Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C.

abstract：BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...

journal_title：American journal of hypertension

authors： Hare JL,Sharman JE,Leano R,Jenkins C,Wright L,Marwick TH

更新日期：2013-05-01 00:00:00

abstract：:It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

journal_title：American journal of hypertension

authors： Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Expression of matrix metalloproteinase (MMP) has been shown in aortic dissection and aneurysms indicating increased proteolysis compared with the normal aorta. However, its role in the development of aortic root dilatation has not been studied. We therefore attempted to determine the relationship between aor...

journal_title：American journal of hypertension

authors： Karakaya O,Barutcu I,Esen AM,Dogan S,Saglam M,Karapinar H,Akgun T,Karavelioglu Y,Esen O,Ozdemir N,Turkmen S,Kaymaz C

更新日期：2006-04-01 00:00:00

abstract：:We tested the reproducibility of ambulatory blood pressure monitoring (ABPM) by the use of agreement plots. Thirty-two normotensive volunteers underwent ABPM on four separate days (interval 28 days), on the same typical weekday. Sleeping time was restricted to the ABPM nighttime subperiod from 11:00 PM to 7:00 AM. Twe...

journal_title：American journal of hypertension

authors： Musso NR,Vergassola C,Barone C,Lotti G

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with primary aldosteronism and, to a lesser degree, subjects with resistant hypertension. METHODS:In current analysis, we examined the antihypertensive benefit of adding low-dose spironolactone to mu...

journal_title：American journal of hypertension

authors： Nishizaka MK,Zaman MA,Calhoun DA

更新日期：2003-11-01 00:00:00

abstract：:The results of 19 antihypertensive treatment trials spanning some 20 years of research showed that treatment had significant benefits for pressure-related complications of hypertension but generally did not prevent coronary artery disease morbidity or mortality. As possible reasons for this relative failure were explo...

journal_title：American journal of hypertension

authors： Rosenman RH

更新日期：1989-12-01 00:00:00

abstract：:Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...

journal_title：American journal of hypertension

authors： Coats AJ,Conway J,Sleight P,Meyer TE,Somers VK,Floras JS,Vann Jones J

更新日期：1991-03-01 00:00:00

abstract：:Molecular evidence, using DNA fingerprint analyses, of extensive genetic heterogeneity between spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and even within some of the WKY colonies has been reported. Thus we investigated the genetic relations between Dahl S and R rats newly inbred by Dr. Iwai. Gen...

journal_title：American journal of hypertension

authors： Umemura S,Yamaguchi S,Hayashi S,Nyui N,Yokoyama N,Sumita YI,Hibi K,Yabana M,Kihara M,Tamura K,Ishigami T,Ishii M

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Recently, the central augmentation index (AIx) has been reported to show a nonlinear correlation with age. We investigated whether the AIx of the central artery changes with the progression of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. METHODS:We simultaneously recorded pre...

journal_title：American journal of hypertension

authors： Katsuda S,Miyake M,Kobayashi D,Hazama A,Kusanagi M,Takazawa K

更新日期：2013-03-01 00:00:00

abstract：:Decreased urinary kallikrein excretion has been shown to be related to hypertension. Kallikrein levels also have been shown to be determined primarily by genes, with 51% of the total variance being due to a single gene. However, there exists strong spouse-spouse correlation, indicating that common environment plays a ...

journal_title：American journal of hypertension

authors： Hunt SC,Wu LL,Slattery ML,Meikle AW,Williams RR

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:On the basis of evidence of plasma leptin (LE) effects on cardiovascular system, we assessed possible association of LE and Doppler-derived left ventricular (LV) diastolic function in arterial hypertension. METHODS:Doppler echocardiography, blood sample for fasting plasma LE levels, and euglycemic hyperinsu...

journal_title：American journal of hypertension

authors： Galderisi M,Tagliamonte MR,D'Errico A,Carella C,Varricchio G,Mondillo S,de Divitiis O,Paolisso G

更新日期：2001-10-01 00:00:00

abstract：:Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

journal_title：American journal of hypertension

authors： Kahn AM,Allen JC,Seidel CL,Song T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:African-American men have stiffer arteries than white men at rest. We sought to test the hypothesis that reductions in stiffness after aerobic exercise may be attenuated in African-American (AA) men compared with white (W) men. METHODS:Twenty-four young men (age 22+/-1.0 years; 12 AA and 12 W) underwent mea...

journal_title：American journal of hypertension

authors： Heffernan KS,Jae SY,Fernhall B

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Coffee is a rich source of antioxidative polyphenols, but epidemiological studies and interventional trials have failed to demonstrate any clear beneficial effects of coffee consumption on hypertension. The interaction between hydroxyhydroquinone (HHQ) and 5-caffeoylquinic acid (CQA) was examined, in an atte...

journal_title：American journal of hypertension

authors： Suzuki A,Fujii A,Jokura H,Tokimitsu I,Hase T,Saito I

更新日期：2008-01-01 00:00:00

abstract：:In this study we have compared Ca2+ efflux in cultured aortic smooth muscle cells derived from male, 10-week-old spontaneously hypertensive and Wistar-Kyoto rats. The role of Ca(2+)-dependent protein kinase C and Ca2+ uptake in the regulation of the Ca2+ pump and Na(+)-Ca2+ exchange mediated Ca2+ efflux were investiga...

journal_title：American journal of hypertension

authors： Chen S,Monteith GR,Roufogalis BD

更新日期：1995-10-01 00:00:00

abstract：:The altered membrane microviscosity demonstrated in various cells of spontaneously hypertensive rats (SHR) and essential hypertensive (EH) patients has been proposed to play an important role in the pathogenesis of genetic forms of hypertension. The aim of this study was to evaluate possible changes of membrane microv...

journal_title：American journal of hypertension

authors： Le Quan Sang KH,Kunes J,Zicha J,Vincent M,Sassard J,Devynck MA

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) responses to dietary sodium and potassium intake vary among individuals. We examined the correlation between BP responses to dietary low-sodium, high-sodium, and potassium supplementation interventions in a feeding study. METHODS:A total of 1,906 Chinese aged > or = 16 years participated...

journal_title：American journal of hypertension

authors： Zhao Q,Gu D,Chen J,Bazzano LA,Rao DC,Hixson JE,Jaquish CE,Cao J,Chen J,Li J,Rice T,He J

更新日期：2009-12-01 00:00:00

abstract：:Inhibition of calcineurin-mediated signaling in T lymphocytes is a major mechanism of cyclosporine A (CsA)-induced immunosuppression, and previous rat studies have suggested that inhibition of calcineurin-mediated signaling in central neuronal pools involved in blood pressure regulation plays an important role in caus...

journal_title：American journal of hypertension

authors： Zhang W,Victor RG

更新日期：2000-09-01 00:00:00

abstract：:Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-D...

journal_title：American journal of hypertension

authors： Keen HL,Brands MW,Alonso-Galicia M,Hall JE

更新日期：1996-12-01 00:00:00

abstract：:The effects of dietary Na+ on 5 alpha- and 5 beta-reductase pathways of aldosterone metabolism in the liver were studied in male rats maintained on low, control, and high Na+ diets. A high Na+ diet caused significant increases in the synthesis of 5 beta-reduced metabolites, primarily 3 alpha, 5 beta-tetrahydroaldoster...

journal_title：American journal of hypertension

authors： Gorsline J,Latif SA,Morris DJ

更新日期：1988-07-01 00:00:00

abstract：:Several epidemiological and clinical studies have established a clear association between alcohol consumption and hypertension. The mechanism of the pressor effect of ethanol is not well understood. We studied the in vitro effects of increasing amounts of ethanol on different Na+ transport systems from human erythrocy...

journal_title：American journal of hypertension

authors： Coca A,Garay RP,Aguilera MT,De la Sierra A,Urbano-Márquez A

更新日期：1989-10-01 00:00:00

abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...

journal_title：American journal of hypertension

authors： Muntzel MS,Nyeduala B,Barrett S

更新日期：1999-12-01 00:00:00

abstract：:Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP con...

journal_title：American journal of hypertension

authors： Jin HK,Yang RH,Chen YF,Wyss JM,Oparil S

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

journal_title：American journal of hypertension

authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:As hypertension, obesity, and leanness are reported to be associated with poor cognitive function, it is possible that obesity or leanness in hypertensive patients may also be associated strongly with poor cognitive function. METHODS:We recruited 184 elderly hypertensive patients comprising 93 very elderly ...

journal_title：American journal of hypertension

authors： Sakakura K,Hoshide S,Ishikawa J,Momomura S,Kawakami M,Shimada K,Kario K

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

journal_title：American journal of hypertension

authors： Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

更新日期：2015-02-01 00:00:00

abstract：:In vivo studies suggest that 17 beta-estradiol (beta E) may regulate vascular tone. Results of recent studies suggest that beta E exerts rapid effects on intracellular calcium, possibly via cell surface receptors, distinct from conventional nuclear receptors for steroids. The present study was designed to determine wh...

journal_title：American journal of hypertension

authors： Ravi J,Mantzoros CS,Prabhu AS,Ram JL,Sowers JR

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...

journal_title：American journal of hypertension

authors： Bundy JD,Jaeger BC,Huffman MD,Knox SS,Thomas SJ,Shimbo D,Booth Iii JN,Lewis CE,Edwards LJ,Schwartz JE,Muntner P

更新日期：2020-11-17 00:00:00

abstract：:Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...

journal_title：American journal of hypertension

authors： Kario K,Sakata T,Higashikawa M,Katayama Y,Hoshide S,Shimada K,Miyata T

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:We hypothesized that high-dose active vitamin D therapy in the form of alphacalcidol (α-calcidol), used to treat secondary hyperparathyroidism in chronic kidney disease, could lead to vascular calcification and accelerated progression of aortic stiffness. METHODS:We conducted an observational study in 85 pa...

journal_title：American journal of hypertension

authors： Fortier C,Mac-Way F,De Serres SA,Marquis K,Douville P,Desmeules S,Larivière R,Agharazii M

更新日期：2014-11-01 00:00:00