Prevention and Treatment of Hypertension Study (PATHS). Rationale and design.

abstract：BACKGROUND:Structural and functional changes involved in cardiac injury induced by diabetes mellitus, pressure-overload, or both conditions were evaluated. METHODS:Pressure-overload was established by suprarenal aortic banding in rats. Six weeks later, diabetes was induced by streptozotocin (STZ, 65 mg/kg, intraperito...

journal_title：American journal of hypertension

authors： Falcão-Pires I,Gonçalves N,Moura C,Lamego I,Eloy C,Lopes JM,Begieneman MP,Niessen HW,Areias JC,Leite-Moreira AF

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...

journal_title：American journal of hypertension

authors： Hill LK,Sherwood A,Blumenthal JA,Hinderliter AL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...

journal_title：American journal of hypertension

authors： Triantafyllidi H,Arvaniti C,Lekakis J,Ikonomidis I,Siafakas N,Tzortzis S,Trivilou P,Zerva L,Stamboulis E,Kremastinos DT

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Hypertension presents high prevalence rates following kidney transplantation (Tx). The aims of the present study were to investigate the prevalence and possible risk factors for hypertension and blood pressure (BP) control over time after pediatric kidney Tx, as well as to assess possible effects of hyperten...

journal_title：American journal of hypertension

authors： Stabouli S,Printza N,Dotis J,Gkogka C,Kollios K,Kotsis V,Papachristou F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...

journal_title：American journal of hypertension

authors： Bundy JD,Jaeger BC,Huffman MD,Knox SS,Thomas SJ,Shimbo D,Booth Iii JN,Lewis CE,Edwards LJ,Schwartz JE,Muntner P

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:During the development of hypertension, glucose replaces triacylglycerols (TG) as the main energy source for the myocardium. However, there are no available studies investigating the TG molecular species composition of the myocardium in the spontaneously hypertensive rat (SHR). The objective of this study wa...

journal_title：American journal of hypertension

authors： Perona JS,Ruiz-Gutierrez V

更新日期：2005-01-01 00:00:00

abstract：:High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...

journal_title：American journal of hypertension

authors： Tobian L,Jahner TM,Johnson MA

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. The present study was conducted to clarify whether the IR is more closely related to the macrovasculature...

journal_title：American journal of hypertension

authors： Yoshida M,Tomiyama H,Yamada J,Matsumoto C,Odaira M,Shiina K,Yamashina A

更新日期：2010-05-01 00:00:00

abstract：:The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...

journal_title：American journal of hypertension

authors： Chang E,Kunes J,Hamet P,Tremblay J

更新日期：1990-08-01 00:00:00

abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

journal_title：American journal of hypertension

authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

更新日期：1989-12-01 00:00:00

abstract：:The role of an endogenous sodium pump inhibitor in the pathogenesis of hypertension has been reported in several papers. Unfortunately, because of the unknown structure and lack of biochemical characterization, some discrepancies have arisen. In this study we report a method to obtain extracts from human plasma that a...

journal_title：American journal of hypertension

authors： Boschi S,Munarini A,Borghi C,Strocchi E,Costa FV,Mussi A,Ettore A

更新日期：1988-07-01 00:00:00

abstract：:Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium. Moreover, in the absence of vascular endothelium, bradykinin also inhibits n...

journal_title：American journal of hypertension

authors： Greenberg SS,Peevy K,Tanaka TP

更新日期：1991-05-01 00:00:00

abstract：:Vasodilation is impaired in various conditions, such as hypercholesterolemia and tobacco use. We evaluated brachial artery flow-mediated vasodilation (FMD) after blood pressure (BP) cuff occlusion using high-resolution B-mode ultrasound in 20 alcoholics, without any coexisting conditions such as smoking, hypertension,...

journal_title：American journal of hypertension

authors： Maiorano G,Bartolomucci F,Contursi V,Minenna FS,Di Mise R,Palasciano A,Allegrini B,Amoruso M,Kozàkovà M

更新日期：1999-02-01 00:00:00

abstract：:Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adre...

journal_title：American journal of hypertension

authors： Malee MP,Wu KY

更新日期：1999-05-01 00:00:00

abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...

journal_title：American journal of hypertension

authors： Wimalawansa SJ

更新日期：1993-12-01 00:00:00

abstract：:National standards govern the manufacture and marketing of medical devices in the United States, including those for indirect blood pressure measurement in man. There are no comparable standards for devices for recording in laboratory animals. Noninvasive tail cuff blood pressure (BP) recording in the rat is widely ac...

journal_title：American journal of hypertension

authors： Jamieson MJ,Gonzales GM,Jackson TI,Koerth SM,Romano WF,Tan DX,Castillon F 3rd,Skinner MH,Grossmann M,Shepherd AM

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...

journal_title：American journal of hypertension

authors： Volcik KA,Ballantyne CM,Braun MC,Coresh J,Mosley TH,Boerwinkle E

更新日期：2008-05-01 00:00:00

abstract：:The aim of this study was to assess the macrostructure of the kidney and the grade of heterogeneity in renal cortical circulation in the early stages of essential hypertension. The subjects consisted of 84 patients (<50 years old) who underwent dynamic computed tomography (CT) because of various abdominal diseases and...

journal_title：American journal of hypertension

authors： Kojima S,Shida M,Tanaka K,Takano H,Yokoyama H,Kuramochi M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Dyslipidemia is one the most well-established risk factors for cardiovascular disease development. Moreover, hypercholesterolemia and plasma cholesterol level in the high to normal range are established triggers for impairment in endothelial function. Evidence indicates that endothelial function is closely l...

journal_title：American journal of hypertension

authors： Lambert E,Straznicky N,Sari CI,Eikelis N,Hering D,Head G,Dixon J,Esler M,Schlaich M,Lambert G

更新日期：2013-02-01 00:00:00

abstract：:The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

journal_title：American journal of hypertension

authors： Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

更新日期：2001-11-01 00:00:00

abstract：:Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT). The two studies involved ten patients with unilateral RVH, eight with...

journal_title：American journal of hypertension

authors： Imanishi M,Ohta M,Kawamura M,Akabane S,Matsushima Y,Kuramochi M,Kojima S,Kimura K,Takamiya M,Ito K

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Previous reports focused on the significant acute effects immediately after an earthquake on an increase in blood pressure (BP) assessed by ambulatory BP monitoring. However, there have been no data on the impact of environmental triggers on the long-term response to earthquake. METHODS:We analyzed the ambu...

journal_title：American journal of hypertension

authors： Nishizawa M,Hoshide S,Okawara Y,Shimpo M,Matsuo T,Kario K

更新日期：2015-12-01 00:00:00

abstract：:The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...

journal_title：American journal of hypertension

authors： O'Hagan KP,Thomas GD,Zambraski EJ

更新日期：1990-01-01 00:00:00

abstract：:Great pathophysiological significance has recently been placed on the association of metabolic abnormalities, such as hyperinsulinemia, insulin resistance, obesity, and frank diabetes mellitus, with essential hypertension and coronary artery disease, and the clinical coincidence of these features has been termed "synd...

journal_title：American journal of hypertension

authors： Resnick LM

更新日期：1993-04-01 00:00:00

abstract：:Renal artery stent placement has been shown to improve blood pressure (BP) and stabilize renal function in patients with atherosclerotic renovascular disease. However, limited data are available in patients > or = 75 years of age. We analyzed the prestent characteristics and clinical outcomes of patients aged > or = 7...

journal_title：American journal of hypertension

authors： Bloch MJ,Trost DA,Whitmer J,Pickering TG,Sos TA,August P

更新日期：2001-10-01 00:00:00

abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

journal_title：American journal of hypertension

authors： Epstein M

更新日期：2002-07-01 00:00:00

abstract：:We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the develop...

journal_title：American journal of hypertension

authors： Antic V,Kiener-Belforti F,Tempini A,Van Vliet BN,Montani JP

更新日期：2000-05-01 00:00:00

abstract：:Recently, we described a circulating hypertensive factor, present in the plasma of spontaneously hypertensive rats (SHR). This factor seems to be produced by the parathyroid gland but is not identical to parathyroid hormone (PTH). In view of these findings, we attempted to search for histological differences in parath...

journal_title：American journal of hypertension

authors： Kaneko T,Ohtani R,Lewanczuk RZ,Pang PK

更新日期：1989-07-01 00:00:00

abstract：:The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...

journal_title：American journal of hypertension

authors： Cacciafesta M,Ferri C,Carlomagno A,De Angelis C,Scuteri A,Guidoni L,Luciani AM,Rosi A,Viti V,Santucci A

更新日期：1994-02-01 00:00:00

abstract：:This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

journal_title：American journal of hypertension

authors： Ménard J

更新日期：1994-10-01 00:00:00