Sodium regulation in the affinity of renal alpha 2-adrenoceptors for epinephrine in Sabra salt-sensitive and salt-resistant rats.

Abstract:

:Sodium ions markedly decreased in vitro renal alpha 2-adrenoceptor affinity for epinephrine in Sabra hypertensive (SBH) but not in normotensive (SBN) rats. Under these conditions, affinity of alpha 1-adrenoceptor for epinephrine was unchanged in SBH and SBN rats. If these data could be confirmed in vivo, the sodium ion, by acting as an inhibitor, could modify the effect of agonists on renal alpha 2-adrenoceptors in SBH rats. Conversely, the absence of sodium regulation in SBN rats might represent a genetically mediated change responsible for the resistance to the development of salt-induced hypertension.

journal_name

Am J Hypertens

authors

Qing W,Dausse JP,Ben-Ishay D

doi

10.1093/ajh/4.3.267

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

267-70

issue

3 Pt 1

eissn

0895-7061

issn

1941-7225

journal_volume

4

pub_type

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