Abstract：
:Concentrations of sodium-transport inhibitors (STI) which block the sodium-potassium-ATPase pump are increased in the plasma and urine of volume-expanded and low-renin hypertensive humans and animals. To evaluate the physiologic relevance of STI to blood-pressure-raising mechanisms, we have examined the in vitro properties of STI extracted from the urine of human subjects. STI produced a significant (by ANOVA: P less than .01) dose-contraction response in the isolated rabbit femoral artery. Moreover, small noncontractile doses of STI in this in vitro preparation produced a fivefold leftward shift in the contraction dose-response curve of norepinephrine (P less than .01) and a threefold shift for angiotensin II (P less than .01); at lower, physiologic, concentrations of these vasoconstrictor hormones the amplifications in contraction caused by STI ranged from 100% to 500%. In studies in calcium-free tissue bath solutions, the direct contractile action of STI was abolished; however, its amplification of responses to norepinephrine remained, suggesting that this latter effect of STI is not entirely dependent upon calcium influx into vascular smooth muscle cells. The glycoside ouabain produced effects identical to those of STI in arteries, but its actions on a rabbit atrium preparation were different: ouabain stimulated powerful inotropic effects, whereas human STI failed to cause myocardial contractions even though the amounts of STI administered had the same sodium-transport inhibitory capacity as the ouabain. Thus, the actions of human STI are primarily in the peripheral circulation, where they directly produce arterial contractions and also enhance contractile responses to other pressor hormones, suggesting that they may have a role in regulating systemic blood pressure.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Weber MA,Weiler E,Gonick HC,Prins BA,Purdy REdoi
10.1093/ajh/2.10.754subject
Has Abstractpub_date
1989-10-01 00:00:00pages
754-61issue
10eissn
0895-7061issn
1941-7225journal_volume
2pub_type
杂志文章abstract：BACKGROUND:Central aortic blood pressure (CBP) and CBP-derived parameters are independent predictors of cardiovascular risk. Angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors plus calcium channel blockers are the recommended first-line treatments in hypertensive diabetic patients; howe...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1093/ajh/hpw033
更新日期：2016-09-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：American journal of hypertension
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更新日期：2017-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/ajh/7.6.520
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journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析,评审
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更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1998-03-01 00:00:00
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更新日期：2001-09-01 00:00:00
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journal_title：American journal of hypertension
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更新日期：2016-12-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.03.747
更新日期：2005-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hpu189
更新日期：2015-05-01 00:00:00
abstract：:Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-D...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/S0895-7061(96)00254-3
更新日期：1996-12-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/4.5.464
更新日期：1991-05-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：1998-03-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/6.9.763
更新日期：1993-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-05-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ajh/1.2.158
更新日期：1988-04-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章,评审
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更新日期：1994-10-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：1999-07-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：1997-10-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
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更新日期：2019-08-14 00:00:00
abstract：BACKGROUND:Increases in blood pressure were reported in overworked public workers following the Mid-Niigata earthquake. This study aimed to compare blood pressure changes between public employees and the general population after the Great East Japan Earthquake of March 2011. METHODS:We analyzed 1,776 individuals from ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt065
更新日期：2013-09-01 00:00:00
