,Yang GQ,Lu ZH,Dou JT,Mu YM

更新日期：2016-05-01 00:00:00