Abstract：
:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (BH, BP > 135/85 mm Hg). Plasma insulin concentration was measured during an oral glucose tolerance test (OGTT) in all subjects. In 50 cases, insulin clamps were performed. Plasma estradiol and free testosterone were analyzed in a subsample (n = 15) of women. Data were analyzed for BP and gender groups by two-way ANOVA. Compared to men, women in each BP group had higher plasma insulin: glucose ratios (P < .01) and sums of insulin on OGTT (P < .02). The insulin clamp data also demonstrated significantly lower insulin-stimulated glucose utilization (M) in women compared to men in each BP group (N males 7.28 +/- 0.72 v N females 4.94 +/- 1.2 mg/kg-min; BH males 5.28 +/- .56 v BH females 2.59 +/- 0.50 mg/kg-min; P < .004 for gender differences). Analysis of the sex hormone data found a significant correlation in the ratio of free testosterone/estradiol (T/E) with plasma glucose, insulin, insulin/glucose, and systolic BP (P < .05), and no correlation of T/E with body mass index or triceps skinfold thickness. These data indicate that there are significant gender differences in plasma insulin levels and in insulin sensitivity in African-Americans. The relationship of plasma insulin to sex hormones suggests that in females, hyperinsulinemia cosegregates with increased androgenicity.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Falkner B,Hulman S,Kushner Hdoi
10.1093/ajh/7.11.948subject
Has Abstractpub_date
1994-11-01 00:00:00pages
948-52issue
11eissn
0895-7061issn
1941-7225pii
0895-7061(94)90131-7journal_volume
7pub_type
杂志文章abstract：BACKGROUND:Adiposity measures are associated with increased pediatric blood pressure (BP). However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for h...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.82
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hps064
更新日期：2013-03-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/4.7.565
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Left atrial (LA) dilatation is associated with unfavorable outcome in hypertension. However, there are few data on clinical, demographic, and echocardiographic findings correlated with LA dilatation development. METHODS:From the Campania-Salute Network registry, we identified 5,375 hypertensive patients (52...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw043
更新日期：2016-09-01 00:00:00
abstract：:Increased dietary K+ increases plasma [K+] and is linked to or associated with reduced mortality from stroke and reduced blood pressure in humans and animals. We hypothesized that physiologic increases in extracellular [K+] ([K]o) directly inhibit cultured vascular smooth muscle cell (VSMC) proliferation. Studies were...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.4.346
更新日期：1994-04-01 00:00:00
abstract：:In this study, 395 healthy children had blood pressure and heart rate measured both at rest and during a stressful video game. Identical measurement procedures were used for three annual examinations. Consistently, black children demonstrated significantly greater pressor responses than white children. In view of the ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/4.7.630
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:There are no comprehensive guidelines on management of hypertensive emergency (HTNE) and complications. Despite advances in antihypertensive medications HTNE is accompanied with significant morbidity and mortality. METHODS:We queried the 2002-2012 nationwide inpatient sample database to identify patients wi...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx048
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Sympathetic activation occurs in hypertension (HT) and after acute myocardial infarction (AMI) and is related to greater cardiovascular risk. Also, AMI in patients with HT (AMI-HT) carries greater risk than that in normal subjects (AMI-NT). We therefore planned to determine whether the sympathetic activation...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.03.015
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. METHODS:Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.262
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.23
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpv121
更新日期：2016-03-01 00:00:00
abstract：:We assessed the efficacy of monotherapy with trandolapril, an angiotensin converting enzyme (ACE) inhibitor, and of verapamil slow-release (SR), a calcium antagonist, each in a range of three doses as monotherapy, and in the nine possible combinations of therapy in patients with stage I to III diastolic hypertension. ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(97)00102-7
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/ajh.2007.81
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. However, the association between serum vitamin D and blood pressure in pregnant women has been scarcely evaluated, particularly in women with a high risk of developing hypertensive disorders of pregnancy. We sought ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu043
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. METHODS:We examined the effect of dietary salt restriction on PAI-1 levels in 239 hyperte...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1016/s0895-7061(02)02952-7
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Although previous studies have explored the effect of smoking on blood pressure, little is still known about the role of time to first cigarette (TTFC)-an indicator of nicotine dependence-in hypertension. Therefore, we evaluated this association using representative nationwide data. METHODS:Current daily sm...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy170
更新日期：2019-01-15 00:00:00
abstract：:Alterations in Na, K ATPase pump activity as well as erythrocyte (RBC) intracellular sodium concentration (Nai) have been demonstrated in humans and rats with established hypertension. The contribution of hypertension itself to these changes is unclear. Accordingly, we investigated RBC ion transport and plasma ouabain...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.8.604
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:In patients free from overt cardiac disease, R wave in aVL lead (RaVL) is strongly correlated with left ventricular mass index (LVMI) assessed by transthoracic echocardiography. The aim of the present study was to extend this finding to other settings (cardiomyopathy or conduction disorders), by comparing EC...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu268
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:On the basis of evidence of plasma leptin (LE) effects on cardiovascular system, we assessed possible association of LE and Doppler-derived left ventricular (LV) diastolic function in arterial hypertension. METHODS:Doppler echocardiography, blood sample for fasting plasma LE levels, and euglycemic hyperinsu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02137-9
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:This study examines the interrelationship between gestational weight gain, pre-pregnancy body mass index (BMI), race/ethnicity, and their association with hypertensive disorders during pregnancy (HDP). METHODS:Data from the 2004-2011 national Pregnancy Risk Assessment Monitoring System (PRAMS) were analyzed...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpv184
更新日期：2016-06-01 00:00:00
abstract：:The objective of this study was to test the relationship between neurologic and microvascular complications of type 1 diabetes mellitus. It was hypothesized that the mechanisms operative in autonomic dysfunction seen in diabetic patients with microangiopathy play a role in the rapidity of progression to renal failure....
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00472-x
更新日期：1998-03-01 00:00:00
abstract：:Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(97)00422-6
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Coffee is a rich source of antioxidative polyphenols, but epidemiological studies and interventional trials have failed to demonstrate any clear beneficial effects of coffee consumption on hypertension. The interaction between hydroxyhydroquinone (HHQ) and 5-caffeoylquinic acid (CQA) was examined, in an atte...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2007.3
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Blood pressure (BP) response to the cold pressor test (CPT) has been associated with increased risk of cardiovascular disease. We studied risk factors associated with BP response to CPT. METHODS:We conducted the CPT among 2,682 individuals in rural north China. BP was measured using a standard mercury sphyg...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt075
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodel...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.06.016
更新日期：2004-11-01 00:00:00
abstract：:The influence of increased lability of blood pressure on the development of aortic atherosclerosis was examined. Because sinoaortic denervation (SAD) produced increased lability of blood pressure without blood pressure elevation, the development of atheromatous plaque was examined in SAD rats. These rats were fed a hi...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.5.453
更新日期：1994-05-01 00:00:00
abstract：:Three hundred eight outpatients referred for hypertension were studied. A continuous beat-to-beat noninvasive recording (Finapres) of blood pressure evaluated the blood pressure increase (9 mm Hg systolic and 4 mm Hg diastolic) induced by office sphygmomanometry. Thereafter, patients underwent a 24-h ambulatory blood ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00354-1
更新日期：1996-04-01 00:00:00
abstract：:It is likely that a number of independent heritable traits, each encoded by a singular gene, contribute to pathologic elevations in blood pressure in humans. Genetic polymorphisms of individual genes may result in intermediate phenotypes which, by themselves, do not raise blood pressure, but, coupled with environmenta...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00155-I
更新日期：1995-09-01 00:00:00
abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02074-x
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:The polymorphism of several candidate genes has been studied in relation to essential hypertension and cardiovascular complications. Target organ damage in essential hypertension is a complex disorder influenced by multiple genetic and environmental factors. The possible contribution of endothelin gene varia...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02162-8
更新日期：2001-08-01 00:00:00
