Recent landmark clinical trials: how do they modify the therapeutic paradigm?

abstract：BACKGROUND:Hypertension and smoking independently contribute to the risk of stroke. Our objective was to investigate home blood pressure (HBP) levels, day-by-day BP variability, and smoking in the prediction of stroke in Japanese men. METHODS:In this study, 902 men (mean age, 58.6 years) without a past history of stro...

journal_title：American journal of hypertension

authors： Hashimoto T,Kikuya M,Ohkubo T,Satoh M,Metoki H,Inoue R,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Sato H,Imai Y

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS:This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,...

journal_title：American journal of hypertension

authors： Eguchi K,Hoshide S,Komori T,Nagasaka S,Kario K

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Hypertension presents high prevalence rates following kidney transplantation (Tx). The aims of the present study were to investigate the prevalence and possible risk factors for hypertension and blood pressure (BP) control over time after pediatric kidney Tx, as well as to assess possible effects of hyperten...

journal_title：American journal of hypertension

authors： Stabouli S,Printza N,Dotis J,Gkogka C,Kollios K,Kotsis V,Papachristou F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Functional status may be useful for identifying older adults who benefit from lower blood pressure. We examined whether functional status modifies the effect of antihypertensive treatment among older adults. METHODS:Post hoc analyses of the Systolic Hypertension in the Elderly Program (SHEP), a randomized t...

journal_title：American journal of hypertension

authors： Charlesworth CJ,Peralta CA,Odden MC

更新日期：2016-06-01 00:00:00

abstract：:Fenoldopam (Corlopam), a new dopaminergic agent in clinical development by SmithKline Beecham Pharmaceuticals, is a dopamine-1 (DA1) agonist at post-synaptic dopamine receptors. Preclinical and clinical studies have demonstrated that it is a potent renal vasodilator as well as a peripheral vasodilator. In both normal ...

journal_title：American journal of hypertension

authors： Holcslaw TL,Beck TR

更新日期：1990-06-01 00:00:00

abstract：:The relationship between erythrocyte cation transport systems and membrane and plasma lipids was examined in normal men and patients with insulin-dependent diabetes mellitus (IDDM). Different measurements of erythrocyte transport systems were obtained in patients with IDDM and in age- and weight-matched healthy men: N...

journal_title：American journal of hypertension

authors： Lijnen P,Fenyvesi A,Bex M,Bouillon R,Amery A

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors are the drugs of choice in renal hypertension. The efficacy and safety of ramipril in adults has been proved; however, data on effectiveness of ramipril in children are few. The aim of the present study was to investigate the effect of ramipril on blood pressure (BP) ...

journal_title：American journal of hypertension

authors： Seeman T,Dusek J,Vondrák K,Flögelová H,Geier P,Janda J

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs) increase arterial compliance and decrease left ventricular mass in hypertensive patients. This study examined whether combined therapy has greater arterial and cardiac effects than doubled doses of the individual drugs. METHO...

journal_title：American journal of hypertension

authors： Neutel JM,Smith DH,Weber MA

更新日期：2004-01-01 00:00:00

abstract：:The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to sur...

journal_title：American journal of hypertension

authors： Haass M,Fischer TA,Hänze J,Saggau W,Lang RE,Dietz R

更新日期：1990-03-01 00:00:00

abstract：:Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...

journal_title：American journal of hypertension

authors： Black HR

更新日期：1998-01-01 00:00:00

abstract：:Smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate in culture faster than those isolated from sex- and age-matched Wistar-Kyoto (WKY) animals. There was no difference in the kinetics of S6 kinase activation in the two cultures, but later metabolic events associated with proliferation were stimu...

journal_title：American journal of hypertension

authors： Scott-Burden T,Resink TJ,Hahn AW,Bühler FR

更新日期：1991-02-01 00:00:00

abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...

journal_title：American journal of hypertension

authors： Giner V,Fernández C,Esteban MJ,Galindo MJ,Forner MJ,Guix J,Redón J

更新日期：2002-05-01 00:00:00

abstract：:We studied the role of the sympathetic nervous system and the renin angiotensin system for pressure induced left ventricular hypertrophy (LVH) in 135 rats with experimental supravalvular aortic stenosis (AS). We induced this condition by a silver clip on the ascending aorta, when body weight (BW) was 90 to 100 g. Symp...

journal_title：American journal of hypertension

authors： Kromer EP,Elsner D,Riegger GA

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases (CVD) are responsible for more than 50% of the deaths in patients with end-stage renal disease (ESRD). Sleep apnea (SA) has been recognized as a risk factor for CVD. Previous studies have shown a higher prevalence of SA among patients on dialysis. METHODS:Forty-five nondiabetics pati...

journal_title：American journal of hypertension

authors： de Oliveira Rodrigues CJ,Marson O,Tufic S,Kohlmann O Jr,Guimarães SM,Togeiro P,Ribeiro AB,Tavares A

更新日期：2005-02-01 00:00:00

abstract：:Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...

journal_title：American journal of hypertension

authors： Mizuno Y,Jacob RF,Mason RP

更新日期：2008-10-01 00:00:00

abstract：:This study was designed to clarify the relationship between the antihypertensive effects of the calcium antagonist nilvadipine, and circadian changes in blood pressure. Based on measurements using an ambulatory blood pressure monitoring system (ABPM), 17 outpatients with untreated essential hypertension were divided i...

journal_title：American journal of hypertension

authors： Yoshikawa H,Ohta A,Kasamatsu K,Ueno C,Funai H,Kuse S,Satani O,Nakamura N,Fukuda K,Hano T,Ueno Y,Nishio I,Iseki Y

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Little is known about hypertension in the HIV-infected population. This study aimed to assess the prevalence of hypertension and related factors in HIV-infected patients. METHODS:In this prospective cross-sectional study, 710 HIV-infected patients (626 on combination antiretroviral therapy and 84 naive) man...

journal_title：American journal of hypertension

authors： Jericó C,Knobel H,Montero M,Sorli ML,Guelar A,Gimeno JL,Saballs P,López-Colomés JL,Pedro-Botet J

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The question of whether reduced sodium intake is effective as a health prophylaxis initiative is unsolved. The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids. METHODS:Studies randomizing persons to low-sodium an...

journal_title：American journal of hypertension

authors： Graudal NA,Hubeck-Graudal T,Jürgens G

更新日期：2012-01-01 00:00:00

abstract：:This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

journal_title：American journal of hypertension

authors： Ménard J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

journal_title：American journal of hypertension

authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

更新日期：2008-02-01 00:00:00

abstract：:Experimental research using in vitro and in vivo models of vascular injury have delineated several common mechanisms that characterize the arterial damage in diseases such as atherosclerosis and hypertension. Changes in endothelial permeability, smooth muscle cell proliferation, and accumulation of connective tissue m...

journal_title：American journal of hypertension

authors： Weinstein DB,Heider JG

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Hypertension is the leading global preventable risk factor for premature death. While hypertension prevalence has been declining in high-income countries, it has increased continuously in low- and middle-income countries. METHODS:We conducted a cross-sectional survey in 7,524 women and men aged 35-74 years ...

journal_title：American journal of hypertension

authors： Rubinstein AL,Irazola VE,Calandrelli M,Chen CS,Gutierrez L,Lanas F,Manfredi JA,Mores N,Poggio R,Ponzo J,Seron P,Bazzano LA,He J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal bloo...

journal_title：American journal of hypertension

authors： Kasahara A,Adachi H,Hirai Y,Enomoto M,Fukami A,Yoshikawa K,Esaki E,Yokoi K,Ogata K,Tsukagawa E,Obuchi A,Yoshimura A,Nakamura S,Imaizumi T

更新日期：2013-06-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...

journal_title：American journal of hypertension

authors： Schifter S,Krusell LR,Sehested J

更新日期：1991-07-01 00:00:00

abstract：:Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled, uncontrolled study was initiated in o...

journal_title：American journal of hypertension

authors： Shieh SM,Sheu WH,Shen DD,Fuh MM,Jeng CY,Jeng JR,Chen YD,Reaven GM

更新日期：1992-08-01 00:00:00

abstract：:To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...

journal_title：American journal of hypertension

authors： Lawrence DL,Shenker Y

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...

journal_title：American journal of hypertension

authors： Griffin FC,Gadegbeku CA,Sowers MR

更新日期：2011-03-01 00:00:00

abstract：:Twenty-four-hour ambulatory blood pressure measurements (ABPM) are likely to eliminate the stress of visits and observer bias in office blood pressure (BP) recordings, allow consideration of the circadian variability in BP, and correlate well with target organ damage. To define the prevalence of "white coat" hypertens...

journal_title：American journal of hypertension

authors： Khoury S,Yarows SA,O'Brien TK,Sowers JR

更新日期：1992-09-01 00:00:00

abstract：:The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

journal_title：American journal of hypertension

authors： Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

journal_title：American journal of hypertension

authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

更新日期：2008-11-01 00:00:00