Abstract：
BACKGROUND:Vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. However, the association between serum vitamin D and blood pressure in pregnant women has been scarcely evaluated, particularly in women with a high risk of developing hypertensive disorders of pregnancy. We sought to evaluate the association between serum 25-hydroxyvitamin D and blood pressure in pregnant women with gestational diabetes mellitus (GDM). METHODS:A cohort of 184 pregnant women with GDM was followed during the third trimester of pregnancy and early puerperium. Blood pressure was recorded in all prenatal visits, and serum vitamin D was measured by chemiluminescence immunoassay. Pearson's coefficients and multiple linear regressions were used to study predictors of blood pressure levels. RESULTS:Women with vitamin D insufficiency (<30ng/mL; n = 159) had higher systolic and diastolic blood pressure than the remaining participants. In white women (n = 136), serum vitamin D levels presented a significant negative correlation with systolic blood pressure at the beginning (r = -0.268; P = 0.002) and at the end of the third trimester (r = -0.203; P = 0.02), and vitamin D significantly affected systolic blood pressure after adjusting for confounders. This was not observed in women of other ethnicities. CONCLUSIONS:In this cohort of pregnant women with GDM, vitamin D insufficiency was associated with higher blood pressure, and in white women, serum vitamin D was an independent predictor of systolic blood pressure during pregnancy.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Weinert LS,Reichelt AJ,Schmitt LR,Boff R,Oppermann ML,Camargo JL,Silveiro SPdoi
10.1093/ajh/hpu043subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1316-20issue
10eissn
0895-7061issn
1941-7225pii
hpu043journal_volume
27pub_type
杂志文章abstract：:This double-blind placebo controlled study investigated the antihypertensive and humoral effects of nifedipine capsules in patients with essential hypertension inadequately controlled (seated diastolic blood pressure greater than or equal to 95 mm Hg) by hydrochlorothiazide (HCTZ) alone. Nifedipine acutely (first dose...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/2.11.828
更新日期：1989-11-01 00:00:00
abstract：:Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(00)00262-4
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Clonidine, a centrally acting antihypertensive agent, has been used successfully in pregnancy. We sought to describe the pharmacodynamic effects of clonidine in pregnancy and the associated impact on fetal growth. METHODS:A retrospective cohort study was performed. Maternal hemodynamics were measured before...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.159
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Although the acute increase of arterial stiffness and blood pressure (BP) after cigarette smoking in healthy smokers is considered a possible mechanism of increased cardiovascular risk, the acute effect of smoking on arterial stiffness in hypertensive smokers is unknown. We investigated the acute effects of ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.12.017
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Insulin resistance has been related to elevated blood pressure (BP) in obese children and may adversely affect the vasculature by arterial stiffening. The objective was to investigate whether daytime and nighttime BP were elevated and related to insulin resistance and arterial stiffness in obese children and...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu055
更新日期：2014-11-01 00:00:00
abstract：:Compliance is commonly defined as the extent to which a person's behavior coincides with medical or health advice. There is evidence that noncompliance is a common problem with many medications, including antihypertensive treatment. Since noncompliance can have serious adverse effects on patient health it is important...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/0895-7061(95)00195-6
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:Anthropometric measurements and indexes that assess excess of adiposity are associated with cardiovascular risk factors, and predict diabetes mellitus. METHODS:This cross-sectional study reported the performance of adiposity indexes to detect or turn diabetes unlikely in patients with hypertension. Patients...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.212
更新日期：2011-02-01 00:00:00
abstract：:Insulin resistance, the most important factor in metabolic syndrome X, has been considered to raise blood pressure. Recently it was reported that insulin resistance was related to an elevated plasma level of leptin, which is an adipocyte-specific ob gene product and which plays a role in food intake suppression, therm...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00310-5
更新日期：1997-10-01 00:00:00
abstract：:The benzothiazepine calcium channel antagonist diltiazem is a short-acting drug. To achieve effective 24-h blood pressure control with once-daily dosing, it relies on various extended drug-delivery systems that have grown in importance as a result of the recent reports relating the use of short-acting calcium channel ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(99)00097-7
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ). METHODS:This was a randomized, double-blind,...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.amjhyper.2003.11.003
更新日期：2004-03-01 00:00:00
abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00119-3
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy111
更新日期：2018-10-15 00:00:00
abstract：BACKGROUND:The efficacy and safety of angiotensin receptor blockers (ARBs) in the older population is unclear. OBJECTIVES:To determine the efficacy and safety of ARBs in older patients. METHODS:Randomized trials that compared ARBs to control and reported clinical outcomes in patients with a mean age of 65 years or ol...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析,评审
doi：10.1093/ajh/hpu209
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Central aortic blood pressure (CBP) and CBP-derived parameters are independent predictors of cardiovascular risk. Angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors plus calcium channel blockers are the recommended first-line treatments in hypertensive diabetic patients; howe...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1093/ajh/hpw033
更新日期：2016-09-01 00:00:00
abstract：:This study was undertaken to characterize blood pressure (by continuous blood pressure recording), renal hemodynamics, and excretory function in high-fructose-fed insulin-resistant dogs. We fed 10 mongrel dogs for 28 days with a normal sodium diet containing 60% of the calories either as fructose (n = 6) or dextrose (...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00118-9
更新日期：1995-07-01 00:00:00
abstract：:We assessed the efficacy of monotherapy with trandolapril, an angiotensin converting enzyme (ACE) inhibitor, and of verapamil slow-release (SR), a calcium antagonist, each in a range of three doses as monotherapy, and in the nine possible combinations of therapy in patients with stage I to III diastolic hypertension. ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(97)00102-7
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The aim of our study was to investigate the control of hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We retrospectively reviewed all ABPM studies in our center. Controlled HT was defined as systolic and diastolic BP index (patients' BP divided by the 9...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.218
更新日期：2012-03-01 00:00:00
abstract：:It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms. Consequently, an increased concentration of calcium in renal circulation may in...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/4.7.473s
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2009.115
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHOD...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2009.263
更新日期：2010-04-01 00:00:00
abstract：:Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...
journal_title：American journal of hypertension
pub_type： 历史文章,杂志文章
doi：10.1016/s0895-7061(99)00212-5
更新日期：2000-04-01 00:00:00
abstract：:In normal coronary arteries, increased flow velocity induces endothelium-dependent dilation, and dilation in response to sympathetic stimulation evoked by the cold pressor test is partly due to increased flow velocity. In arterial hypertension, angiographically normal coronary arteries were constricted by acetylcholin...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00028-n
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:As hypertension, obesity, and leanness are reported to be associated with poor cognitive function, it is possible that obesity or leanness in hypertensive patients may also be associated strongly with poor cognitive function. METHODS:We recruited 184 elderly hypertensive patients comprising 93 very elderly ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2008.157
更新日期：2008-06-01 00:00:00
abstract：:The objective of this study was to evaluate whether the major histocompatibility complex of the rat can be related to blood pressure (BP) level and BP response to stress. Blood pressure was determined under light ether anesthesia or during moderate restraint stress in normotensive Lewis rats, in rat strains congenic w...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(96)00023-4
更新日期：1996-07-01 00:00:00
abstract：:Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1038/ajh.2008.258
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.09.005
更新日期：2006-03-01 00:00:00
abstract：:To assess whether aerobic exercise training is an effective and an alternative method to control blood pressure (BP) in hypertension, 32 uncomplicated, never treated patients suffering from mild-to-moderate essential arterial hypertension (EAH) were included in an aerobic exercise training program using a regular stan...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00265-4
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1093/ajh/hpt293
更新日期：2014-07-01 00:00:00
abstract：:It is premature to state that ambulatory blood pressure (ABP) values below a given level should be considered normal, and those above it abnormal, in terms of prognostic implications on cardiovascular (CV) morbidity. We do not know whether CV morbidity in hypertensive subjects with apparently normal ABP (white coat hy...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
abstract：:The effects of increased dietary calcium intake on blood pressure and arterial function were investigated in one-kidney deoxycorticosterone-salt hypertensive Wistar rats. The calcium content of the control diet was 1.1%, and that of the high calcium diet, 2.5%. During the 10-week study calcium supplementation markedly...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.6.520
更新日期：1994-06-01 00:00:00
