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Arterial stiffness is associated with carotid atherosclerosis in hypertensive patients (the Campania Salute Network).

Abstract：

BACKGROUND:Pulse pressure/stroke volume indexed to height(2.04) (PP/SVi) is a validated measure of arterial stiffness, but its relation to carotid atherosclerosis is unknown. METHODS:Clinical, echocardiographic, and carotid ultrasound data from 6,209 hypertensive patients without prevalent cardiovascular (CV) disease in the Campania Salute Network were analyzed. The population was grouped into tertiles of PP/SVi. From carotid ultrasound, peak and mean intima-media thickness (IMT) and presence of carotid plaques in the common and internal carotid arteries were reported. RESULTS:Increasing PP/SVi tertile was associated with a parallel increase in age, blood pressure, total serum cholesterol and the number of antihypertensive drugs used (all P < 0.01). Higher PP/SVi was also associated with greater peak and mean IMT (all P < 0.01), also when adjusting for age, gender, blood pressure, lipid profile, and diabetes mellitus (all P < 0.01). Similarly, compared to the lower PP/SVi tertile, the multiple adjusted prevalence ratio of carotid plaque was 7 (95% confidence interval (CI) 1-13, P < 0.03) in the middle tertile and 21 (95% CI 15-28, P < 0.0001) in the upper tertile, independently of confounders. CONCLUSION:In treated hypertensive patients participating in the Campania Salute Network, higher PP/SVi is associated with carotid atherosclerosis independent of well-known clinical confounders.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Casalnuovo G,Gerdts E,de Simone G,Izzo R,De Marco M,Giudice R,Trimarco B,De Luca N

doi

10.1038/ajh.2012.38

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

739-45

issue

7

eissn

0895-7061

issn

1941-7225

pii

ajh201238

journal_volume

25

pub_type

杂志文章

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