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Ramipril in the treatment of hypertension and proteinuria in children with chronic kidney diseases.

Abstract：

BACKGROUND:Angiotensin-converting enzyme inhibitors are the drugs of choice in renal hypertension. The efficacy and safety of ramipril in adults has been proved; however, data on effectiveness of ramipril in children are few. The aim of the present study was to investigate the effect of ramipril on blood pressure (BP) and proteinuria in children with chronic kidney diseases. METHODS:A total of 31 children (median age 11.3 years, range 1.9-19.8 years) with various chronic nephropathies and hypertension or proteinuria were prospectively treated with ramipril for 6 months. Blood pressure was evaluated using ambulatory BP monitoring and hypertension was defined as mean BP equal to or greater than the 95th percentile for healthy children. Proteinuria was defined as protein excretion > or =100 mg/m(2)/24 h. The starting dose of ramipril was 1.5 mg/m(2)/24 h once daily. In 27 children it was given as monotherapy. RESULTS:The median decrease in ambulatory BP was 11 mm Hg for daytime systolic, 10 mm Hg for daytime and nighttime diastolic, and 8 mm Hg for nighttime systolic BP. Hypertension normalized in 55% of the children. Proteinuria decreased in 84% of the children with pathologic proteinuria; the median decrease was 51%. A positive correlation was found between initial proteinuria and change of proteinuria (r = 0.95, P <.001). Glomerular filtration rate and serum potassium level did not change significantly. One child developed a cough that was believed to be related to ramipril. CONCLUSIONS:Ramipril is an effective and safe drug in children with chronic kidney diseases associated with hypertension, proteinuria, or both.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Seeman T,Dusek J,Vondrák K,Flögelová H,Geier P,Janda J

doi

10.1016/j.amjhyper.2004.01.008

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

415-20

issue

5 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895706104000342

journal_volume

17

pub_type

杂志文章

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