Abstract：
BACKGROUND:Determinants of exercise capacity have not been clearly defined in hypertensive patients. Doppler tissue imaging (DTI), a recently developed echocardiographic modality, is useful for evaluating left ventricular (LV) function regardless of loading conditions. The present study was performed to identify the determinants of exercise capacity in hypertensive patients using DTI. METHODS:We studied 48 hypertensive patients (26 men; mean age, 57 +/- 9 years) with normal LV ejection fraction (>50%). Conventional echocardiographic indexes were measured before and after symptom-limited treadmill exercise. Also, longitudinal systolic (S(L)') and diastolic myocardial velocities (E(L)' and A(L)') and radial velocities (S(R)', E(R)', A(R)') were measured using DTI with the sample volume at the LV basal posterior wall. RESULTS:Mean exercise time was 525 +/- 135 sec. Mean LV ejection fraction was 61% +/- 6%. Mean LV mass index was 110.9 +/- 24.4 g/m(2). On univariate analysis, S(L)', E(L)', A(L)' and percentage increase of S(R)' velocity after exercise showed significant correlation with exercise time. However, only E(L)' and percentage increase of S(R)' remained significant after multivariate analysis. CONCLUSIONS:Left ventricular contractile reserve and relaxation property are important cardiac factors determining exercise capacity. Early diastolic longitudinal myocardial velocity might be useful for identifying hypertensive patients with poor exercise capacity.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Kim HK,Kim YJ,Cho YS,Sohn DW,Lee MM,Park YB,Choi YSdoi
10.1016/s0895-7061(03)00842-2subject
Has Abstractpub_date
2003-07-01 00:00:00pages
564-9issue
7eissn
0895-7061issn
1941-7225pii
S0895706103008422journal_volume
16pub_type
杂志文章abstract：:Managing hypertension is a complex undertaking, where even the definition of the disorder is subject to discussion. Recently, there has been controversy concerning the most appropriate measure to determine health risks associated with hypertension. In the past, diastolic blood pressure (DBP) was the prime measure for ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02131-8
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Carotid-femoral pulse-wave velocity (PWV) provides a comprehensive noninvasive indication of arterial stiffness, and is now established as a strong marker of cardiovascular disease (CVD). The correlation between peripheral blood pressure (BP) and PWV and their respective influences on mortality have been poo...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hps042
更新日期：2013-02-01 00:00:00
abstract：:Plasma renin activity and the relationship of renin activity and sodium excretion were analyzed in 50 untreated essential hypertensives classified according to their erythrocyte Na+ transport abnormalities. Renin activity was inappropriately high in 7 patients with increased activity of Na+,Li+ countertransport, inapp...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.5.412
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Calcium channel blockers such as amlodipine are effective antihypertensive agents. In this study we investigated the effects of amlodipine on vascular oxidative stress, expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1), and endothelial function in angiotensin (Ang) II-infused ra...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2003.09.007
更新日期：2004-02-01 00:00:00
abstract：:This study included the introduction of a new, qualitative, self-structured measure of quality of life (QOL) after meta-analysis had shown that prestructured quantitative measures yielded insignificant results. This study compared the pre- and post-treatment evaluations of 268 men with mild hypertension, aged 40 to 65...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/ajh/6.3.62s
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt277
更新日期：2014-03-01 00:00:00
abstract：:Alterations in Na, K ATPase pump activity as well as erythrocyte (RBC) intracellular sodium concentration (Nai) have been demonstrated in humans and rats with established hypertension. The contribution of hypertension itself to these changes is unclear. Accordingly, we investigated RBC ion transport and plasma ouabain...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.8.604
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:Hypertension and smoking independently contribute to the risk of stroke. Our objective was to investigate home blood pressure (HBP) levels, day-by-day BP variability, and smoking in the prediction of stroke in Japanese men. METHODS:In this study, 902 men (mean age, 58.6 years) without a past history of stro...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2012.62
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:The effect of age on the augmentation index (AI) differs between young adults and the elderly, and the AI reaches a plateau after the age of 60 years. We examined whether the effects of age and an elevation in blood pressure on the AI differ between young adults and the elderly, between subjects with and wit...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu082
更新日期：2014-12-01 00:00:00
abstract：:Severe short-term sodium restriction or extreme sodium loading may alter glucose tolerance and insulin resistance in patients with hypertension, but it is unclear whether variations in sodium intake within the clinically observed range affect glucose tolerance. To examine this issue, 21 patients with primary hypertens...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(01)01310-3
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.10.020
更新日期：2005-03-01 00:00:00
abstract：:Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.6.419
更新日期：1989-06-01 00:00:00
abstract：:Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urin...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ajh/3.12.903
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:Considering sex differences, salt sensitivity, and insulin resistance (IR), the effect of sodium restriction and increased potassium intake on blood pressure remains unclear in normotensive Asian individuals, compared to that in hypertensive patients. METHODS:To assess the influence of sodium and potassium ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy041
更新日期：2018-07-16 00:00:00
abstract：BACKGROUND:Various factors are implicated in the circadian pattern of cardiovascular vulnerability. The exact mechanisms involved in the peak incidence of cardiovascular events occurring during the early morning hours after awaking are not completely known. The purpose of our study was to investigate the circadian vari...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.09.020
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt051
更新日期：2013-08-01 00:00:00
abstract：:The role of dietary salt and calcium on changes in cellular cation metabolism has been evaluated in 11 salt-sensitive hypertensive black adults maintained on the following four metabolic diets for 56 days, 14 days on each diet in a repeated measures format: 356 mg Ca-1000 mg sodium (NA); 356 mg Ca-4000 mg Na; 934 Ca-1...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/1.4.386
更新日期：1988-10-01 00:00:00
abstract：:We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activatio...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with primary aldosteronism and, to a lesser degree, subjects with resistant hypertension. METHODS:In current analysis, we examined the antihypertensive benefit of adding low-dose spironolactone to mu...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(03)01032-x
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:High salt diet causes cardiac hypertrophy and fibrosis and increases cardiac aldosterone, while decreasing plasma aldosterone. The present study assessed, in Wistar rats, the effect of high salt diet on left and right ventricle (LV and RV, respectively) weight and fibrosis both with and without the aldostero...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(02)03268-5
更新日期：2003-04-01 00:00:00
abstract：:To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.5.341
更新日期：1989-05-01 00:00:00
abstract：:Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.01.014
更新日期：2005-07-01 00:00:00
abstract：:The objective of this study was to test the relationship between neurologic and microvascular complications of type 1 diabetes mellitus. It was hypothesized that the mechanisms operative in autonomic dysfunction seen in diabetic patients with microangiopathy play a role in the rapidity of progression to renal failure....
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00472-x
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. METHODS:Subjects (n = 792, mean age 62 years, 60% women) were asce...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.06.012
更新日期：2004-09-01 00:00:00
abstract：:The aim of this study was to assess whether an interaction exists between the renin-angiotensin system and the sympathetic nervous system at the level of the adrenal medulla during insulin-induced hypoglycemia in normal humans. Seventeen healthy volunteers were studied in a randomized, single-dose, double-blind, cross...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ajh/5.6.361
更新日期：1992-06-01 00:00:00
abstract：:To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/4.4.341
更新日期：1991-04-01 00:00:00
abstract：:Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...
journal_title：American journal of hypertension
pub_type： 历史文章,杂志文章
doi：10.1016/s0895-7061(99)00212-5
更新日期：2000-04-01 00:00:00
abstract：:After nephrectomy, the level of arterial pressure is determined by the permitted degree of fluid volume expansion. With kidneys present, the fundamental requirement for fluid volume homeostasis is met by maintaining the balance between sodium and water intake and output. When one-kidney, one-clip (1-K,1-C) hypertensio...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/4.10.534s
更新日期：1991-10-01 00:00:00
abstract：:The most common reason for an outpatient physician visit is for the diagnosis and treatment of hypertension. The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC) VII, which is increasingly evidence-based, advises the clinician to use studies of the mean response...
journal_title：American journal of hypertension
pub_type： 社论,评审
doi：10.1016/j.amjhyper.2003.12.007
更新日期：2004-04-01 00:00:00
abstract：:It has been suggested that atheroma formation is a chronic inflammatory response to lipid-derived inflammatory mediators accumulating at selected arterial sites. At large artery flow dividers and curvatures, secondary flow phenomena create zones of stagnation and recirculation that deprive endothelial cells of shear s...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/6.11.328s
更新日期：1993-11-01 00:00:00
