New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

Abstract:

BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-old man who developed severe resistant hypertension despite the use of 6 antihypertensive medications, including diuretics. He had metabolic alkalosis and hypokalemia with suppressed plasma renin activity and serum aldosterone. Concurrently, he was diagnosed with small cell neuroendocrine carcinoma of the prostate gland, a rare form of prostate cancer. Despite absence of typical Cushingoid features, investigation confirmed the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome from neuroendocrine prostate cancer. Because of the severity of his hypercortisolism, he underwent urgent bilateral adrenalectomy for hormonal and symptomatic control. Blood pressure improved significantly and he was dismissed with a single antihypertensive agent. Unfortunately, the patient died from his cancer 1 month later. CONCLUSION:Primary and secondary hyperaldosteronism are usually diagnosed based on measurements of aldosterone and plasma renin activity. However, if plasma renin activity and aldosterone are both low, rare causes of mineralocorticoid excess such as ectopic ACTH syndrome should be entertained.

journal_name

Am J Hypertens

authors

Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

doi

10.1093/ajh/hpz125

subject

Has Abstract

pub_date

2019-11-15 00:00:00

pages

1214-1217

issue

12

eissn

0895-7061

issn

1941-7225

pii

5540054

journal_volume

32

pub_type

  • Vitamin D and subsequent systolic hypertension among women.

    abstract:BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.226

    authors: Griffin FC,Gadegbeku CA,Sowers MR

    更新日期:2011-03-01 00:00:00

  • Effects of hypertrophy and heart failure on [Na+]i in pressure-overloaded guinea pig heart.

    abstract::Intracellular free sodium levels ([Na+]i) were assessed with 23Na nuclear magnetic resonance (NMR) spectroscopy in isolated, Langendorff-perfused normal, compensated hypertrophied, and hypertrophied failing guinea pig hearts under several conditions. Baseline [Na+]i measured with a shift reagent was significantly grea...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00219-F

    authors: Jelicks LA,Siri FM

    更新日期:1995-09-01 00:00:00

  • Clinical experience with intravenous fenoldopam.

    abstract::Fenoldopam (Corlopam), a new dopaminergic agent in clinical development by SmithKline Beecham Pharmaceuticals, is a dopamine-1 (DA1) agonist at post-synaptic dopamine receptors. Preclinical and clinical studies have demonstrated that it is a potent renal vasodilator as well as a peripheral vasodilator. In both normal ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/3.6.120s

    authors: Holcslaw TL,Beck TR

    更新日期:1990-06-01 00:00:00

  • Nifedipine ameliorates ischemia-induced revascularization in diet-induced obese mice.

    abstract:BACKGROUND:Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Nifedipine, a calcium-channel blocker, has a number of blood pressure (BP)-independent effects as well, such as improving endothelial function and decreasing oxidative stress. Here, we inve...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.239

    authors: Kito T,Shibata R,Kondo M,Yamamoto T,Suzuki H,Ishii M,Murohara T

    更新日期:2012-04-01 00:00:00

  • Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?

    abstract:BACKGROUND:The X-linked angiotensin II type-2 receptor (AT2R) gene 1675G/A polymorphism is located in the short intron 1 of the AT2R gene within a sequence motif conforming to a splice branch site. AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenot...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.151

    authors: Liu YP,Kuznetsova T,Thijs L,Jin Y,Schmitz B,Brand SM,Brand E,Manunta P,Bianchi G,Struijker-Boudier H,Staessen JA

    更新日期:2011-12-01 00:00:00

  • Antihypertensive therapy and cardiovascular disease. Impact of effective therapy on disease progression.

    abstract::Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(97)00422-6

    authors: Black HR

    更新日期:1998-01-01 00:00:00

  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.

    abstract::To evaluate the clinical importance of serum hepatocyte growth factor (HGF) concentration, we designed two clinical investigations. The first study analyzed the correlation between serum HGF concentration and clinical arterial stiffness or the vasodilator response to reactive hyperemia in hypertensive patients. The se...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02274-4

    authors: Komai N,Ohishi M,Morishita R,Moriguchi A,Kaibe M,Matsumoto K,Rakugi H,Higaki J,Ogihara T

    更新日期:2002-06-01 00:00:00

  • In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosterone acetate-salt hypertensive rats.

    abstract::Endothelin-1 is a potent vasoconstrictor peptide produced in blood vessels and other tissues that may play an important role in the control of local blood flow and could be involved in the pathogenesis of hypertension. Our previous studies have documented increases in endothelin-1 peptide content and gene expression i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)96213-4

    authors: Day R,Larivière R,Schiffrin EL

    更新日期:1995-03-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract::Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00440-8

    authors: Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期:1996-06-01 00:00:00

  • Red blood cell Na+/H+ and Li+/Na+ exchange in patients with essential hypertension.

    abstract::The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.12.903

    authors: Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

    更新日期:1989-12-01 00:00:00

  • Is endothelial function of the radial artery altered in human essential hypertension?

    abstract::There is controversy over whether endothelial function is impaired in human essential hypertension. All studies to date have used measurements of forearm blood flow by plethysmography to assess endothelium-dependent vasodilation and endothelial function. In contrast to these studies, which have focused on resistance v...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(96)00414-1

    authors: Schmieder RE,Weihprecht H,Schobel H,John S,Weidinger G,Gatzka C,Veelken R

    更新日期:1997-03-01 00:00:00

  • Impact of Percutaneous Revascularization on Left Ventricular Mass and Its Relationship to Outcome in Hypertensive Patients With Renal Artery Stenosis.

    abstract:BACKGROUND:We investigated the effects of percutaneous transluminal renal angioplasty on left ventricular (LV) mass, and the impact of LV mass reduction on outcomes. METHODS:A total of 144 hypertensive patients with renal artery stenosis (RAS) (mean age 69 years; 22.2% fibromuscular dysplasia (FMD)) who underwent angi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa036

    authors: Iwashima Y,Fukuda T,Horio T,Kusunoki H,Hayashi SI,Kamide K,Kawano Y,Ishimitsu T,Yoshihara F

    更新日期:2020-05-21 00:00:00

  • Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension.

    abstract::Inhibition of calcineurin-mediated signaling in T lymphocytes is a major mechanism of cyclosporine A (CsA)-induced immunosuppression, and previous rat studies have suggested that inhibition of calcineurin-mediated signaling in central neuronal pools involved in blood pressure regulation plays an important role in caus...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(00)00288-0

    authors: Zhang W,Victor RG

    更新日期:2000-09-01 00:00:00

  • Oil and water? Economic advantage and biomedical progress do not mix well in a government guidelines committee.

    abstract::This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/0895-7061(94)P1709-9

    authors: Ménard J

    更新日期:1994-10-01 00:00:00

  • Aspirin test for differentiation of unilateral renovascular hypertension from hyperreninemic essential hypertension.

    abstract::Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT). The two studies involved ten patients with unilateral RVH, eight with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.9.761

    authors: Imanishi M,Ohta M,Kawamura M,Akabane S,Matsushima Y,Kuramochi M,Kojima S,Kimura K,Takamiya M,Ito K

    更新日期:1991-09-01 00:00:00

  • Neural control of renin release.

    abstract::Among the major mechanisms controlling the renal release of renin, renal nerves are known to exert a direct stimulating action on juxtaglomerular cells that is mediated by beta-adrenoceptors. Activation of the renal nerves also exerts an important permissive role in order to amplify and possibly accelerate responses t...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/2.2.7s

    authors: Stella A,Golin R,Zanchetti A

    更新日期:1989-02-01 00:00:00

  • Unsweetening the Heart: Possible Pleiotropic Effects of SGLT2 Inhibitors on Cardio and Cerebrovascular Alterations in Resistant Hypertensive Subjects.

    abstract::Resistant hypertension (RH) is a multifactorial disease associated with several target organ damage, such as microalbuminuria, left ventricular hypertrophy, and arterial stiffness. These subjects have high cardiovascular complications, especially when associated with diabetes condition. Sodium glucose cotransporter 2 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/hpx204

    authors: Pioli MR,Ritter AMV,Modolo R

    更新日期:2018-02-09 00:00:00

  • Epicardial coronary artery size in hypertensive and physiologic left ventricular hypertrophy.

    abstract:BACKGROUND:In the hypertensive heart, epicardial arteries are not enlarged, despite increased total coronary flow related to augmented cardiac workload, wall stress, and left ventricular (LV) mass. The aims of this study were to assess the impact of different hemodynamic factors and LV mass on baseline left main corona...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.07.003

    authors: Kozakova M,Paterni M,Bartolomucci F,Morizzo C,Rossi G,Galetta F,Palombo C

    更新日期:2007-03-01 00:00:00

  • Use of an automated blood pressure recording device, the BpTRU, to reduce the "white coat effect" in routine practice.

    abstract:BACKGROUND:Patients often exhibit higher blood pressure (BP) readings in the doctor's office, a phenomenon known as the white coat effect. This study examines the presence of a physician in the examining room as a possible factor in provoking a white coat effect. METHODS:Blood pressure measurements taken by an automat...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(03)00058-x

    authors: Myers MG,Valdivieso MA

    更新日期:2003-06-01 00:00:00

  • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.

    abstract:BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt277

    authors: Tapia-Castillo A,Carvajal CA,Campino C,Vecchiola A,Allende F,Solari S,García L,Lavanderos S,Valdivia C,Fuentes C,Lagos CF,Martínez-Aguayo A,Baudrand R,Aglony M,García H,Fardella CE

    更新日期:2014-03-01 00:00:00

  • How should we treat hypertensive women with cardiac and renal impairment?

    abstract::Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke. Its importance as a cardiovascular risk factor is at least as significant in women as in men; however, the ever-growing lit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(97)00330-0

    authors: Ruilope LM,Suarez C

    更新日期:1997-10-01 00:00:00

  • Aerobic exercise training fails to reduce blood pressure in nondipper-type hypertension.

    abstract::To assess whether aerobic exercise training is an effective and an alternative method to control blood pressure (BP) in hypertension, 32 uncomplicated, never treated patients suffering from mild-to-moderate essential arterial hypertension (EAH) were included in an aerobic exercise training program using a regular stan...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00265-4

    authors: Nami R,Mondillo S,Agricola E,Lenti S,Ferro G,Nami N,Tarantino M,Glauco G,Spanò E,Gennari C

    更新日期:2000-06-01 00:00:00

  • Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor.

    abstract::Neutral metalloendopeptidase (NEP) inhibitors delay atrial natriuretic factor (ANF) catabolism and potentiate biological responses to ANF. We describe biochemical and pharmacological profiles of a novel NEP inhibitor, SCH 42354 (N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-4-oxopropyl]-L-methionine and its orally activ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/6.5.357

    authors: Watkins RW,Vemulapalli S,Chiu PJ,Foster C,Smith EM,Neustadt B,Haslanger M,Sybertz EJ

    更新日期:1993-05-01 00:00:00

  • Training students in education of the hypertensive patient: enhanced performance after a simulated patient instructor (SPI)-based exercise.

    abstract::The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00034-x

    authors: Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

    更新日期:1998-05-01 00:00:00

  • Influences of different antihypertensive treatments on indices of systemic mineral metabolism.

    abstract::A negative calcium balance has previously been described in human hypertension with low levels of plasma ionized calcium (Ca2+) and an increased urinary excretion of calcium. The cause of this disturbance in mineral metabolism is not known, nor is it known if this derangement could be abolished if blood pressure is re...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.4.302

    authors: Lind L,Hänni A,Hvarfner A,Pollare T,Ljunghall S,Lithell H

    更新日期:1994-04-01 00:00:00

  • Results of the multicenter antihypertensive treatment trials. Therapeutic implications and the role of the sympathetic nervous system.

    abstract::The results of 19 antihypertensive treatment trials spanning some 20 years of research showed that treatment had significant benefits for pressure-related complications of hypertension but generally did not prevent coronary artery disease morbidity or mortality. As possible reasons for this relative failure were explo...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,评审

    doi:10.1093/ajh/2.12.313s

    authors: Rosenman RH

    更新日期:1989-12-01 00:00:00

  • Specific genetic influences on nighttime blood pressure.

    abstract:OBJECTIVES:Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1093/ajh/hpu162

    authors: Xu X,Su S,Treiber FA,Vlietinck R,Fagard R,Derom C,Gielen M,Loos RJ,Snieder H,Wang X

    更新日期:2015-04-01 00:00:00

  • Hemodynamic responses to verapamil monotherapy in patients with renal disease.

    abstract::We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.12.939

    authors: Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

    更新日期:1991-12-01 00:00:00

  • Aldosterone Antagonists or Renin-Guided Therapy for Treatment-Resistant Hypertension: A Comparative Effectiveness Pilot Study in Primary Care.

    abstract:BACKGROUND:Uncontrolled treatment-resistant hypertension (TRH), i.e., blood pressure (BP, mm Hg) ≥140/≥90mm Hg in and out of office on ≥3 different BP medications at optimal doses, is common and has a poor prognosis. Aldosterone antagonist (AA) and renin-guided therapy (RGT) are effective strategies for improving BP co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpw016

    authors: Egan BM,Laken MA,Sutherland SE,Qanungo S,Fleming DO,Cook AG,Hester WH,Jones KW,Jebaily GC,Valainis GT,Way CF,Wright MB,Davis RA

    更新日期:2016-08-01 00:00:00

  • Silent cerebral infarcts in basal ganglia are advanced in congenital protein C-deficient heterozygotes with hypertension.

    abstract::Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(01)02046-5

    authors: Kario K,Sakata T,Higashikawa M,Katayama Y,Hoshide S,Shimada K,Miyata T

    更新日期:2001-08-01 00:00:00