Quinapril prevents stroke both during and after the treatment period in stroke-prone spontaneously hypertensive rats.

abstract：:The aim of this study was to compare the efficacy (lowering diastolic blood pressure to 90 mm Hg or less) of urapidil, a postsynaptic alpha-blocker with central action with that of captopril in a randomized, double-blind, multicenter study. Two hundred ninety-five essential hypertensives (WHO I/II) (140 male, 155 fema...

journal_title：American journal of hypertension

authors： Rosenthal J,Schäfer N,Haerlin R,Wurst W,Solleder P

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...

journal_title：American journal of hypertension

authors： Tapia-Castillo A,Carvajal CA,Campino C,Vecchiola A,Allende F,Solari S,García L,Lavanderos S,Valdivia C,Fuentes C,Lagos CF,Martínez-Aguayo A,Baudrand R,Aglony M,García H,Fardella CE

更新日期：2014-03-01 00:00:00

abstract：:It has been suggested that atheroma formation is a chronic inflammatory response to lipid-derived inflammatory mediators accumulating at selected arterial sites. At large artery flow dividers and curvatures, secondary flow phenomena create zones of stagnation and recirculation that deprive endothelial cells of shear s...

journal_title：American journal of hypertension

authors： Henry PD,Chen CH

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. The present study was aimed to investigate hemodynamic factors that are...

journal_title：American journal of hypertension

authors： Hsu PF,Cheng HM,Sung SH,Chuang SY,Lakatta EG,Yin FC,Chou P,Chen CH

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Aim of this study was to evaluate the effect of the telmisartan-amlodipine combination at different doses on urinary albumin excretion rate (UAER) in hypertensive diabetic patients with microalbuminuria. METHODS:After a 2-week placebo period, 300 hypertensive patients with type 2 diabetes and microalbuminur...

journal_title：American journal of hypertension

authors： Fogari R,Derosa G,Zoppi A,Preti P,Lazzari P,Destro M,Fogari E,Rinaldi A,Mugellini A

更新日期：2007-04-01 00:00:00

abstract：:Our objective was to evaluate pretreatment predictors of longevity, particularly blood pressure, in a large cohort of hypertensive men. During 1974 to 1976, 10,367 male hypertensive veterans (47% black) were identified at screening and subsequently characterized in 32 special Veterans Administration (VA) hypertension ...

journal_title：American journal of hypertension

authors： Perry HM Jr,Miller JP,Baty JD,Carmody SE,Sambhi MP

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

journal_title：American journal of hypertension

authors： Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Ascending aortic fractional pulse pressure and fractional systolic pressure (FSP) were demonstrated to differentiate patients with and without coronary artery disease. However, no study so far has analyzed the relationship between FSP and fractional diastolic pressure (FDP) and the extent of coronary artery ...

journal_title：American journal of hypertension

authors： Jankowski P,Kawecka-Jaszcz K,Bryniarski L,Czarnecka D,Brzozowska-Kiszka M,Pośnik-Urbańska A,Kopeć G,Dragan J,Klecha A,Dudek D

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The ratio of urinary concentrations of tetrahydrocortisol plus allotetrahydrocortisol to tetrahydrocortisone [(THF + ATHF)/THE] reflects the activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11BHSD2), which converts cortisol to cortisone in the kidney and thereby protects the mineralocortico...

journal_title：American journal of hypertension

authors： Melander O,Frandsen E,Groop L,Hulthén UL

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. METHODS:We ...

journal_title：American journal of hypertension

authors： Doi Y,Iwashima Y,Yoshihara F,Kamide K,Takata H,Fujii T,Kubota Y,Nakamura S,Horio T,Kawano Y

更新日期：2012-12-01 00:00:00

abstract：:In order to determine the developmental pattern of atrial concentrations of atrial natriuretic factor (ANF) in the Dahl hypertension-prone rat, atrial ANF concentrations were measured in inbred hypertension-prone (S/JR) and hypertension-resistant (R/JR) Dahl rats at 5, 15, 25, and 51 days of age. In both strains, atri...

journal_title：American journal of hypertension

authors： Wilson TA,Dolan LM,McCaughran JA,Dobrozsi DJ,Juno CJ,Young CA

更新日期：1988-01-01 00:00:00

abstract：:The "totality" of hypertension clinical trial endpoint data has shown that the absolute benefit of pharmacological blood pressure (BP) lowering is directly related to the BP level and baseline cardiovascular risk, albeit with attenuation of the relative risk reduction per unit of BP lowering in patients with diabetes ...

journal_title：American journal of hypertension

authors： Flack JM,Nolasco C,Levy P

更新日期：2017-01-01 00:00:00

abstract：:Recently, we described a circulating hypertensive factor, present in the plasma of spontaneously hypertensive rats (SHR). This factor seems to be produced by the parathyroid gland but is not identical to parathyroid hormone (PTH). In view of these findings, we attempted to search for histological differences in parath...

journal_title：American journal of hypertension

authors： Kaneko T,Ohtani R,Lewanczuk RZ,Pang PK

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:There is evidence that diuretics and beta blockers impair glucose tolerance, whereas calcium channel blockers and angiotensin converting enzyme blockers lack this metabolic effect. We compared the effect of a combination therapy with a nondihydropyridine calcium channel blocker plus an angiotensin converting...

journal_title：American journal of hypertension

authors： Holzgreve H,Nakov R,Beck K,Janka HU

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) induces inflammation and vascular damage that might contribute to an increased risk of cardiovascular disease (CVD). However, the mechanisms linking OSA and CVD are not fully understood. Pentraxin3 may play a significant role in vascular inflammation and damage. Currently, there...

journal_title：American journal of hypertension

authors： Kasai T,Inoue K,Kumagai T,Kato M,Kawana F,Sagara M,Ishiwata S,Ohno M,Yamaguchi T,Momomura S,Narui K

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The genetic component related to blood pressure (BP) changes during pregnancy is still not elucidated. Thus, the aim of the study was to evaluate the association between leptin and leptin receptor polymorphisms and systolic (SBP) and diastolic BP (DBP) variation during pregnancy and the postpartum period. M...

journal_title：American journal of hypertension

authors： Farias DR,Franco-Sena AB,Rebelo F,Salles GF,Struchiner CJ,Martins MC,Kac G

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Determinants of exercise capacity have not been clearly defined in hypertensive patients. Doppler tissue imaging (DTI), a recently developed echocardiographic modality, is useful for evaluating left ventricular (LV) function regardless of loading conditions. The present study was performed to identify the de...

journal_title：American journal of hypertension

authors： Kim HK,Kim YJ,Cho YS,Sohn DW,Lee MM,Park YB,Choi YS

更新日期：2003-07-01 00:00:00

abstract：:The present study evaluates the growth promoting effect of insulin on the proliferative activity of cells from rat mesenteric arteries in culture in order to test the hypothesis that insulin may play a pathogenetic role in the hypertrophy of resistance vessels. The proliferative effect of insulin was studied in cultur...

journal_title：American journal of hypertension

authors： Cruzado M,Risler N,Castro C,Ortiz A,Rüttler ME

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...

journal_title：American journal of hypertension

authors： Hill LK,Sherwood A,Blumenthal JA,Hinderliter AL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Population-level sociologic studies have suggested that adverse societal conditions may affect fetal viability in a sex-specific manner and thereby modify the ratio of male vs. female babies. This concept suggests that there may exist certain physiologic features in a woman that relate to her likelihood of d...

journal_title：American journal of hypertension

authors： Retnakaran R,Wen SW,Tan H,Zhou S,Ye C,Shen M,Smith GN,Walker MC

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cell...

journal_title：American journal of hypertension

authors： Ding XF,Sun M,Guan FX,Guo LN,Zhang YY,Wan YD,Zhang XJ,Yu YW,Ma SS,Yao HM,Yao R,Zhang RF,Sun TW,Kan QC

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

journal_title：American journal of hypertension

authors： Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

更新日期：2012-05-01 00:00:00

abstract：:To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

journal_title：American journal of hypertension

authors： de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study. METHODS:A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli...

journal_title：American journal of hypertension

authors： Yang X,He J,Gu D,Hixson JE,Huang J,Rao DC,Shimmin LC,Chen J,Rice TK,Li J,Schwander K,Kelly TN

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:There is an association between maternal body mass index (BMI) and preeclampsia, but if BMI has an effect on preeclampsia of all severities is debated. If there is an association between maternal height and preeclampsia of all severities is unknown. METHODS:In this population-based cohort study including 50...

journal_title：American journal of hypertension

authors： Sohlberg S,Stephansson O,Cnattingius S,Wikström AK

更新日期：2012-01-01 00:00:00

abstract：:The results of 19 antihypertensive treatment trials spanning some 20 years of research showed that treatment had significant benefits for pressure-related complications of hypertension but generally did not prevent coronary artery disease morbidity or mortality. As possible reasons for this relative failure were explo...

journal_title：American journal of hypertension

authors： Rosenman RH

更新日期：1989-12-01 00:00:00

abstract：:Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

journal_title：American journal of hypertension

authors： Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...

journal_title：American journal of hypertension

authors： Cacciolati C,Hanon O,Alpérovitch A,Dufouil C,Tzourio C

更新日期：2011-06-01 00:00:00

abstract：:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and comp...

journal_title：American journal of hypertension

authors： Sarafidis PA,Lasaridis AN

更新日期：2006-06-01 00:00:00

abstract：:To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ...

journal_title：American journal of hypertension

authors： Resnick LM,Bardicef O,Altura BT,Alderman MH,Altura BM

更新日期：1997-12-01 00:00:00