Vitamin D and subsequent systolic hypertension among women.


BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes 559 women aged 24-44 years in 1992; annual blood pressure (BP) measurements and data collection began in 1992 and is ongoing. A single-time serum 25(OH)D level was measured in 1993. Using logistic regression, vitamin D insufficiency (<80 nmol/l) was related to systolic hypertension (≥140 mm Hg) measures identified in 1993 and in 2007. Further, the relationship between vitamin D at baseline and the trajectory of systolic BP across the ensuing 14 years was assessed using longitudinal mixed modeling. RESULTS:Vitamin D insufficiency was not significantly associated with concurrent systolic hypertension in 1993 (odds ratio (OR) 1.3; 95% confidence interval (CI) (0.32, 5.1)). However, vitamin D insufficiency was associated with increased risk of systolic hypertension in 2007 (OR 3.0; 95% CI (1.01, 8.7)) after adjusting for age, body fat percentage, antihypertensive medication use, and smoking. Baseline vitamin D status was not associated with rate of BP change over the 14-year period. CONCLUSIONS:Consistent with previous animal and human studies, we found a single-time measure of vitamin D among young adult women was associated with systolic hypertension 14 years later. These prospective results suggest the need for further study of the role vitamin D insufficiency in early adulthood as a risk factor in subsequent hypertension among women.


Am J Hypertens


Griffin FC,Gadegbeku CA,Sowers MR




Has Abstract


2011-03-01 00:00:00














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    pub_type: 杂志文章


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    pub_type: 杂志文章,多中心研究


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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:1992-12-01 00:00:00

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    更新日期:2015-04-01 00:00:00

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    更新日期:2004-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2007-06-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Umeda M,Ichikawa S,Kanda T,Sumino H,Kobayashi I

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    更新日期:2003-04-01 00:00:00