Abstract:
BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hypertension, high pulse rate, diabetes, and coronary heart disease were 63%, 16%, 5%, and 10% at baseline and were 64%, 20%, 6%, and 16% at 4 years after baseline. The mean 25(OH)D was 41±18 nmol/L. At baseline, systolic blood pressure (β = -0.048; P = 0.02), and pulse rate (β = -0.043; P = 0.04) were both associated with lower 25(OH)D levels but not coronary heart disease or diabetes prevalence. On remeasuring CVD risk 4 years after baseline, the only significant association with baseline 25(OH)D levels was high pulse rate (β = -0.077; P = 0.001). In addition, a higher 25(OH)D level at baseline was associated with a change in pulse rate (β = -0.055; P = 0.01). These trends for hypertension (baseline) and high pulse rate (baseline and 4 years after baseline) were also seen on adjusted categorical analysis (P trend < 0.05). CONCLUSIONS:Vitamin D deficiency at baseline was associated with hypertension in Finnish male smokers, but not after 4 years. These results are consistent with recent findings in other large cohort studies with measured blood pressure. Change in pulse rate over time continued to be significantly associated with lower 25(OH)D baseline levels; this new finding should be investigated further.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KEdoi
10.1093/ajh/hpt051subject
Has Abstractpub_date
2013-08-01 00:00:00pages
951-6issue
8eissn
0895-7061issn
1941-7225pii
hpt051journal_volume
26pub_type
杂志文章abstract::Renal artery stent placement has been shown to improve blood pressure (BP) and stabilize renal function in patients with atherosclerotic renovascular disease. However, limited data are available in patients > or = 75 years of age. We analyzed the prestent characteristics and clinical outcomes of patients aged > or = 7...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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abstract:BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHOD...
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abstract::The efficacy and safety of doxazosin (DOX) for the treatment of hypertension was investigated. A multicenter, double-blind, placebo-controlled, parallel design was employed. A 4-week placebo runin period was followed by a 9-week double-blind period during which patients were randomly assigned to placebo or 2, 4, or 8 ...
journal_title:American journal of hypertension
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更新日期:1988-04-01 00:00:00
abstract::The comparative efficacy of the calcium antagonists isradipine and nifedipine in reducing left ventricular peak systolic wall tension was assessed in 25 patients with essential hypertension (20 men, 5 women; mean age: 49 years). After 2 weeks of treatment with either isradipine (2.5 mg twice daily) or slow-release nif...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajh/6.3.92s
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...
journal_title:American journal of hypertension
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abstract:OBJECTIVE:The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS:This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Anthropometric measurements and indexes that assess excess of adiposity are associated with cardiovascular risk factors, and predict diabetes mellitus. METHODS:This cross-sectional study reported the performance of adiposity indexes to detect or turn diabetes unlikely in patients with hypertension. Patients...
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:
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journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:American journal of hypertension
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pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.08.013
更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00