Abstract：
:Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short duration, the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the Veterans Affairs (VA) Cooperative Studies Program have initiated a randomized, controlled, multicenter trial to determine whether blood pressure and left ventricular mass are lowered over 6 months of alcohol moderation in non-dependent moderate to heavy drinkers (three or more drinks per day average but not alcohol dependent) with above-average normal (80 to 89 mm Hg) and mildly hypertensive (90 to 99 mm Hg) levels of diastolic blood pressure, and whether a reduction in alcohol intake can be maintained for 2 years. Eligible veterans are randomized to either an alcohol reduction intervention or a control observation group at seven clinical sites. The projected sample size is 580 participants. Alcohol intake is assessed by self-report using a retrospective diary (Chronological Drinking Record) and by various biochemical markers, including apolipoproteins, HDL cholesterol (and subfractions), and carbohydrate deficient transferrin, analyzed at a central laboratory. The alcohol intervention technique is a cognitive-behavioral program, the intensive phase of which consists of six counseling sessions over 3 months. Echocardiograms are obtained at baseline and 6 months after randomization. This trial has important implications for both the prevention and treatment of hypertension.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Cushman WC,Cutler JA,Bingham SF,Harford T,Hanna E,Dubbert P,Collins JF,Dufour M,Follman D,Allender PSdoi
10.1093/ajh/7.9.814subject
Has Abstractpub_date
1994-09-01 00:00:00pages
814-23issue
9 Pt 1eissn
0895-7061issn
1941-7225pii
0895-7061(94)90034-5journal_volume
7pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association betwee...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpz011
更新日期：2019-05-09 00:00:00
abstract：:Previous assessment of beta-adrenoceptor function has shown alterations in essential hypertension (EH). In the present study, we compared lymphocyte beta-adrenoceptor density (Bmax) and adenylate cyclase (AC) activity stimulated by l-isoproterenol, Gpp(NH)p, Gpp(NH)p + l-isoproterenol, and forskolin in 46 patients wit...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/5.6.266
更新日期：1992-06-01 00:00:00
abstract：:The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/6.11.951
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:It is not known whether strict control of blood pressure (BP) in mild post-transplant hypertension gives any benefit. Our primary objective was to test the antihypertensive effects of lisinopril added to standard therapy on ambulatory BP (ABP) of post-transplant patients. The secondary objective was to monit...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(02)02992-8
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Pre-eclampsia (PE) is characterized by hypertension and proteinuria, and complicates from 3%-10% of all pregnancies. The hemodynamic pathophysiology of the heart and systemic arteries in pre-eclamptic patients has not been well described. We therefore performed a comprehensive comparison of the systemic arte...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hps067
更新日期：2013-04-01 00:00:00
abstract：:Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/4.11s.608s
更新日期：1991-11-01 00:00:00
abstract：:The association between obesity and hypertension is well recognized. However, the exact mechanisms whereby obesity causes hypertension are complex and multifactorial. The current article summarizes some of the known mechanisms responsible for obesity hypertension. ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02299-3
更新日期：2002-02-01 00:00:00
abstract：:In order to further characterize previously described racial differences in intracellular Ca2+ homeostasis, the activity of sarcoplasmic-endoplasmic reticulum Ca2+-ATPase was measured in cultured skin fibroblasts from normotensive African-Americans and whites. Cells originated from apparently healthy, normotensive Afr...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(96)00415-3
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Carvedilol is known to be an adrenoreceptor blocker and free radical scavenger, used in hypertension and cardiac failure. However, its therapeutic actions cannot be fully explained by these mechanisms. In these studies, we tested the hypothesis that carvedilol action is associated with the synthesis/release ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.11.011
更新日期：2006-04-01 00:00:00
abstract：:To study the circulating humoral factor modifying transmembrane sodium transport, plasma was obtained from 12 patients with essential hypertension (EH) fed a high sodium diet (NaCl 15 to 17 g/d) for seven days and thereafter a low sodium diet (NaCl 2 to 3 g/d) for seven days. Ouabain-sensitive 86Rb+ influx into the re...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.7.560
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.04.023
更新日期：2005-10-01 00:00:00
abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(02)02948-5
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Insulin inhibits contraction and migration of primary confluent, cultured canine vascular smooth muscle cells (VSMCs) with inducible nitric oxide synthase (iNOS) by stimulating cyclic GMP (cGMP) production. The present study was performed to determine how insulin stimulates guanylate cyclase activity in thes...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02289-0
更新日期：2002-03-01 00:00:00
abstract：:The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(00)01186-9
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivit...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2008.215
更新日期：2008-08-01 00:00:00
abstract：:Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00239-3
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Aging is a major risk factor for the development of arterial stiffness and vascular disease, and it is related to the upregulation of matrix metalloproteinase-2 (MMP-2) in the aorta of rats and nonhuman primates. This study aimed to determine whether MMP activity in the human vasculature changes with aging. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.11.011
更新日期：2005-04-01 00:00:00
abstract：AIMS:Several studies have indicated that low physical activity is associated with increased risk of cardiovascular disease (CVD) and all-cause mortality among patients with diabetes. The association between physical activity and subclinical cardiovascular changes preceding clinical events remains to be elucidated. We i...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpv197
更新日期：2016-07-01 00:00:00
abstract：:Primary investigators of randomized drug trials in hypertension were invited to rate quality of such trials. The intention of the survey was to ask if antihypertensive drug therapy reduces incidence of coronary heart disease (CHD) in hypertensive patients. Response was obtained for 7 of the 11 invited investigators, c...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1093/ajh/7.8.703
更新日期：1994-08-01 00:00:00
abstract：:The benzothiazepine calcium channel antagonist diltiazem is a short-acting drug. To achieve effective 24-h blood pressure control with once-daily dosing, it relies on various extended drug-delivery systems that have grown in importance as a result of the recent reports relating the use of short-acting calcium channel ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(99)00097-7
更新日期：1999-10-01 00:00:00
abstract：:The purpose of this study was to examine the variability of 24-hour urinary and serum creatinine levels and creatinine clearance in normal subjects and to develop nomograms for assessing the adequacy of 24-hour urine collections. The data were from a longitudinal research program examining biochemical, hormonal, and h...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/1.2.124
更新日期：1988-04-01 00:00:00
abstract：:The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.1.62
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:Central blood pressure (BP) can be used to define hypertension. A central BP approach may be more sensitive than a conventional brachial BP approach in detecting hypertension. We aimed to compare the 2 approaches in estimating the prevalence hypertension in a nationally representative population. METHODS:A ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx178
更新日期：2018-02-09 00:00:00
abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw080
更新日期：2016-12-01 00:00:00
abstract：:Plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigens and activities were measured in 28 patients with hypertension and 12 normal controls. Steady state plasma glucose (SSPG) concentrations were also determined after an infusion of somatostatin, insulin and glucose. Pati...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/0895-7061(95)00442-4
更新日期：1996-05-01 00:00:00
abstract：:Decreased urinary kallikrein excretion has been shown to be related to hypertension. Kallikrein levels also have been shown to be determined primarily by genes, with 51% of the total variance being due to a single gene. However, there exists strong spouse-spouse correlation, indicating that common environment plays a ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/6.12.996
更新日期：1993-12-01 00:00:00
abstract：:The objective of this study was to evaluate whether the major histocompatibility complex of the rat can be related to blood pressure (BP) level and BP response to stress. Blood pressure was determined under light ether anesthesia or during moderate restraint stress in normotensive Lewis rats, in rat strains congenic w...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(96)00023-4
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:On the basis of evidence of plasma leptin (LE) effects on cardiovascular system, we assessed possible association of LE and Doppler-derived left ventricular (LV) diastolic function in arterial hypertension. METHODS:Doppler echocardiography, blood sample for fasting plasma LE levels, and euglycemic hyperinsu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02137-9
更新日期：2001-10-01 00:00:00
abstract：:A prospective randomized, double-blind, double-dummy study investigated the effects of two angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion in nondiabetic patients with mild to moderate essential hypertension. At the end of a 4-week placebo run-in period, 36 patients were randomly allocated ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/ajh/7.1.46
更新日期：1994-01-01 00:00:00
