当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect.

Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect.

Abstract：

:In the present study we examined whether the angiotensin I converting enzyme inhibitor, captopril, would protect stroke-prone spontaneously hypertensive rats (SHRSP) from stroke and renal pathology over a 26-week period. In the control group of six untreated SHRSP fed Stroke-Prone Rodent Diet and 1% NaCl drinking solution, all animals developed severe hypertension and stroke by 16.1 weeks of age. In eight salt-loaded SHRSP treated with oral captopril (50 mg/kg/day) beginning at 8.4 weeks of age, systolic blood pressure was slightly but temporarily suppressed and then continued to rise; by 12 weeks of age systolic blood pressure reached levels of severe hypertension, 240 +/- 8 mm Hg, and did not differ from that of untreated SHRSP. No deaths or brain lesions were noted in captopril-treated SHRSP despite severe hypertension maintained through 26 weeks of age when the study ended. Captopril treatment prevented increases in urinary protein excretion (14 +/- 2 v 63 +/- 16 mg/day at 11.7 weeks of age, P less than .01) and the severe brain, renal, and cardiac vascular lesions observed in untreated SHRSP. When maintained on Stroke-Prone Rodent Diet and saline, plasma renin activity of untreated SHRSP surviving until 14.5 weeks of age was markedly increased (29.1 +/- 9.4 ng Ang I/mL/h) compared with either untreated SHRSP (9.2 +/- 2.5 ng Ang I/mL/h, P less than .01) or Wistar-Kyoto rats (3.5 +/- 1.0 ng Ang I/mL/h, P less than .01) maintained on standard diet and water.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Stier CT Jr,Chander P,Gutstein WH,Levine S,Itskovitz HD

doi

10.1093/ajh/4.8.680

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

680-7

issue

8

eissn

0895-7061

issn

1941-7225

journal_volume

4

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism.

    abstract：:Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.7.533

    authors： Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata K

    更新日期：1990-07-01 00:00:00

  • Inhibition of nitric oxide synthesis increases erythrocyte membrane fluidity and unsaturated fatty acid content.

    abstract：:Changes in the lipid composition of the membrane affect its fluidity and function. These variables are altered in various forms of hypertension. Our hypothesis was that the rapid increase in blood pressure (BP) caused by inhibition of nitric oxide production would lead to alterations in membrane fluidity similar to th...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01184-5

    authors： McLauren Dorrance A,Graham D,Dominiczak A,Fraser R

    更新日期：2000-11-01 00:00:00

  • Protective action of calcium channel antagonists in atherogenesis and experimental vascular injury.

    abstract：:Experimental research using in vitro and in vivo models of vascular injury have delineated several common mechanisms that characterize the arterial damage in diseases such as atherosclerosis and hypertension. Changes in endothelial permeability, smooth muscle cell proliferation, and accumulation of connective tissue m...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.3.205

    authors： Weinstein DB,Heider JG

    更新日期：1989-03-01 00:00:00

  • Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage.

    abstract：BACKGROUND:Components of the renin-angiotensin-aldosterone system (RAAS) and a prothrombotic state are predictors of cardiovascular events in hypertensive patients. A relationship between the RAAS and the coagulation/fibrinolytic systems has been demonstrated, but its clinical relevance in hypertension is unclear. We i...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.293

    authors： Sechi LA,Novello M,Colussi G,Di Fabio A,Chiuch A,Nadalini E,Casanova-Borca A,Uzzau A,Catena C

    更新日期：2008-12-01 00:00:00

  • Maternal Blood Pressure Before Pregnancy and Sex of the Baby: A Prospective Preconception Cohort Study.

    abstract：BACKGROUND:Population-level sociologic studies have suggested that adverse societal conditions may affect fetal viability in a sex-specific manner and thereby modify the ratio of male vs. female babies. This concept suggests that there may exist certain physiologic features in a woman that relate to her likelihood of d...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpw165

    authors： Retnakaran R,Wen SW,Tan H,Zhou S,Ye C,Shen M,Smith GN,Walker MC

    更新日期：2017-04-01 00:00:00

  • Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus.

    abstract：BACKGROUND:Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) i...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ajh/hpw146

    authors： Sardana M,Vasim I,Varakantam S,Kewan U,Tariq A,Koppula MR,Syed AA,Beraun M,Drummen NE,Vermeer C,Akers SR,Chirinos JA

    更新日期：2017-02-01 00:00:00

  • Efficacy and safety of angiotensin receptor blockers in older patients: a meta-analysis of randomized trials.

    abstract：BACKGROUND:The efficacy and safety of angiotensin receptor blockers (ARBs) in the older population is unclear. OBJECTIVES:To determine the efficacy and safety of ARBs in older patients. METHODS:Randomized trials that compared ARBs to control and reported clinical outcomes in patients with a mean age of 65 years or ol...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析,评审

    doi：10.1093/ajh/hpu209

    authors： Elgendy IY,Huo T,Chik V,Pepine CJ,Bavry AA

    更新日期：2015-05-01 00:00:00

  • Trends in Adolescents Obesity and the Association between BMI and Blood Pressure: A Cross-Sectional Study in 714,922 Healthy Teenagers.

    abstract：BACKGROUND:Seventeen percent of youth in the United States are obese. Obesity has been linked to higher prevalence of hypertension. Past studies were limited by their size and conflicting results. The aim of this study was to analyze trends in adolescents' obesity between 1998 and 2011 and to evaluate the relationship ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv007

    authors： Chorin E,Hassidim A,Hartal M,Havakuk O,Flint N,Ziv-Baran T,Arbel Y

    更新日期：2015-09-01 00:00:00

  • Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study.

    abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2007.47

    authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

    更新日期：2008-02-01 00:00:00

  • Social and economic factors as obstacles to blood pressure control.

    abstract：:Further improvement in blood pressure control at the population level will result from dealing with hard-to-solve problems, such as access to care, long-term management of a chronic disease, and societal influences on lifestyle. Additional knowledge and experimental data are needed, reinforced by clear public health c...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00082-x

    authors： Lang T

    更新日期：1998-07-01 00:00:00

  • Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta.

    abstract：BACKGROUND:Aging is a major risk factor for the development of arterial stiffness and vascular disease, and it is related to the upregulation of matrix metalloproteinase-2 (MMP-2) in the aorta of rats and nonhuman primates. This study aimed to determine whether MMP activity in the human vasculature changes with aging. ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.11.011

    authors： McNulty M,Spiers P,McGovern E,Feely J

    更新日期：2005-04-01 00:00:00

  • New approaches to screening for vascular and cardiac risk.

    abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02092-1

    authors： Cohn JN

    更新日期：2001-06-01 00:00:00

  • LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction.

    abstract：BACKGROUND:Myocardial infarction (MI) is commonly associated with cardiac hypertrophy, reduced Ca²(+) uptake into the sarcoplasmic reticulum (SR) and impaired myocardial relaxation. Treatment to prevent MI-associated complications is currently lacking. The purpose of the present study was to investigate the remodeling ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.157

    authors： Costa DG,da Silva JS,Kümmerle AE,Sudo RT,Landgraf SS,Caruso-Neves C,Fraga CA,de Lacerda Barreiro EJ,Zapata-Sudo G

    更新日期：2010-11-01 00:00:00

  • Rapid adjustment of antihypertensive drugs produces a durable improvement in blood pressure.

    abstract：:Antihypertensive drugs are often initiated and adjusted over a period of weeks to months. It is not clear whether the time and inconvenience of this approach is necessary. We studied whether or not drug adjustment over several days in the context of a physician-nurse team could produce a durable blood pressure benefit...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01273-5

    authors： Canzanello VJ,Jensen PL,Hunder I

    更新日期：2001-04-01 00:00:00

  • Associations of Reservoir-Excess Pressure Parameters Derived From Central and Peripheral Arteries With Kidney Function.

    abstract：BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa013

    authors： Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JE

    更新日期：2020-04-01 00:00:00

  • Relationship between autonomic function and progression of renal disease in diabetic proteinuria: clinical correlations and implications for blood pressure control.

    abstract：:The objective of this study was to test the relationship between neurologic and microvascular complications of type 1 diabetes mellitus. It was hypothesized that the mechanisms operative in autonomic dysfunction seen in diabetic patients with microangiopathy play a role in the rapidity of progression to renal failure....

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(97)00472-x

    authors： Weinrauch LA,Kennedy FP,Gleason RE,Keough J,D'Elia JA

    更新日期：1998-03-01 00:00:00

  • Glucocorticoid sensitivity of circulating monocytes in essential hypertension.

    abstract：BACKGROUND:Essential hypertension ranks among the strongest cardiovascular risk factors. Cytokine production by monocytes plays a key role in atherosclerosis development and acute coronary syndromes. We investigated whether stimulated monocyte cytokine release and its inhibition by glucocorticoids would differ between ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.01.010

    authors： Wirtz PH,von Känel R,Frey K,Ehlert U,Fischer JE

    更新日期：2004-06-01 00:00:00

  • Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats.

    abstract：:Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00042-9

    authors： Fedorova OV,Anderson DE,Bagrov AY

    更新日期：1998-07-01 00:00:00

  • Nonpeptide angiotensin II receptor antagonists.

    abstract：:Although the most direct way to interfere with the renin-angiotensin system (RAS) is at the level of the angiotensin II (AII) receptor, the currently available AII receptor antagonists are peptides still retaining significant agonistic properties with the obvious drawbacks of limited stability and lack of oral activit...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/3.8.599

    authors： Timmermans PB,Carini DJ,Chiu AT,Duncia JV,Price WA Jr,Wells GJ,Wong PC,Wexler RR,Johnson AL

    更新日期：1990-08-01 00:00:00

  • Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.

    abstract：BACKGROUND:This study was conducted to evaluate (i) the effect of nebivolol, a selective beta1-adrenergic receptor antagonist, on plasma concentration of asymmetric dimethylarginine (ADMA) and on flow-mediated dilation (FMD) in essential hypertensive patients; (ii) the effect of serum derived from the treated hypertens...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2008.260

    authors： Pasini AF,Garbin U,Stranieri C,Boccioletti V,Mozzini C,Manfro S,Pasini A,Cominacini M,Cominacini L

    更新日期：2008-11-01 00:00:00

  • Adjusting adiposity and body weight measurements for height alters the relationship with blood pressure in children.

    abstract：BACKGROUND:Adiposity measures are associated with increased pediatric blood pressure (BP). However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for h...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.82

    authors： Willig AL,Casazza K,Dulin-Keita A,Franklin FA,Amaya M,Fernandez JR

    更新日期：2010-08-01 00:00:00

  • Hemodynamic and endocrine responsiveness to mental arithmetic task and mirror drawing test in patients with essential hypertension.

    abstract：:To evaluate the reactivity to psychological stress in patients with essential hypertension we investigated hemodynamic and endocrinologic changes during a mental arithmetic task (MAT) and a mirror drawing test (MDT) in 10 hypertensive subjects. Hemodynamic changes were assessed continuously using an ambulatory radionu...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(96)00382-2

    authors： Yoshiuchi K,Nomura S,Ando K,Ohtake T,Shimosawa T,Kumano H,Kuboki T,Suematsu H,Fujita T

    更新日期：1997-03-01 00:00:00

  • Etiology and pathophysiology of stroke as a complex trait.

    abstract：:Stroke (brain attack) is currently the third leading cause of death in Western societies. Recent advances in molecular genetics have finally demonstrated what has long been suggested by the clinical observation, that is, stroke is not only the complication of major pathologic conditions such as atherosclerosis, hypert...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(00)01249-8

    authors： Rubattu S,Giliberti R,Volpe M

    更新日期：2000-10-01 00:00:00

  • Effects of hyperinsulinemia on the regulation of regional blood flow and blood pressure in anesthetized dogs: hemodynamic role of nitric oxide.

    abstract：:The purpose of this study was to investigate whether acute hyperinsulinemia induces selective hemodynamic effects in the mesenteric, renal, and iliac vascular beds, and to determine whether nitric oxide (NO) plays a role in the regulation of blood flow and mean arterial pressure (MAP) during acute hyperinsulinism. In ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00133-2

    authors： Villa E,García-Robles R,Romero JC

    更新日期：1998-10-01 00:00:00

  • Prenatal Exposure to LPS Alters The Intrarenal RAS in Offspring, Which Is Ameliorated by Adipose Tissue-Derived Mesenchymal Stem Cells.

    abstract：BACKGROUND:Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cell...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx117

    authors： Ding XF,Sun M,Guan FX,Guo LN,Zhang YY,Wan YD,Zhang XJ,Yu YW,Ma SS,Yao HM,Yao R,Zhang RF,Sun TW,Kan QC

    更新日期：2017-11-06 00:00:00

  • Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.

    abstract：BACKGROUND:A resequencing study of renal epithelial sodium channel (ENaC) genes was conducted to identify rare variants associated with blood pressure (BP) salt-sensitivity. METHODS:The Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study was conducted among 1,906 participants who underwent a 7-day low-sod...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1093/ajh/hpx169

    authors： Gu X,Gu D,He J,Rao DC,Hixson JE,Chen J,Li J,Huang J,Wu X,Rice TK,Shimmin LC,Kelly TN

    更新日期：2018-01-12 00:00:00

  • Clofibrate acutely reverses saline-induced endothelial dysfunction: role of calcium-activated potassium channels.

    abstract：BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.04.005

    authors： Sankaralingam S,Desai KM,Wilson TW

    更新日期：2006-11-01 00:00:00

  • Retinal arteriolar narrowing and left ventricular hypertrophy in African Americans. the Atherosclerosis Risk in Communities (ARIC) study.

    abstract：BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2007.57

    authors： Tikellis G,Arnett DK,Skelton TN,Taylor HW,Klein R,Couper DJ,Richey Sharrett A,Yin Wong T

    更新日期：2008-03-01 00:00:00

  • Sodium regulation in the affinity of renal alpha 2-adrenoceptors for epinephrine in Sabra salt-sensitive and salt-resistant rats.

    abstract：:Sodium ions markedly decreased in vitro renal alpha 2-adrenoceptor affinity for epinephrine in Sabra hypertensive (SBH) but not in normotensive (SBN) rats. Under these conditions, affinity of alpha 1-adrenoceptor for epinephrine was unchanged in SBH and SBN rats. If these data could be confirmed in vivo, the sodium io...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.3.267

    authors： Qing W,Dausse JP,Ben-Ishay D

    更新日期：1991-03-01 00:00:00

  • Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle.

    abstract：BACKGROUND:Insulin inhibits contraction and migration of primary confluent, cultured canine vascular smooth muscle cells (VSMCs) with inducible nitric oxide synthase (iNOS) by stimulating cyclic GMP (cGMP) production. The present study was performed to determine how insulin stimulates guanylate cyclase activity in thes...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02289-0

    authors： Kahn AM,Allen JC,Zhang S

    更新日期：2002-03-01 00:00:00