Hemodynamic and renal effects of indomethacin in losartan-treated hypertensive individuals.

abstract：:The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...

journal_title：American journal of hypertension

authors： O'Hagan KP,Thomas GD,Zambraski EJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

journal_title：American journal of hypertension

authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

更新日期：2011-03-01 00:00:00

abstract：:To evaluate the existence of a relationship between atrial natriuretic factor (ANF) and plasma Na+/K+ATPase inhibitory activity in humans, we examined the hemodynamic and humoral response to volume expansion in 41 borderline hypertensive patients (BHT) with either normal (n = 33) or low plasma renin activity (n = 8). ...

journal_title：American journal of hypertension

authors： Borghi C,Boschi S,Costa FV,Ambrosioni E

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Pulse pressure/stroke volume indexed to height(2.04) (PP/SVi) is a validated measure of arterial stiffness, but its relation to carotid atherosclerosis is unknown. METHODS:Clinical, echocardiographic, and carotid ultrasound data from 6,209 hypertensive patients without prevalent cardiovascular (CV) disease ...

journal_title：American journal of hypertension

authors： Casalnuovo G,Gerdts E,de Simone G,Izzo R,De Marco M,Giudice R,Trimarco B,De Luca N

更新日期：2012-07-01 00:00:00

abstract：:Resistant hypertension (RH) is a multifactorial disease associated with several target organ damage, such as microalbuminuria, left ventricular hypertrophy, and arterial stiffness. These subjects have high cardiovascular complications, especially when associated with diabetes condition. Sodium glucose cotransporter 2 ...

journal_title：American journal of hypertension

authors： Pioli MR,Ritter AMV,Modolo R

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Overweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augm...

journal_title：American journal of hypertension

authors： Kalfon R,Campbell J,Alvarez-Alvarado S,Figueroa A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

journal_title：American journal of hypertension

authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

更新日期：2008-11-01 00:00:00

abstract：:The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

journal_title：American journal of hypertension

authors： Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

更新日期：1990-06-01 00:00:00

abstract：:Great pathophysiological significance has recently been placed on the association of metabolic abnormalities, such as hyperinsulinemia, insulin resistance, obesity, and frank diabetes mellitus, with essential hypertension and coronary artery disease, and the clinical coincidence of these features has been termed "synd...

journal_title：American journal of hypertension

authors： Resnick LM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Osteopontin (Opn) is highly upregulated in many different animal models of renal disease, where it is suspected to participate in progression of the disease. In some models, angiotensin II (Ang II) seems to induce the elevated Opn production. Therefore, we examined the regulation of Opn in two-kidney, one-cl...

journal_title：American journal of hypertension

authors： Gauer S,Hartner A,Hauser IA,Fierlbeck W,Eberhardt W,Geiger H

更新日期：2003-03-01 00:00:00

abstract：:Hypertension is a major risk factor for cardiovascular disease, and small reductions in blood pressure can have a substantial impact on outcome. Effective control of hypertension per se is important in reducing morbidity and mortality, but there is growing evidence that the class of drug used in treatment may affect p...

journal_title：American journal of hypertension

authors： Oparil S

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Insulin resistance (IR) and the metabolic syndrome (MetS) may contribute to cardiovascular risk in chronic kidney disease (CKD). We examine the association between IR and vascular function in CKD. Furthermore, we define the prevalence of MetS and examine the association between defining MetS and vascular fun...

journal_title：American journal of hypertension

authors： Chan DT,Watts GF,Irish AB,Ooi EM,Dogra GK

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Clonidine, a centrally acting antihypertensive agent, has been used successfully in pregnancy. We sought to describe the pharmacodynamic effects of clonidine in pregnancy and the associated impact on fetal growth. METHODS:A retrospective cohort study was performed. Maternal hemodynamics were measured before...

journal_title：American journal of hypertension

authors： Rothberger S,Carr D,Brateng D,Hebert M,Easterling TR

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

journal_title：American journal of hypertension

authors： Notarius CF,Morris BL,Floras JS

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS:In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and fo...

journal_title：American journal of hypertension

authors： Casiglia E,Tikhonoff V,Boschetti G,Bascelli A,Saugo M,Guglielmi G,Caffi S,Rigoni G,Giordano N,Grasselli C,Martini B,Mazza A,De Lazzari F,Palatini P

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Aortic pulse wave velocity (PWV) is a measure of arterial stiffness and has proved useful in predicting cardiovascular morbidity and mortality in several populations of patients, including the healthy elderly, hypertensives and those with end-stage renal disease receiving hemodialysis. Little data exist char...

journal_title：American journal of hypertension

authors： Townsend RR,Wimmer NJ,Chirinos JA,Parsa A,Weir M,Perumal K,Lash JP,Chen J,Steigerwalt SP,Flack J,Go AS,Rafey M,Rahman M,Sheridan A,Gadegbeku CA,Robinson NA,Joffe M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that tamoxifen, which belongs to a group called selective estrogen receptor modulators (SERM), may exert protective effects against cardiovascular diseases and stroke in postmenopausal women. On the other hand, abnormalities in physical properties of the cell membranes may underlie ...

journal_title：American journal of hypertension

authors： Tsuda K,Nishio I

更新日期：2005-08-01 00:00:00

abstract：:Decreased urinary kallikrein excretion has been shown to be related to hypertension. Kallikrein levels also have been shown to be determined primarily by genes, with 51% of the total variance being due to a single gene. However, there exists strong spouse-spouse correlation, indicating that common environment plays a ...

journal_title：American journal of hypertension

authors： Hunt SC,Wu LL,Slattery ML,Meikle AW,Williams RR

更新日期：1993-03-01 00:00:00

abstract：:Cocaine causes acute hypertension by blocking catecholamine reuptake. There is evidence that it also impairs the peripheral endothelial nitric oxide system, which is normally vasodilatory. We further explored the role of nitric oxide in cocaine-induced vasoconstriction in anesthetized rats, and in vitro by using isola...

journal_title：American journal of hypertension

authors： Mo W,Singh AK,Arruda JA,Dunea G

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:The question of whether reduced sodium intake is effective as a health prophylaxis initiative is unsolved. The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids. METHODS:Studies randomizing persons to low-sodium an...

journal_title：American journal of hypertension

authors： Graudal NA,Hubeck-Graudal T,Jürgens G

更新日期：2012-01-01 00:00:00

abstract：:Abnormal calcium metabolism has been implicated in human hypertension. Caffeine consumption may contribute to hypertension since it increases urinary calcium excretion. Nineteen hypertensive subjects (HTN) and nineteen age and gender matched normotensive controls (NTC) who habitually consumed at least 175 mg caffeine ...

journal_title：American journal of hypertension

authors： Wise KJ,Bergman EA,Sherrard DJ,Massey LK

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Ionized magnesium levels are elevated in fetal blood compared with maternal blood, suggesting that the placenta may possess an active transport mechanism for magnesium. In the present study, we sought to determine the existence of an active transport mechanism for magnesium in the placenta using cultured tro...

journal_title：American journal of hypertension

authors： Standley PR,Standley CA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...

journal_title：American journal of hypertension

authors： Brosnan MJ,Carkner RD

更新日期：2008-06-01 00:00:00

abstract：:While only a small percentage of the population has high blood pressure, a much larger segment of the US population has a high-normal (above optimal) blood pressure, and is at increased risk for hypertension and its cardiovascular sequelae. Hypertension is thus a population-wide problem and must be approached in much ...

journal_title：American journal of hypertension

authors： Stamler J

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...

journal_title：American journal of hypertension

authors： Hill LK,Sherwood A,Blumenthal JA,Hinderliter AL

更新日期：2016-12-01 00:00:00

abstract：:Antihypertensive drugs are often initiated and adjusted over a period of weeks to months. It is not clear whether the time and inconvenience of this approach is necessary. We studied whether or not drug adjustment over several days in the context of a physician-nurse team could produce a durable blood pressure benefit...

journal_title：American journal of hypertension

authors： Canzanello VJ,Jensen PL,Hunder I

更新日期：2001-04-01 00:00:00

abstract：:Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...

journal_title：American journal of hypertension

authors： McCarron DA,Heaney RP

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...

journal_title：American journal of hypertension

authors： Cacciolati C,Hanon O,Alpérovitch A,Dufouil C,Tzourio C

更新日期：2011-06-01 00:00:00

abstract：:The role of dietary salt and calcium on changes in cellular cation metabolism has been evaluated in 11 salt-sensitive hypertensive black adults maintained on the following four metabolic diets for 56 days, 14 days on each diet in a repeated measures format: 356 mg Ca-1000 mg sodium (NA); 356 mg Ca-4000 mg Na; 934 Ca-1...

journal_title：American journal of hypertension

authors： Zemel MB,Kraniak J,Standley PR,Sowers JR

更新日期：1988-10-01 00:00:00

abstract：:Vasoconstrictor and Na/K pump inhibitory properties of a bufodienolide Na/K-ATPase inhibitor, marinobufagenin, were studied in isolated rings of 2 to 3 order branches of human pulmonary arteries respectively. Marinobufagenin displayed concentration-dependent vasoconstrictor activity (0.01 to 10 mmol/L). In sarcolemma ...

journal_title：American journal of hypertension

authors： Bagrov AY,Dmitrieva RI,Fedorova OV,Kazakov GP,Roukoyatkina NI,Shpen VM

更新日期：1996-10-01 00:00:00