Association of body mass index with cognitive function in elderly hypertensive Japanese.

Abstract:

BACKGROUND:As hypertension, obesity, and leanness are reported to be associated with poor cognitive function, it is possible that obesity or leanness in hypertensive patients may also be associated strongly with poor cognitive function. METHODS:We recruited 184 elderly hypertensive patients comprising 93 very elderly (aged >or=80 years) and 91 younger elderly (aged 61-79 years) subjects. A mini-mental state examination (MMSE) and 24-h ambulatory blood pressure monitoring (ABPM) were performed in all participants. Patients were classified as either lean, normal physique, or obese according to the body mass index (BMI) quartile. The prevalence of poor cognitive function, total MMSE score, and MMSE subscores were compared between the groups. RESULTS:The prevalence of poor cognitive function, total MMSE score, and MMSE subscore attention/calculation were significantly different between the groups both in the total study population and in the very elderly patients. The multiple logistic regression model showed that leanness was a significant determinant of poor cognitive function in both the total study population (odds ratio (OR) 2.54, 95% confidence interval (CI) 1.13-5.73, P = 0.02) and the very elderly patients (OR 3.94, 95% CI 1.31-11.82, P = 0.01). Obesity was not a significant determinant in either the total study population, very elderly, or younger elderly groups. CONCLUSION:While obesity in hypertensive elderly patients was not associated with poor cognitive function, leanness in hypertensive elderly patients was, especially in the very elderly.

journal_name

Am J Hypertens

authors

Sakakura K,Hoshide S,Ishikawa J,Momomura S,Kawakami M,Shimada K,Kario K

doi

10.1038/ajh.2008.157

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

627-32

issue

6

eissn

0895-7061

issn

1941-7225

pii

ajh2008157

journal_volume

21

pub_type

杂志文章
  • Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives.

    abstract:BACKGROUND:In hypertensives, nondippers are more likely than dippers to suffer silent, as well as overt, hypertensive target organ damage. In this study, we investigated whether a nondipper status was associated with target organ damage in normotensives. METHODS:We performed ambulatory blood pressure (BP) monitoring, ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(03)00567-3

    authors: Hoshide S,Kario K,Hoshide Y,Umeda Y,Hashimoto T,Kunii O,Ojima T,Shimada K

    更新日期:2003-06-01 00:00:00

  • Circadian blood pressure overswinging in a physically fit, normotensive African American woman.

    abstract::Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian B...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02973-4

    authors: Borer KT,Cornelissen G,Halberg F,Brook R,Rajagopalan S,Fay W

    更新日期:2002-09-01 00:00:00

  • Comparative Study of the Efficacy of Olmesartan/Amlodipine vs. Perindopril/Amlodipine in Peripheral and Central Blood Pressure Parameters After Missed Dose in Type 2 Diabetes.

    abstract:BACKGROUND:Central aortic blood pressure (CBP) and CBP-derived parameters are independent predictors of cardiovascular risk. Angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors plus calcium channel blockers are the recommended first-line treatments in hypertensive diabetic patients; howe...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ajh/hpw033

    authors: Redon J,Pichler G,Missed Dose Study Group.

    更新日期:2016-09-01 00:00:00

  • Metabolic syndrome and insulin resistance in the TROPHY sub-study: contrasting views in patients with high-normal blood pressure.

    abstract:BACKGROUND:Although insulin resistance and metabolic syndrome are often used synonymously, concordance is not established. METHODS:Metabolic, hemodynamic, and hormonal data were analyzed on 141 patients in the Trial of Preventing Hypertension (TROPHY) Sub-Study with high-normal blood pressure (BP) (130 to 139/85 to 89...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2004.08.008

    authors: Egan BM,Papademetriou V,Wofford M,Calhoun D,Fernandes J,Riehle JE,Nesbitt S,Michelson E,Julius S,TROPHY Sub-study Investigative Team.

    更新日期:2005-01-01 00:00:00

  • Nocturnal hypertension or nondipping: which is better associated with the cardiovascular risk profile?

    abstract:BACKGROUND:Both increased night blood pressure (BP) and nondipping are associated with worse cardiovascular risk and prognosis. However, as they are often related features, their relative importance has been difficult to assess separately. In this study we address separate associations of nocturnal hypertension and non...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt175

    authors: de la Sierra A,Gorostidi M,Banegas JR,Segura J,de la Cruz JJ,Ruilope LM

    更新日期:2014-05-01 00:00:00

  • Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.

    abstract::Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-D...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/S0895-7061(96)00254-3

    authors: Keen HL,Brands MW,Alonso-Galicia M,Hall JE

    更新日期:1996-12-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.106s

    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is commonly associated with cardiac hypertrophy, reduced Ca²(+) uptake into the sarcoplasmic reticulum (SR) and impaired myocardial relaxation. Treatment to prevent MI-associated complications is currently lacking. The purpose of the present study was to investigate the remodeling ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.157

    authors: Costa DG,da Silva JS,Kümmerle AE,Sudo RT,Landgraf SS,Caruso-Neves C,Fraga CA,de Lacerda Barreiro EJ,Zapata-Sudo G

    更新日期:2010-11-01 00:00:00

  • Ambulatory--not office--blood pressures decline during hormone replacement therapy in healthy postmenopausal women.

    abstract::Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean ag...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(98)00165-4

    authors: van Ittersum FJ,van Baal WM,Kenemans P,Mijatovic V,Donker AJ,van der Mooren MJ,Stehouwer CD

    更新日期:1998-10-01 00:00:00

  • I1 receptors, cardiovascular function, and metabolism.

    abstract::When injected into the medullary site of the hypotensive action of clonidine, imidazolines and related compounds decrease blood pressure (BP), whereas no phenylethylamine compounds were capable of producing such an effect at the same site. There is much biochemical and pharmacologic evidence to support the involvement...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(01)02238-5

    authors: Bousquet P

    更新日期:2001-11-01 00:00:00

  • Central serotonergic mechanisms in hypertension.

    abstract::Serotonin-containing neurons in the central nervous system are grouped into a number of discrete and distinctive collections with cell bodies in the brainstem and projections passing to many regions of the brain and spinal cord. Evidence is presented that activation of one projection of serotonin-containing neurons fr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/1.1.79

    authors: Chalmers JP,Pilowsky PM,Minson JB,Kapoor V,Mills E,West MJ

    更新日期:1988-01-01 00:00:00

  • Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus.

    abstract:BACKGROUND:Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajh/hpw146

    authors: Sardana M,Vasim I,Varakantam S,Kewan U,Tariq A,Koppula MR,Syed AA,Beraun M,Drummen NE,Vermeer C,Akers SR,Chirinos JA

    更新日期:2017-02-01 00:00:00

  • Metabolic Syndrome and Cardiovascular Risk in Elderly Treated Hypertensive Patients.

    abstract:BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv121

    authors: Pierdomenico SD,Pierdomenico AM,Di Tommaso R,Coccina F,Di Carlo S,Cuccurullo F,Porreca E

    更新日期:2016-03-01 00:00:00

  • Patient Barriers and Facilitators to Ambulatory and Home Blood Pressure Monitoring: A Qualitative Study.

    abstract:BACKGROUND:Guidelines recommend that patients with newly elevated office blood pressure undergo ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM) to rule-out white coat hypertension before being diagnosed with hypertension. We explored patients' perspectives of the barriers and facili...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpy062

    authors: Carter EJ,Moise N,Alcántara C,Sullivan AM,Kronish IM

    更新日期:2018-07-16 00:00:00

  • Blood pressure and the risk of stroke, cardiovascular disease, and all-cause mortality among Japanese: the JPHC Study.

    abstract:BACKGROUND:Little is known about the influence of blood pressure (BP) on cardiovascular disease (CVD) outcomes among Asian populations. METHODS:We examined population attributable fractions (PAFs) and hazard ratios (HRs) associated with BP in relation to stroke and coronary heart disease (CHD) incident and mortality w...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.356

    authors: Ikeda A,Iso H,Yamagishi K,Inoue M,Tsugane S

    更新日期:2009-03-01 00:00:00

  • Angiotensin-converting enzyme inhibitors. Emerging differences and new compounds.

    abstract::Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/2.1.57

    authors: Kostis JB

    更新日期:1989-01-01 00:00:00

  • Blood pressure and cognitive functioning among independent elderly.

    abstract:BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(03)01005-7

    authors: Paran E,Anson O,Reuveni H

    更新日期:2003-10-01 00:00:00

  • History of antihypertensive therapy influences the relationships of alcohol with blood pressure and pulse pressure in older men.

    abstract:BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.52

    authors: Wakabayashi I

    更新日期:2010-06-01 00:00:00

  • Altering therapy of type II diabetes mellitus from insulin to tolazamide increases blood pressure in spite of weight loss.

    abstract::In a retrospective study we investigated the effects of altering treatment of type II diabetes mellitus from insulin to tolazamide on weight and blood pressure. In 17 patients, weight decreased from 136 +/- 6 to 131 +/- 6% of ideal body weight (P = .01). Even though weight loss occurred, mean systolic blood pressure i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00046-R

    authors: Schmitt JK,Johns SB

    更新日期:1995-05-01 00:00:00

  • National prevalence and associated risk factors of hypertension and prehypertension among Vietnamese adults.

    abstract:BACKGROUND:Hypertension has recently been identified as the leading risk factor for global mortality. This study aims to present the national prevalence of hypertension and prehypertension and, their determinants in Vietnamese adults. METHODS:Nationally representative data were obtained from the National Adult Overwei...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu092

    authors: Do HT,Geleijnse JM,Le MB,Kok FJ,Feskens EJ

    更新日期:2015-01-01 00:00:00

  • Methods and devices for measuring arterial compliance in humans.

    abstract::This review analyses methods and devices used worldwide to evaluate the arterial stiffness. Three main methodologies are based upon analysis of pulse transit time, of wave contour of the arterial pulse, and of direct measurement of arterial geometry and pressure, corresponding to regional, systemic and local determina...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(02)02962-x

    authors: Pannier BM,Avolio AP,Hoeks A,Mancia G,Takazawa K

    更新日期:2002-08-01 00:00:00

  • Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.

    abstract:BACKGROUND:We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older hypertensive patients. We simultaneously evaluated other biomarkers, such as high-molecular-weight (HMW) adiponectin, high-sensitivit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt232

    authors: Yano Y,Nakazato M,Toshinai K,Inokuchi T,Matsuda S,Hidaka T,Hayakawa M,Kangawa K,Shimada K,Kario K

    更新日期:2014-05-01 00:00:00

  • Characterization of a Na+/K+-ATPase inhibitor from human plasma: preliminary data.

    abstract::The role of an endogenous sodium pump inhibitor in the pathogenesis of hypertension has been reported in several papers. Unfortunately, because of the unknown structure and lack of biochemical characterization, some discrepancies have arisen. In this study we report a method to obtain extracts from human plasma that a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.56s

    authors: Boschi S,Munarini A,Borghi C,Strocchi E,Costa FV,Mussi A,Ettore A

    更新日期:1988-07-01 00:00:00

  • Cytosolic Ca2+ regulation attenuates ANP-induced cGMP response in vascular smooth muscle cells of the SHR.

    abstract::Cultured vascular smooth muscle cells (VSMCs) of the spontaneously hypertensive rat (SHR) show a higher density (Bmax) of ANP receptors and a blunted cyclic (c) GMP response to the hormone. To explore the idea that a higher cytosolic free Ca2+ (Cai2+) may be responsible for a blunted cGMP response to ANP, we examined ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.2.111

    authors: Nakamura M,Nakamura A,Hatori N,Fine BP,Aviv A

    更新日期:1989-02-01 00:00:00

  • Effect of insulin on renal sodium and uric acid handling in essential hypertension.

    abstract::In normal subjects, insulin decreases the urinary excretion of sodium, potassium, and uric acid. We tested whether these renal effects of insulin are altered in insulin resistant hypertension. In 37 patients with essential hypertension, we measured the changes in urinary excretion of sodium, potassium, and uric acid i...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/0895-7061(96)00098-2

    authors: Muscelli E,Natali A,Bianchi S,Bigazzi R,Galvan AQ,Sironi AM,Frascerra S,Ciociaro D,Ferrannini E

    更新日期:1996-08-01 00:00:00

  • Birth measurements, family history, and environmental factors associated with later-life hypertensive status.

    abstract:BACKGROUND:This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. METHODS:Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.262

    authors: Chen X,Zhang ZX,George LK,Wang ZS,Fan ZJ,Xu T,Zhou XL,Han SM,Wen HB,Zeng Y

    更新日期:2012-04-01 00:00:00

  • Hypertension in young patients after renal transplantation: ambulatory blood pressure monitoring versus casual blood pressure.

    abstract::The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(97)00484-6

    authors: Calzolari A,Giordano U,Matteucci MC,Pastore E,Turchetta A,Rizzoni G,Alpert B

    更新日期:1998-04-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract::There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title:American journal of hypertension

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1093/ajh/4.12.747s

    authors: Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期:1991-12-01 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract::Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/2.8.650

    authors: Devereux RB

    更新日期:1989-08-01 00:00:00

  • Accuracy of anthropometric indexes of obesity to predict diabetes mellitus type 2 among men and women with hypertension.

    abstract:BACKGROUND:Anthropometric measurements and indexes that assess excess of adiposity are associated with cardiovascular risk factors, and predict diabetes mellitus. METHODS:This cross-sectional study reported the performance of adiposity indexes to detect or turn diabetes unlikely in patients with hypertension. Patients...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.212

    authors: Marcadenti A,Fuchs SC,Moreira LB,Wiehe M,Gus M,Fuchs FD

    更新日期:2011-02-01 00:00:00