Prevention and Treatment of Hypertension Study (PATHS). Rationale and design.


:Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short duration, the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the Veterans Affairs (VA) Cooperative Studies Program have initiated a randomized, controlled, multicenter trial to determine whether blood pressure and left ventricular mass are lowered over 6 months of alcohol moderation in non-dependent moderate to heavy drinkers (three or more drinks per day average but not alcohol dependent) with above-average normal (80 to 89 mm Hg) and mildly hypertensive (90 to 99 mm Hg) levels of diastolic blood pressure, and whether a reduction in alcohol intake can be maintained for 2 years. Eligible veterans are randomized to either an alcohol reduction intervention or a control observation group at seven clinical sites. The projected sample size is 580 participants. Alcohol intake is assessed by self-report using a retrospective diary (Chronological Drinking Record) and by various biochemical markers, including apolipoproteins, HDL cholesterol (and subfractions), and carbohydrate deficient transferrin, analyzed at a central laboratory. The alcohol intervention technique is a cognitive-behavioral program, the intensive phase of which consists of six counseling sessions over 3 months. Echocardiograms are obtained at baseline and 6 months after randomization. This trial has important implications for both the prevention and treatment of hypertension.


Am J Hypertens


Cushman WC,Cutler JA,Bingham SF,Harford T,Hanna E,Dubbert P,Collins JF,Dufour M,Follman D,Allender PS




Has Abstract


1994-09-01 00:00:00




9 Pt 1










  • Ambulatory blood pressure and family history of hypertension in healthy men and women.

    abstract:BACKGROUND:Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP between individuals with two hypertensive parents, one hypertensive parent, and normotensive parents and whether this increase is apparent with both a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Goldstein IB,Shapiro D,Guthrie D

    更新日期:2006-05-01 00:00:00

  • Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study.

    abstract:BACKGROUND:Increased sodium intake has been positively associated with high blood pressure (BP) and hypertensive target organ damage, but associations with cardiac structure in nonhypertensive individuals have yielded inconsistent results. We tested the hypothesis that sodium intake is associated with left ventricular ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Dhingra R,Pencina MJ,Benjamin EJ,Levy D,Larson MG,Meigs JB,Rifai N,D'Agostino RB Sr,Vasan RS

    更新日期:2004-10-01 00:00:00

  • Hemodynamic responses to verapamil monotherapy in patients with renal disease.

    abstract::We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

    更新日期:1991-12-01 00:00:00

  • Post-transplant hypertension.

    abstract::Post-transplant hypertension remains an important risk factor for cardiovascular mortality and graft function. There are multiple mechanisms responsible for post-transplant hypertension. The details of these mechanisms are poorly understood. Steroids, acute and chronic rejection, recurrent renal disease, native kidney...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Laskow DA,Curtis JJ

    更新日期:1990-09-01 00:00:00

  • Endothelin: key mediator of hypertension in preeclampsia.

    abstract::Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficien...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: George EM,Granger JP

    更新日期:2011-09-01 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract:BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Simons AN,Moreland CJ,Kushalnagar P

    更新日期:2018-10-15 00:00:00

  • Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study.

    abstract:BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

    更新日期:2008-02-01 00:00:00

  • Hypertension and chronotherapy: shifting the treatment paradigm.

    abstract::The treatment of diseases has been based on the concept of homeostasis and has not incorporated an understanding of biologic rhythms and their underlying mechanisms. Biologic rhythms are implicated in cardiovascular events. Failure to recognize the circadian decline in blood pressure may result in iatrogenic chronopat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Prisant LM

    更新日期:2001-09-01 00:00:00

  • Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect.

    abstract::The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and comp...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Sarafidis PA,Lasaridis AN

    更新日期:2006-06-01 00:00:00

  • Barriers to hypertension care and control in young urban black men.

    abstract::Barriers to high blood pressure (HBP) care and control have been reported in the literature for > 30 years. Few reports on barriers, however, have focused on the young black man with HBP, the age/sex/race group with the highest rates of early severe and complicated HBP and the lowest rates of awareness, treatment, and...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hill MN,Bone LR,Kim MT,Miller DJ,Dennison CR,Levine DM

    更新日期:1999-10-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期:2008-06-01 00:00:00

  • High K diets markedly reduce atherosclerotic cholesterol ester deposition in aortas of rats with hypercholesterolemia and hypertension.

    abstract::High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tobian L,Jahner TM,Johnson MA

    更新日期:1990-02-01 00:00:00

  • A cross-national comparative study of blood pressure and hypertension between English and Dutch South-Asian- and African-origin populations: the role of national context.

    abstract:BACKGROUND:We compare patterns of blood pressure (BP) and prevalence of hypertension between white-Dutch and their South-Asian and African minority groups with their corresponding white-English and their South-Asian and African ethnic minority groups; and the contribution of physical activity, body sizes, and socioecon...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Agyemang C,Kunst A,Bhopal R,Zaninotto P,Unwin N,Nazroo J,Nicolaou M,Redekop WK,Stronks K

    更新日期:2010-06-01 00:00:00

  • Nocturnal Intermittent Hypoxia Is Associated With Left Ventricular Hypertrophy in Middle-Aged Men With Hypertension and Obstructive Sleep Apnea.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) and left ventricular (LV) hypertrophy are considered to be closely associated. However, the relationship has not yet been fully demonstrated and is hence still controversial. The purpose of this study was to assess in hypertensive male patients the relationship between OSA and c...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Yamaguchi T,Takata Y,Usui Y,Asanuma R,Nishihata Y,Kato K,Shiina K,Yamashina A

    更新日期:2016-03-01 00:00:00

  • Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.

    abstract::Stroke-prone spontaneously hypertensive rats (SHRSP), subjected to high NaCl, show severe hypertension, organ damage, and early death. Preventive treatment with angiotensin II type 1 (AT1) receptor antagonists is known to be effective. Previously, we found that angiotensin converting enzyme (ACE) inhibition could redu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Blezer EL,Nicolay K,Koomans HA,Joles JA

    更新日期:2001-01-01 00:00:00

  • Efficacy of low-dose spironolactone in subjects with resistant hypertension.

    abstract:BACKGROUND:Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with primary aldosteronism and, to a lesser degree, subjects with resistant hypertension. METHODS:In current analysis, we examined the antihypertensive benefit of adding low-dose spironolactone to mu...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Nishizaka MK,Zaman MA,Calhoun DA

    更新日期:2003-11-01 00:00:00

  • Antihypertensive action of beta-adrenoceptor blocking drugs. The role of intrarenal mechanisms.

    abstract::The different modes of antihypertensive action of beta-adrenoceptor blocking drugs are reviewed with a special emphasis on renal mechanisms of action. Beta-adrenoceptors occur in the kidney at the level of the juxtaglomerular and tubular cells. Direct intrarenal effects of beta-blockers include the decrease in renin r...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Struyker-Boudier HA,Smits JF

    更新日期:1989-11-01 00:00:00

  • Left ventricular mass in normotensive subjects. Importance of blood pressure response to activity.

    abstract::Recent works have shown the importance of blood pressure (BP) response to exercise or to daily activity as determinants of hypertensive cardiac hypertrophy. We have tested the relationship between BP and left ventricular (LV) mass in 23 normotensive young adults (mean age 25 +/- 5) with normotensive parents. Blood pre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gosse P,Desrumeau GC,Roudaut R,Broustet JP,Dallocchio M

    更新日期:1989-02-01 00:00:00

  • Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.

    abstract::The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

    更新日期:1994-07-01 00:00:00

  • Angiotensin II potentiates the arterial pressure response to volume loading in humans.

    abstract::Angiotensin II (AII) has many potential effects on blood pressure regulation in addition to direct vasoconstriction. This study tested the hypothesis that minimally pressor infusions of AII, which themselves exert minimal effects on blood pressure, might significantly perturb the pressure response to hypertonic volume...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goldsmith SR

    更新日期:1994-08-01 00:00:00

  • Association of renal resistive index with target organ damage in essential hypertension.

    abstract:BACKGROUND:The renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. METHODS:We ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Doi Y,Iwashima Y,Yoshihara F,Kamide K,Takata H,Fujii T,Kubota Y,Nakamura S,Horio T,Kawano Y

    更新日期:2012-12-01 00:00:00

  • Pressure modulates monocyte migration.

    abstract::Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increa...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Singhal PC,Sagar P,Gupta S,Arya M,Gupta M,Prasad A,Loona R,Sharma P,Mattana J

    更新日期:1997-11-01 00:00:00

  • Is endothelial function of the radial artery altered in human essential hypertension?

    abstract::There is controversy over whether endothelial function is impaired in human essential hypertension. All studies to date have used measurements of forearm blood flow by plethysmography to assess endothelium-dependent vasodilation and endothelial function. In contrast to these studies, which have focused on resistance v...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Schmieder RE,Weihprecht H,Schobel H,John S,Weidinger G,Gatzka C,Veelken R

    更新日期:1997-03-01 00:00:00

  • PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma.

    abstract:BACKGROUND:Parathyroid hormone (PTH) stimulates aldosterone secretion in human adrenocortex and is regulated by the renin-angiotensin-aldosterone system. We speculated that measurement of PTH may be a valuable aid in the diagnosis of aldosterone-producing adenoma (APA). METHODS:To test this hypothesis, we recruited 14...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Zhang LX,Gu WJ,Li YJ,Wang Y,Wang WB,Wang AP,Shen L,Zang L,Yang GQ,Lu ZH,Dou JT,Mu YM

    更新日期:2016-05-01 00:00:00

  • Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures With and Without N95 Respirators.

    abstract:BACKGROUND:The risk for cardiovascular events increases within hours of near-roadway exposures. We aimed to determine the traffic-related air pollution (TRAP) and biological mechanisms involved and if reducing particulate matter <2.5 µm (PM2.5) inhalation is protective. METHODS:Fifty healthy-adults underwent multiple ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Morishita M,Wang L,Speth K,Zhou N,Bard RL,Li F,Brook JR,Rajagopalan S,Brook RD

    更新日期:2019-10-16 00:00:00

  • Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial.

    abstract:BACKGROUND:Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled trial. METHODS:A total of 56...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Pickering TG,Shepherd AM,Puddey I,Glasser DB,Orazem J,Sherman N,Mancia G

    更新日期:2004-12-01 00:00:00

  • Impaired fibrinolysis and insulin resistance in patients with hypertension.

    abstract::Plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigens and activities were measured in 28 patients with hypertension and 12 normal controls. Steady state plasma glucose (SSPG) concentrations were also determined after an infusion of somatostatin, insulin and glucose. Pati...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Jeng JR,Sheu WH,Jeng CY,Huang SH,Shieh SM

    更新日期:1996-05-01 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract::Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Devereux RB

    更新日期:1989-08-01 00:00:00

  • Atrial natriuretic factor modulates the plasma levels of a Na+/K+ATPase inhibitor in volume expanded borderline hypertensives.

    abstract::To evaluate the existence of a relationship between atrial natriuretic factor (ANF) and plasma Na+/K+ATPase inhibitory activity in humans, we examined the hemodynamic and humoral response to volume expansion in 41 borderline hypertensive patients (BHT) with either normal (n = 33) or low plasma renin activity (n = 8). ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Boschi S,Costa FV,Ambrosioni E

    更新日期:1991-07-01 00:00:00

  • Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.

    abstract::To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

    更新日期:1992-05-01 00:00:00