High dietary salt enhances acute depressor responses to metformin.

abstract：BACKGROUND:We determined the prognostic value of the Cornell/strain [C/S] index, a simple electrocardiographic (ECG) index for left ventricular hypertrophy (LVH) defined by the presence of either a classic strain pattern or a Cornell voltage (sum of R in aVL + S in V(3)) >2.0 mV in women or 2.4 mV in men, or both. MET...

journal_title：American journal of hypertension

authors： Verdecchia P,Angeli F,Reboldi G,Carluccio E,Benemio G,Gattobigio R,Borgioni C,Bentivoglio M,Porcellati C,Ambrosio G

更新日期：2003-08-01 00:00:00

abstract：:Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke. Its importance as a cardiovascular risk factor is at least as significant in women as in men; however, the ever-growing lit...

journal_title：American journal of hypertension

authors： Ruilope LM,Suarez C

更新日期：1997-10-01 00:00:00

abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

journal_title：American journal of hypertension

authors： Levy BI

更新日期：2005-09-01 00:00:00

abstract：:The aim of the present study was to assess the efficacy and tolerability of a calcium antagonist/beta-blocker fixed combination tablet used as first-line antihypertesnive therapy in comparison with an angiotensin converting enzyme inhibitor and placebo. Patients with uncomplicated essential hypertension (diastolic blo...

journal_title：American journal of hypertension

authors： Waeber B,Detry JM,Dahlöf B,Puig JG,Gundersen T,Hosie J,Januszewicz W,Lindström CJ,Magometschnigg D,Safar M,Tanser P,Toutouzas P

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Higher fibroblast growth factor-23 (FGF23) concentrations have been found to be associated with incident heart failure (HF). Experimental data suggest FGF23 directly stimulates myocardial hypertrophy. FGF23 may also enhance renin-angiotensin-aldosterone system activity. Whether FGF23 is associated with incre...

journal_title：American journal of hypertension

authors： Akhabue E,Vu TT,Vaidya A,Michos ED,de Boer IH,Kestenbaum B,Allison M,Szklo M,Ouyang P,Yancy CW,Wolf M,Isakova T,Carnethon MR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The dopaminergic and endothelin systems, by regulating sodium transport in the renal proximal tubule (RPT), participate in the control of blood pressure. The D(3) and ETB receptors are expressed in RPTs, and D(3) receptor function in RPTs is impaired in spontaneously hypertensive rats (SHRs). Therefore, we t...

journal_title：American journal of hypertension

authors： Yu C,Yang Z,Ren H,Zhang Y,Han Y,He D,Lu Q,Wang X,Wang X,Yang C,Asico LD,Hopfer U,Eisner GM,Jose PA,Zeng C

更新日期：2009-08-01 00:00:00

abstract：:In normal coronary arteries, increased flow velocity induces endothelium-dependent dilation, and dilation in response to sympathetic stimulation evoked by the cold pressor test is partly due to increased flow velocity. In arterial hypertension, angiographically normal coronary arteries were constricted by acetylcholin...

journal_title：American journal of hypertension

authors： Nitenberg A,Antony I,Aptecar E,Arnoult F,Lerebours G

更新日期：1995-05-01 00:00:00

abstract：:Concentrations of sodium-transport inhibitors (STI) which block the sodium-potassium-ATPase pump are increased in the plasma and urine of volume-expanded and low-renin hypertensive humans and animals. To evaluate the physiologic relevance of STI to blood-pressure-raising mechanisms, we have examined the in vitro prope...

journal_title：American journal of hypertension

authors： Weber MA,Weiler E,Gonick HC,Prins BA,Purdy RE

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodel...

journal_title：American journal of hypertension

authors： Pierdomenico SD,Lapenna D,Bucci A,Manente BM,Cuccurullo F,Mezzetti A

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Ischemia-induced reactive hyperemia (RH) is mediated by various factors including release of nitric oxide (NO). The contribution of NO to RH equals the extent of L-NMMA-dependent reduction of forearm blood flow (FBF). Because the optimal duration and location of ischemia that provokes maximum NO activation i...

journal_title：American journal of hypertension

authors： Raff U,Ott C,John S,Schmidt BM,Fleischmann EH,Schmieder RE

更新日期：2010-08-01 00:00:00

abstract：:The sensitivity and specificity of screening and diagnostic studies for renovascular hypertension has been the focus of debate and disappointment for many years. The use of these studies has been further restricted by the insistence of clinicians that studies provide visual identification of the anatomy of the renal v...

journal_title：American journal of hypertension

authors： Vidt DG

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in the understanding of the management of high BP in the aged. We explored antihypertensive treatment and control among elderly hypertensive participants free from overt card...

journal_title：American journal of hypertension

authors： Chowdhury EK,Nelson MR,Ernst ME,Margolis KL,Beilin LJ,Johnston CI,Woods RL,Murray AM,Wolfe R,Storey E,Shah RC,Lockery JE,Tonkin AM,Newman AB,Williamson JD,Abhayaratna WP,Stocks NP,Fitzgerald SM,Orchard SG,Trevaks RE

更新日期：2020-04-01 00:00:00

abstract：:The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-1 receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a re...

journal_title：American journal of hypertension

authors： Uehara Y,Hirawa N,Kawabata Y,Numabe A,Gomi T,Ikeda T,Omata M

更新日期：1999-01-01 00:00:00

abstract：:Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...

journal_title：American journal of hypertension

authors： Tuck ML,Bravo EL,Krakoff LR,Friedman CP

更新日期：1990-12-01 00:00:00

abstract：:This review analyses methods and devices used worldwide to evaluate the arterial stiffness. Three main methodologies are based upon analysis of pulse transit time, of wave contour of the arterial pulse, and of direct measurement of arterial geometry and pressure, corresponding to regional, systemic and local determina...

journal_title：American journal of hypertension

authors： Pannier BM,Avolio AP,Hoeks A,Mancia G,Takazawa K

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. METHODS:We ...

journal_title：American journal of hypertension

authors： Doi Y,Iwashima Y,Yoshihara F,Kamide K,Takata H,Fujii T,Kubota Y,Nakamura S,Horio T,Kawano Y

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for the development of arterial stiffness and vascular disease, and it is related to the upregulation of matrix metalloproteinase-2 (MMP-2) in the aorta of rats and nonhuman primates. This study aimed to determine whether MMP activity in the human vasculature changes with aging. ...

journal_title：American journal of hypertension

authors： McNulty M,Spiers P,McGovern E,Feely J

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Hypertension is the most prevalent chronic disease worldwide. Lifestyle behaviors for its prevention and control are recommended within worldwide guidelines. Nevertheless, their combined relationship with blood pressure (BP) level, particularly in the general population, would need more investigations. Our a...

journal_title：American journal of hypertension

authors： Lelong H,Galan P,Kesse-Guyot E,Fezeu L,Hercberg S,Blacher J

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...

journal_title：American journal of hypertension

authors： Siddiqui AJ,Mansson-Broberg A,Gustafsson T,Grinnemo KH,Dellgren G,Hao X,Fischer H,Sylvén C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Subjects with resistant hypertension present high prevalence of a nondipper blood pressure (BP) pattern, associated with increased risk of cardiovascular events. Nondipping is partly related to the absence of 24-h therapeutic coverage in hypertensives treated with single morning doses. METHODS:We studied th...

journal_title：American journal of hypertension

authors： Hermida RC,Ayala DE,Mojón A,Fernández JR

更新日期：2010-04-01 00:00:00

abstract：:The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...

journal_title：American journal of hypertension

authors： Calzolari A,Giordano U,Matteucci MC,Pastore E,Turchetta A,Rizzoni G,Alpert B

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...

journal_title：American journal of hypertension

authors： Tapia-Castillo A,Carvajal CA,Campino C,Vecchiola A,Allende F,Solari S,García L,Lavanderos S,Valdivia C,Fuentes C,Lagos CF,Martínez-Aguayo A,Baudrand R,Aglony M,García H,Fardella CE

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS:Subjects were Blacks and Whites fro...

journal_title：American journal of hypertension

authors： Tu W,Eckert GJ,Decker BS,Howard Pratt J

更新日期：2017-05-01 00:00:00

abstract：:Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated...

journal_title：American journal of hypertension

authors： Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata K

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Epidemiologic analysis of family data on blood pressure (BP) is often compromised by the effects of antihypertensive medications. A review of numerous clinical trials that investigated the effects of BP-lowering medications is summarized here. METHODS:Published clinical trials, including 137 clinical trials...

journal_title：American journal of hypertension

authors： Wu J,Kraja AT,Oberman A,Lewis CE,Ellison RC,Arnett DK,Heiss G,Lalouel JM,Turner ST,Hunt SC,Province MA,Rao DC

更新日期：2005-07-01 00:00:00

abstract：:The principal aim of the present study was to determine the relationship of ambulatory blood pressure (BP) to urinary electrolyte excretion in normotensives. Twenty-five young adults underwent ambulatory BP and heart rate monitoring while collecting urine over 24 h. The correlations of 24 h urine sodium excretion and ...

journal_title：American journal of hypertension

authors： Ruddy MC,Arora A,Malka ES,Bialy GB

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS:In...

journal_title：American journal of hypertension

authors： Goharian TS,Goetze JP,Faber J,Andersen LB,Grøntved A,Jeppesen JL

更新日期：2017-06-01 00:00:00

abstract：:Three hundred eight outpatients referred for hypertension were studied. A continuous beat-to-beat noninvasive recording (Finapres) of blood pressure evaluated the blood pressure increase (9 mm Hg systolic and 4 mm Hg diastolic) induced by office sphygmomanometry. Thereafter, patients underwent a 24-h ambulatory blood ...

journal_title：American journal of hypertension

authors： Musso NR,Giacchè M,Galbariggi G,Vergassola C

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Uncontrolled treatment-resistant hypertension (TRH), i.e., blood pressure (BP, mm Hg) ≥140/≥90mm Hg in and out of office on ≥3 different BP medications at optimal doses, is common and has a poor prognosis. Aldosterone antagonist (AA) and renin-guided therapy (RGT) are effective strategies for improving BP co...

journal_title：American journal of hypertension

authors： Egan BM,Laken MA,Sutherland SE,Qanungo S,Fleming DO,Cook AG,Hester WH,Jones KW,Jebaily GC,Valainis GT,Way CF,Wright MB,Davis RA

更新日期：2016-08-01 00:00:00

abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...

journal_title：American journal of hypertension

authors： Tsuda K,Tsuda S,Nishio I,Masuyama Y,Goldstein M

更新日期：1998-12-01 00:00:00