Antagonism of the renin-angiotensin system can counteract cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in the normal heart.

abstract：:The aim of the present study was to assess the efficacy and tolerability of a calcium antagonist/beta-blocker fixed combination tablet used as first-line antihypertesnive therapy in comparison with an angiotensin converting enzyme inhibitor and placebo. Patients with uncomplicated essential hypertension (diastolic blo...

journal_title：American journal of hypertension

authors： Waeber B,Detry JM,Dahlöf B,Puig JG,Gundersen T,Hosie J,Januszewicz W,Lindström CJ,Magometschnigg D,Safar M,Tanser P,Toutouzas P

更新日期：1999-09-01 00:00:00

abstract：:To determine if a remodeling of the collagen matrix would occur in the absence of hypertrophy and cell necrosis and if such a remodeling could alter active and passive stiffness of the intact myocardium, five rats with genetic hypertension (SHR) were treated (SHRT) with hydralazine for 32 weeks, beginning at four week...

journal_title：American journal of hypertension

authors： Narayan S,Janicki JS,Shroff SG,Pick R,Weber KT

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The optimal schedule for self-monitoring home BP (SMHBP) readings is enormously important in the diagnosis of different phenotypes related to hypertension. The aim of this study was to determine the prognostic capacity of a 3-day SMHBP schedule when using or suppressing the first-day measurements in compilin...

journal_title：American journal of hypertension

authors： Bayó J,Dalfó A,Barceló MA,Saez M,Roca C,Pallozzi J,Coll-De-Tuero G

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Home blood pressure measurement (HBPM) is recommended by hypertension guidelines, particularly in the elderly. However, feasibility of HBPM in this age group has not been fully established. Our objective was therefore to assess HBPM feasibility in elderly individuals of the general population. METHODS:After...

journal_title：American journal of hypertension

authors： Cacciolati C,Tzourio C,Dufouil C,Alpérovitch A,Hanon O

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Obese and overweight patients are at increased risk of arterial stiffness, and visceral, epicardial and hepatic fat accumulation is associated with cardiovascular disease risk. In general, muscular lipids are stored either in interstitial adipose tissue (extramyocellular lipid (EMCL)) or in lipid droplets wi...

journal_title：American journal of hypertension

authors： Hasegawa N,Kurihara T,Sato K,Homma T,Fujie S,Fujita S,Sanada K,Hamaoka T,Iemitsu M

更新日期：2015-12-01 00:00:00

abstract：:Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR an...

journal_title：American journal of hypertension

authors： Ader JL,Tran-Van T,Praddaude F

更新日期：1988-07-01 00:00:00

abstract：:We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activatio...

journal_title：American journal of hypertension

authors： Xiao J,Pang PK

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Considering sex differences, salt sensitivity, and insulin resistance (IR), the effect of sodium restriction and increased potassium intake on blood pressure remains unclear in normotensive Asian individuals, compared to that in hypertensive patients. METHODS:To assess the influence of sodium and potassium ...

journal_title：American journal of hypertension

authors： Murao S,Takata Y,Yasuda M,Osawa H,Kohi F

更新日期：2018-07-16 00:00:00

abstract：:The aim of this study was to assess the macrostructure of the kidney and the grade of heterogeneity in renal cortical circulation in the early stages of essential hypertension. The subjects consisted of 84 patients (<50 years old) who underwent dynamic computed tomography (CT) because of various abdominal diseases and...

journal_title：American journal of hypertension

authors： Kojima S,Shida M,Tanaka K,Takano H,Yokoyama H,Kuramochi M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

journal_title：American journal of hypertension

authors： Sankaralingam S,Desai KM,Wilson TW

更新日期：2006-11-01 00:00:00

abstract：:The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensity of these disorders to manifest depression has not been reported. In this study, the LH behavio...

journal_title：American journal of hypertension

authors： Edwards E,King JA,Fray J

更新日期：2000-06-01 00:00:00

abstract：:We studied how closely changes in electronically monitored physical activity are reflected in changes in blood pressure and heart rate in a group of untreated hypertensive subjects. Thirty-nine hypertensive patients (office blood pressure > 140/ 90 mm Hg) of mean age 57 +/- 10 years (mean +/-SD) wore an ambulatory blo...

journal_title：American journal of hypertension

authors： Mansoor GA,White WB,McCabe EJ,Giacco S

更新日期：2000-03-01 00:00:00

abstract：:Among the major mechanisms controlling the renal release of renin, renal nerves are known to exert a direct stimulating action on juxtaglomerular cells that is mediated by beta-adrenoceptors. Activation of the renal nerves also exerts an important permissive role in order to amplify and possibly accelerate responses t...

journal_title：American journal of hypertension

authors： Stella A,Golin R,Zanchetti A

更新日期：1989-02-01 00:00:00

abstract：:The hypothesis that elevated Ca2+ intake lowers blood pressure in the spontaneously hypertensive rat (SHR) by altering intrinsic contractile properties of vascular smooth muscle was tested. The effect of 0.5, 1, and 2% Ca2+ in the diet on systolic blood pressure, serum-ionized Ca2+, and contractile properties of mesen...

journal_title：American journal of hypertension

authors： Bukoski RD,Xue H,McCarron DA

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:The "nondipping" pattern (NDP) of blood pressure, characterized by the absence of the reduction in blood pressure (BP) that typically takes place during the night time, has been associated with elevated cardiovascular morbidity, including stroke, myocardial infarction, and sudden cardiac-related death. In va...

journal_title：American journal of hypertension

authors： Myredal A,Friberg P,Johansson M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:It is not clear which educational strategy is most effective in helping patients to change their lifestyles. This study compared the efficacy of two different educational models on reducing blood pressure (BP). METHODS:This was a randomized controlled trial in ambulatory hypertensive patients >65 years of a...

journal_title：American journal of hypertension

authors： Figar S,Galarza C,Petrlik E,Hornstein L,Rodríguez Loria G,Waisman G,Rada M,Soriano ER,de Quirós FG

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:A successful weight loss program is essential treatment for obesity-related diseases, but it is well known that the majority of individuals do not succeed in weight loss maintenance. The present study evaluates hormonal mechanisms and the relationship of beta2-adrenoceptor polymorphisms involved in individua...

journal_title：American journal of hypertension

authors： Masuo K,Katsuya T,Kawaguchi H,Fu Y,Rakugi H,Ogihara T,Tuck ML

更新日期：2005-11-01 00:00:00

abstract：:The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...

journal_title：American journal of hypertension

authors： Fallo F,Sonino N,Barzon L,Pistorello M,Pagotto U,Paoletta A,Boscaro M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

journal_title：American journal of hypertension

authors： de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. METHODS:We studied healthy untreated patients with obstructive sleep apnea (18 se...

journal_title：American journal of hypertension

authors： Winnicki M,Shamsuzzaman A,Lanfranchi P,Accurso V,Olson E,Davison D,Somers VK

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:This study investigated the relationship of ethnicity to the differences between blood pressure (BP) measured in a clinic setting and by ambulatory blood pressure monitoring (ABPM) in individuals with a previous diagnosis of hypertension (HT) and without a previous diagnosis of hypertension (NHT). METHODS:A...

journal_title：American journal of hypertension

authors： Martin U,Haque MS,Wood S,Greenfield SM,Gill PS,Mant J,Mohammed MA,Heer G,Johal A,Kaur R,Schwartz C,McManus RJ

更新日期：2015-06-01 00:00:00

abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

journal_title：American journal of hypertension

authors： Falkner B,Hulman S,Kushner H

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association betwee...

journal_title：American journal of hypertension

authors： Hintsala HE,Kiviniemi AM,Antikainen R,Mäntysaari M,Jokelainen J,Hassi J,Tulppo MP,Herzig KH,Keinänen-Kiukaanniemi S,Rintamäki H,Jaakkola JJK,Ikäheimo TM

更新日期：2019-05-09 00:00:00

abstract：:The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

journal_title：American journal of hypertension

authors： Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

更新日期：2001-11-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...

journal_title：American journal of hypertension

authors： Schifter S,Krusell LR,Sehested J

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:The dopaminergic and endothelin systems, by regulating sodium transport in the renal proximal tubule (RPT), participate in the control of blood pressure. The D(3) and ETB receptors are expressed in RPTs, and D(3) receptor function in RPTs is impaired in spontaneously hypertensive rats (SHRs). Therefore, we t...

journal_title：American journal of hypertension

authors： Yu C,Yang Z,Ren H,Zhang Y,Han Y,He D,Lu Q,Wang X,Wang X,Yang C,Asico LD,Hopfer U,Eisner GM,Jose PA,Zeng C

更新日期：2009-08-01 00:00:00

abstract：:Previous work in this laboratory has shown that supplemental dietary calcium using milk as the source can lower blood pressure and serum cholesterol levels. Attempting to circumvent lactose intolerance, a 6-month crossover study of blood pressure and serum lipids in 50 free-living volunteers was done comparing 1,150 m...

journal_title：American journal of hypertension

authors： Bierenbaum ML,Wolf E,Bisgeier G,Maginnis WP

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Liddle's syndrome (LS) is a monogenic form of hypertension simulating a mineralocorticoid excess, and is currently suspected in young hypokalemic hypertensives. The aims of the study were: (i) to evaluate the clinical phenotype of LS in a newly identified Italian family of Sicilian origin carrying a gain-of-...

journal_title：American journal of hypertension

authors： Rossi E,Farnetti E,Nicoli D,Sazzini M,Perazzoli F,Regolisti G,Grasselli C,Santi R,Negro A,Mazzeo V,Mantero F,Luiselli D,Casali B

更新日期：2011-08-01 00:00:00

abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

journal_title：American journal of hypertension

authors： Cohn JN

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

journal_title：American journal of hypertension

authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

更新日期：2011-03-01 00:00:00