Abstract：
:We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow was 231 +/- 29 mL/min pre and 244 +/- 35 mL/min posttherapy. The filtration fraction (0.24 pre; 0.23 post) and the renal vascular resistance (492 +/- 144 pre; 422 +/- 101 post) also remained stable with verapamil therapy. Blood pressure was lower after treatment (P less than .02) in 7 of 10 patients. Urinary albumin excretion was reduced only when blood pressure was lowered. Verapamil had a modest effect on the renin-aldosterone axis. While the mean increase in plasma renin activity from a pretreatment value of 1.8 +/- 0.42 ng/mL/h to 2.1 +/- 0.56 ng/mL/h failed to reach statistical significance, the increases in urinary aldosterone excretion from 8.2 +/- 2.2 mg/24 h to 11.1 +/- 2.3 mg/24 h did (P less than .001). Our results demonstrate that verapamil lowered blood pressure without renal hemodynamic compromise in hypertensive patients with chronic renal disease. The antihypertensive response was associated with a rise in urinary aldosterone excretion, with unchanged serum electrolytes. We conclude that verapamil is effective, safe, and well-tolerated in patients with renal impairment and hypertension, and may be suitable for clinical trials evaluating long-term progression of renal disease.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Lenz T,Müller FB,Sotelo JE,Laragh JH,August Pdoi
10.1093/ajh/4.12.939subject
Has Abstractpub_date
1991-12-01 00:00:00pages
939-43issue
12 Pt 1eissn
0895-7061issn
1941-7225journal_volume
4pub_type
杂志文章abstract：:Angiotensin II (Ang II) and transforming growth factor-beta (TGF-beta) modulate cell growth and metabolism. Our objective was to evaluate the effect of Ang II on the characteristics and expression of TGF-beta receptors on vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats. The addition of TGF-beta1 elicited a ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00152-1
更新日期：2000-02-01 00:00:00
abstract：:To evaluate the existence of a relationship between atrial natriuretic factor (ANF) and plasma Na+/K+ATPase inhibitory activity in humans, we examined the hemodynamic and humoral response to volume expansion in 41 borderline hypertensive patients (BHT) with either normal (n = 33) or low plasma renin activity (n = 8). ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/4.7.618
更新日期：1991-07-01 00:00:00
abstract：:Intranasal administration of some peptides has been shown to directly influence central nervous functions, thus pointing to a nose-brain pathway for these substances in humans. The present study investigated whether intranasal administration of angiotensin II (ANG II) affects central nervous functions of cardiovascula...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(98)00095-8
更新日期：1998-08-01 00:00:00
abstract：:This double-blind placebo controlled study investigated the antihypertensive and humoral effects of nifedipine capsules in patients with essential hypertension inadequately controlled (seated diastolic blood pressure greater than or equal to 95 mm Hg) by hydrochlorothiazide (HCTZ) alone. Nifedipine acutely (first dose...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/2.11.828
更新日期：1989-11-01 00:00:00
abstract：:The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to sur...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.3.234
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:The aims of this study were to document the presence of phospholipase C (PLC) isozymes beta(1), gamma(1), and delta(1) in freshly isolated renal glomeruli and resistance vessels, to compare their expression and activity to that in aorta, and to contrast values between 6-week-old Wistar-Kyoto (WKY) controls a...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.06.009
更新日期：2007-01-01 00:00:00
abstract：:In order to examine the relationship existing between dietary calcium and the development of hypertension, we developed a long-term study in the Lyon hypertensive rat strain (LH) and two control strains, the Lyon normotensive (LN) and low blood pressure rats (LL) given enriched (HCa, 2.5%), deprived (LCa, 0.03%) and n...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.11.846
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:During the development of hypertension, glucose replaces triacylglycerols (TG) as the main energy source for the myocardium. However, there are no available studies investigating the TG molecular species composition of the myocardium in the spontaneously hypertensive rat (SHR). The objective of this study wa...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.11.012
更新日期：2005-01-01 00:00:00
abstract：:In the present study we examined whether the angiotensin I converting enzyme inhibitor, captopril, would protect stroke-prone spontaneously hypertensive rats (SHRSP) from stroke and renal pathology over a 26-week period. In the control group of six untreated SHRSP fed Stroke-Prone Rodent Diet and 1% NaCl drinking solu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/4.8.680
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:Schlager inbred hypertensive mice (BPH/2J) have been suggested to have high blood pressure (BP) due to an overactive sympathetic nervous system (SNS). The brain nuclei associated with the hypertension are also those involved in the integration of the cardiovascular responses to stress. Therefore, in the pres...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.69
更新日期：2010-08-01 00:00:00
abstract：:The purpose of this study was to examine the variability of 24-hour urinary and serum creatinine levels and creatinine clearance in normal subjects and to develop nomograms for assessing the adequacy of 24-hour urine collections. The data were from a longitudinal research program examining biochemical, hormonal, and h...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/1.2.124
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:We have recently shown that the renin enhancer, a regulatory element of renin gene transcription, is important in the long-term control of basal blood pressure (BP). In this study, we examined whether the renin enhancer deficit alters the acute pressor response to emotional stress in mice. METHODS:Under flu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2007.02.010
更新日期：2007-08-01 00:00:00
abstract：:Kidney stones affect hypertensive patients disproportionately compared to normotensive individuals. On the other hand, some prospective data suggest that a history of nephrolithiasis was associated with a greater tendency to develop hypertension. Newer epidemiologic data also link obesity and diabetes, features of the...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1038/ajh.2007.62
更新日期：2008-03-01 00:00:00
abstract：:There is evidence that hyperinsulinemia and insulin resistance play a role in the development of hypertension. Accordingly, in our ongoing longitudinal study of pregnancy-induced hypertension, we have measured fasting levels of insulin and glucose at 18 to 25 weeks gestation in 140 nulliparous African-American women f...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(94)00166-9
更新日期：1995-01-01 00:00:00
abstract：:Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled, uncontrolled study was initiated in o...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/5.8.506
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.10.020
更新日期：2005-03-01 00:00:00
abstract：:Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02046-5
更新日期：2001-08-01 00:00:00
abstract：:Great pathophysiological significance has recently been placed on the association of metabolic abnormalities, such as hyperinsulinemia, insulin resistance, obesity, and frank diabetes mellitus, with essential hypertension and coronary artery disease, and the clinical coincidence of these features has been termed "synd...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/6.4s.123s
更新日期：1993-04-01 00:00:00
abstract：:Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00440-8
更新日期：1996-06-01 00:00:00
abstract：:We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activatio...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Home blood pressure measurement (HBPM) is recommended by hypertension guidelines, particularly in the elderly. However, feasibility of HBPM in this age group has not been fully established. Our objective was therefore to assess HBPM feasibility in elderly individuals of the general population. METHODS:After...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/ajh.2012.121
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The polymorphism of several candidate genes has been studied in relation to essential hypertension and cardiovascular complications. Target organ damage in essential hypertension is a complex disorder influenced by multiple genetic and environmental factors. The possible contribution of endothelin gene varia...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02162-8
更新日期：2001-08-01 00:00:00
abstract：:Among the major mechanisms controlling the renal release of renin, renal nerves are known to exert a direct stimulating action on juxtaglomerular cells that is mediated by beta-adrenoceptors. Activation of the renal nerves also exerts an important permissive role in order to amplify and possibly accelerate responses t...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/2.2.7s
更新日期：1989-02-01 00:00:00
abstract：:The treatment of diseases has been based on the concept of homeostasis and has not incorporated an understanding of biologic rhythms and their underlying mechanisms. Biologic rhythms are implicated in cardiovascular events. Failure to recognize the circadian decline in blood pressure may result in iatrogenic chronopat...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02173-2
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2007.34
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Aging is a major risk factor for the development of arterial stiffness and vascular disease, and it is related to the upregulation of matrix metalloproteinase-2 (MMP-2) in the aorta of rats and nonhuman primates. This study aimed to determine whether MMP activity in the human vasculature changes with aging. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.11.011
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ). METHODS:This was a randomized, double-blind,...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.amjhyper.2003.11.003
更新日期：2004-03-01 00:00:00
abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(02)02264-1
更新日期：2002-05-01 00:00:00
abstract：:This study was performed to investigate the role of endogenous epinephrine in the regulation of vascular tone in hypertension. The release of endogenous epinephrine and norepinephrine from the vascular adrenergic neurons by periarterial nerve stimulation was examined in spontaneously hypertensive rats (SHR) and age-ma...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.1.52
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function a...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.amjhyper.2004.08.036
更新日期：2005-02-01 00:00:00
