Oil and water? Economic advantage and biomedical progress do not mix well in a government guidelines committee.


:This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatment guidelines based on economic motives will result in poorer patient care and less valuable medical research.


Am J Hypertens


Ménard J




Has Abstract


1994-10-01 00:00:00




10 Pt 1










  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract:BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期:2009-09-01 00:00:00

  • Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives.

    abstract:BACKGROUND:The polymorphism of several candidate genes has been studied in relation to essential hypertension and cardiovascular complications. Target organ damage in essential hypertension is a complex disorder influenced by multiple genetic and environmental factors. The possible contribution of endothelin gene varia...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lajemi M,Gautier S,Poirier O,Baguet JP,Mimran A,Gosse P,Hanon O,Labat C,Cambien F,Benetos A

    更新日期:2001-08-01 00:00:00

  • Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats.

    abstract::To determine if a remodeling of the collagen matrix would occur in the absence of hypertrophy and cell necrosis and if such a remodeling could alter active and passive stiffness of the intact myocardium, five rats with genetic hypertension (SHR) were treated (SHRT) with hydralazine for 32 weeks, beginning at four week...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Narayan S,Janicki JS,Shroff SG,Pick R,Weber KT

    更新日期:1989-09-01 00:00:00

  • Reversible posterior leukoencephalopathy secondary to indinavir-induced hypertensive crisis: a case report.

    abstract::Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Giner V,Fernández C,Esteban MJ,Galindo MJ,Forner MJ,Guix J,Redón J

    更新日期:2002-05-01 00:00:00

  • Nonpeptide angiotensin II receptor antagonists.

    abstract::Although the most direct way to interfere with the renin-angiotensin system (RAS) is at the level of the angiotensin II (AII) receptor, the currently available AII receptor antagonists are peptides still retaining significant agonistic properties with the obvious drawbacks of limited stability and lack of oral activit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Timmermans PB,Carini DJ,Chiu AT,Duncia JV,Price WA Jr,Wells GJ,Wong PC,Wexler RR,Johnson AL

    更新日期:1990-08-01 00:00:00

  • Effect of dietary sodium intake on intracellular calcium in lymphocytes of salt-sensitive hypertensive patients.

    abstract::High dietary Na+ raises mean arterial pressure (MAP) by more than 10% in salt-sensitive (SS) patients with essential hypertension. To test whether the rise in MAP in these patients is caused by a Na(+)-linked increase in [Ca2+]i in vascular smooth muscle cells, we measured [Ca2+]i in the lymphocytes of 14 patients wit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Alexiewicz JM,Gaciong Z,Parise M,Karubian F,Massry SG,Campese VM

    更新日期:1992-08-01 00:00:00

  • Childhood predictors of high blood pressure.

    abstract::Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mahoney LT,Clarke WR,Burns TL,Lauer RM

    更新日期:1991-11-01 00:00:00

  • Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans.

    abstract::Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gainer JV,Brown NJ,Bachvarova M,Bastien L,Maltais I,Marceau F,Bachvarov DR

    更新日期:2000-12-01 00:00:00

  • Albumin excretion rate and metabolic modifications in patients with essential hypertension. Effects of two angiotensin converting enzyme inhibitors.

    abstract::A prospective randomized, double-blind, double-dummy study investigated the effects of two angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion in nondiabetic patients with mild to moderate essential hypertension. At the end of a 4-week placebo run-in period, 36 patients were randomly allocated ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Puig JG,Mateos FA,Ramos TH,Lavilla MP,Capitán MC,Gil A

    更新日期:1994-01-01 00:00:00

  • Characterization of enhanced 45Ca2+ efflux in cultured vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract::In this study we have compared Ca2+ efflux in cultured aortic smooth muscle cells derived from male, 10-week-old spontaneously hypertensive and Wistar-Kyoto rats. The role of Ca(2+)-dependent protein kinase C and Ca2+ uptake in the regulation of the Ca2+ pump and Na(+)-Ca2+ exchange mediated Ca2+ efflux were investiga...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chen S,Monteith GR,Roufogalis BD

    更新日期:1995-10-01 00:00:00

  • Effects of aging on the insulin actions for the glucose metabolism and renal function in normotensives and essential hypertensives.

    abstract::It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

    更新日期:1998-09-01 00:00:00

  • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.

    abstract::Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P <.03) in hypertensive women than in normotensive women, although body mass index did not ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: El-Gharbawy AH,Kotchen JM,Grim CE,Kaldunski M,Hoffmann RG,Pausova Z,Hamet P,Kotchen TA

    更新日期:2002-11-01 00:00:00

  • The Case for Low Blood Pressure Targets.

    abstract::The "totality" of hypertension clinical trial endpoint data has shown that the absolute benefit of pharmacological blood pressure (BP) lowering is directly related to the BP level and baseline cardiovascular risk, albeit with attenuation of the relative risk reduction per unit of BP lowering in patients with diabetes ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Flack JM,Nolasco C,Levy P

    更新日期:2017-01-01 00:00:00

  • Platelet and erythrocyte membrane microviscosity in Lyon hypertensive rats.

    abstract::The altered membrane microviscosity demonstrated in various cells of spontaneously hypertensive rats (SHR) and essential hypertensive (EH) patients has been proposed to play an important role in the pathogenesis of genetic forms of hypertension. The aim of this study was to evaluate possible changes of membrane microv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Le Quan Sang KH,Kunes J,Zicha J,Vincent M,Sassard J,Devynck MA

    更新日期:1994-03-01 00:00:00

  • Impaired diurnal blood pressure variation and all-cause mortality.

    abstract:BACKGROUND:Most healthy people exhibit a decrease in systolic blood pressure (SBP) at night. A drop of <10% from mean daytime values, "non-dipping," is associated with kidney disease and cardiovascular events. We hypothesized that non-dipping would predict all-cause mortality. METHODS:Consecutive patients referred for...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Brotman DJ,Davidson MB,Boumitri M,Vidt DG

    更新日期:2008-01-01 00:00:00

  • Echocardiographic comparison of left ventricular structure and function in hypertensive patients with primary aldosteronism and essential hypertension.

    abstract:BACKGROUND:In experimental renovascular hypertension, aldosterone has been implicated in myocardial remodeling and fibrosis, but it is uncertain whether excess aldosterone effects left ventricular structure and function in hypertensive patients. METHODS:Hypertensive patients from the Cardiovascular Center of the New Y...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Goldkorn R,Yurenev A,Blumenfeld J,Fishman D,Devereux RB

    更新日期:2002-04-01 00:00:00

  • Magnetic resonance imaging compared to echocardiography to assess left ventricular mass in the hypertensive patient.

    abstract::Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient. Magnetic resonance imaging (MRI) may be a more precise and reliable method to quantify the mass of the left ventricule. This study reports the accuracy,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Bottini PB,Carr AA,Prisant LM,Flickinger FW,Allison JD,Gottdiener JS

    更新日期:1995-03-01 00:00:00

  • Endogenous marinobufagenin-like immunoreactive substance. A possible endogenous Na, K-ATPase inhibitor with vasoconstrictor activity.

    abstract::Vasoconstrictor and Na/K pump inhibitory properties of a bufodienolide Na/K-ATPase inhibitor, marinobufagenin, were studied in isolated rings of 2 to 3 order branches of human pulmonary arteries respectively. Marinobufagenin displayed concentration-dependent vasoconstrictor activity (0.01 to 10 mmol/L). In sarcolemma ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Bagrov AY,Dmitrieva RI,Fedorova OV,Kazakov GP,Roukoyatkina NI,Shpen VM

    更新日期:1996-10-01 00:00:00

  • Cognitive impairment is related to increased arterial stiffness and microvascular damage in patients with never-treated essential hypertension.

    abstract:BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Triantafyllidi H,Arvaniti C,Lekakis J,Ikonomidis I,Siafakas N,Tzortzis S,Trivilou P,Zerva L,Stamboulis E,Kremastinos DT

    更新日期:2009-05-01 00:00:00

  • Autonomic imbalance, hypertension, and cardiovascular risk.

    abstract::Essential hypertension conveys an increased risk of cardiovascular morbidity and mortality. The common finding of an autonomic imbalance in these patients contributes not only to the etiology of hypertension itself, but also to the cardiac risk and resulting adverse sequelae. A high sympathetic tone in particular is r...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Brook RD,Julius S

    更新日期:2000-06-01 00:00:00

  • A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/Lo

    abstract::The purpose of this double-blind, forced titration study was to compare the antihypertensive effect duration of candesartan cilexetil, which has a longlasting binding to the human AT1-receptor, to that of losartan on ambulatory BP (ABP) not only during the 24-h dosing interval but also during the day of a missed dose ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lacourcière Y,Asmar R

    更新日期:1999-12-01 00:00:00

  • Environmental determinants of urinary kallikrein excretion.

    abstract::Decreased urinary kallikrein excretion has been shown to be related to hypertension. Kallikrein levels also have been shown to be determined primarily by genes, with 51% of the total variance being due to a single gene. However, there exists strong spouse-spouse correlation, indicating that common environment plays a ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hunt SC,Wu LL,Slattery ML,Meikle AW,Williams RR

    更新日期:1993-03-01 00:00:00

  • Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension.

    abstract:BACKGROUND:Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension, but longitudinal studies are missing. METHODS:We performed an echocardiographic follow-up study in young initially normotensive male offspring of hypertensive (OHyp) (n = 25) and normotensive (ONorm) ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Aeschbacher BC,Hutter D,Fuhrer J,Weidmann P,Delacrétaz E,Allemann Y

    更新日期:2001-02-01 00:00:00

  • MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data.

    abstract::The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a randomized, double-blind, active-control trial to compare the effectiveness of two treatment regimens for the control of hypertension in reducing the rate of progression of early extracranial carotid artery atherosclerosis in hypertensive patients....

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Applegate WB,Byington RP

    更新日期:1991-02-01 00:00:00

  • Dietary calcium, vascular reactivity, and genetic hypertension in the Lyon rat strain.

    abstract::In order to examine the relationship existing between dietary calcium and the development of hypertension, we developed a long-term study in the Lyon hypertensive rat strain (LH) and two control strains, the Lyon normotensive (LN) and low blood pressure rats (LL) given enriched (HCa, 2.5%), deprived (LCa, 0.03%) and n...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pernot F,Schleiffer R,Bergmann C,Vincent M,Sassard J,Gairard A

    更新日期:1990-11-01 00:00:00

  • Prolonged effects of short-term fosinopril on blood pressure and vascular morphology and function in rats.

    abstract::The aim of this study was to evaluate the delayed effects of an angiotensin converting enzyme (ACE) inhibitor on blood pressure and on structural and functional alterations in mesenteric small resistance arteries of spontaneously hypertensive rats (SHR). The ACE inhibitor fosinopril (25 mg/kg/day) was administered acc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rizzoni D,Castellano M,Porteri E,Bettoni G,Muiesan ML,Cinelli A,Zulli R,Rosei EA

    更新日期:1997-09-01 00:00:00

  • Insulin resistance in secondary hypertension.

    abstract::The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower ins...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shamiss A,Carroll J,Rosenthal T

    更新日期:1992-01-01 00:00:00

  • Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure.

    abstract:BACKGROUND:We previously showed that the infusion of tumor necrosis factor alpha (TNF-alpha) induces hypertension and vascular dysfunction in late pregnant but not virgin rats. In the present study, we tested the hypothesis that levels of ovarian hormones to mimic pregnancy are required for TNF-alpha-induced changes in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: LaMarca BD,Chandler DL,Grubbs L,Bain J,McLemore GR Jr,Granger JP,Ryan MJ

    更新日期:2007-11-01 00:00:00

  • Twenty-four-hour blood pressure control with isradipine in mild essential hypertension.

    abstract::The hypotensive effect of isradipine was assessed in 26 male patients, aged 40 to 64 years, with hypertension. After withdrawal of previous antihypertensive treatment and a four-week placebo period, patients were randomized into a double-blind active-treatment period of eight weeks to receive either placebo or 1.25 to...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Viskoper JR,Laszt A,Faraggi D

    更新日期:1991-02-01 00:00:00

  • Plasma-renin response to isotonic volume contraction in young salt-sensitive normotensive men.

    abstract::Salt-sensitive persons have lower plasma renin activity than salt-resistant persons and their plasma renin activity increases less with a low sodium diet or volume depletion, compared to salt-resistant individuals. However, the time course of the renin response to acute volume contraction has not been studied in human...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Schorr U,Schultz C,Sharma AM

    更新日期:2002-01-01 00:00:00