Effect of short-term antihypertensive therapy on left ventricular wall tension. A double-blind comparison of isradipine and nifedipine.

Abstract:

:The comparative efficacy of the calcium antagonists isradipine and nifedipine in reducing left ventricular peak systolic wall tension was assessed in 25 patients with essential hypertension (20 men, 5 women; mean age: 49 years). After 2 weeks of treatment with either isradipine (2.5 mg twice daily) or slow-release nifedipine (20 mg twice daily), blood pressure was similarly reduced in both groups of patients whereas the thickness of the interventricular septum and left ventricular free wall did not change. Echocardiographic end-diastolic volume of the left ventricle showed no change whereas end-systolic volume significantly decreased with isradipine, but not with nifedipine retard. This led to a significant reduction in peak systolic wall tension in the isradipine group, but not in the nifedipine group. In conclusion, antihypertensive treatment with isradipine produces a reduction in peak systolic wall tension which is not seen with nifedipine, probably because of its negative inotropic effect.

journal_name

Am J Hypertens

authors

Griebenow R,Müller R,Steffen HM,Burger KJ,Welzel D

doi

10.1093/ajh/6.3.92s

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

92S-94S

issue

3 Pt 2

eissn

0895-7061

issn

1941-7225

pii

0895-7061(93)90243-F

journal_volume

6

pub_type

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