当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.

Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.

Abstract：

:Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-Dawley rats (n = 16) were instrumented with artery and vein catheters and placed in metabolic cages. Propranolol and prazosin (10 mg/kg/day each) were infused continuously intravenously in 9 rats and 7 other rats received vehicle. Mean arterial pressure (MAP) and heart rate (HR) were measured 24 h per day using computerized methods. After a control period, a 7-day intravenous infusion of insulin (1.5 microU/kg/min) was begun and glucose was coadministered intravenously at 23 mg/kg/min to prevent hypoglycemia. The MAP averaged 93 +/- 1 mm Hg in the blockade rats during the control period, which was significantly lower than the 98 +/- 1 mm Hg in the normal rats. During insulin infusion, MAP increased similarly in both groups, with a 10 +/- 2 mm Hg and 11 +/- 1 mm Hg increase in normal and blockade rats, respectively, by day 7. The HR also increased in both groups: from 417 +/- 8 beats/ min to 426 +/- 13 beats/min (P = NS) in normal rats and from 379 +/- 10 beats/min to 419 +/- 10 beats/min (P < .05) in blockade rats. Control sodium excretion averaged 2.5 +/- 0.1 mEq/day in both groups and no significant change in sodium balance was measured in either group. All variables returned toward control after stopping insulin. These results suggest that increased adrenergic activity is not required for chronic hyperinsulinemia to raise blood pressure in rats.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Keen HL,Brands MW,Alonso-Galicia M,Hall JE

doi

10.1016/S0895-7061(96)00254-3

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1192-9

issue

12 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(96)00254-3

journal_volume

9

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • A cross-national comparative study of blood pressure and hypertension between English and Dutch South-Asian- and African-origin populations: the role of national context.

    abstract：BACKGROUND:We compare patterns of blood pressure (BP) and prevalence of hypertension between white-Dutch and their South-Asian and African minority groups with their corresponding white-English and their South-Asian and African ethnic minority groups; and the contribution of physical activity, body sizes, and socioecon...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ajh.2010.39

    authors： Agyemang C,Kunst A,Bhopal R,Zaninotto P,Unwin N,Nazroo J,Nicolaou M,Redekop WK,Stronks K

    更新日期：2010-06-01 00:00:00

  • Relationship of insulin resistance to macro- and microvasculature reactivity in hypertension.

    abstract：BACKGROUND:Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. The present study was conducted to clarify whether the IR is more closely related to the macrovasculature...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.3

    authors： Yoshida M,Tomiyama H,Yamada J,Matsumoto C,Odaira M,Shiina K,Yamashina A

    更新日期：2010-05-01 00:00:00

  • Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.

    abstract：:In essential hypertension (EHT) the presence of a metabolic syndrome increases the risk of cardiovascular disease. A cell membrane abnormality is implicated but its role in cardiovascular disease is unclear. Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinfl...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02136-7

    authors： Fardon NJ,Wilkinson R,Thomas TH

    更新日期：2001-09-01 00:00:00

  • Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.

    abstract：BACKGROUND:The aims of this study were to document the presence of phospholipase C (PLC) isozymes beta(1), gamma(1), and delta(1) in freshly isolated renal glomeruli and resistance vessels, to compare their expression and activity to that in aorta, and to contrast values between 6-week-old Wistar-Kyoto (WKY) controls a...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.06.009

    authors： Peng Z,Dang A,Arendshorst WJ

    更新日期：2007-01-01 00:00:00

  • Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats.

    abstract：BACKGROUND:Osteopontin (Opn) is highly upregulated in many different animal models of renal disease, where it is suspected to participate in progression of the disease. In some models, angiotensin II (Ang II) seems to induce the elevated Opn production. Therefore, we examined the regulation of Opn in two-kidney, one-cl...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)03266-1

    authors： Gauer S,Hartner A,Hauser IA,Fierlbeck W,Eberhardt W,Geiger H

    更新日期：2003-03-01 00:00:00

  • Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.

    abstract：BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa021

    authors： Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

    更新日期：2020-04-29 00:00:00

  • Sodium retention and volume expansion as mechanisms.

    abstract：:After nephrectomy, the level of arterial pressure is determined by the permitted degree of fluid volume expansion. With kidneys present, the fundamental requirement for fluid volume homeostasis is met by maintaining the balance between sodium and water intake and output. When one-kidney, one-clip (1-K,1-C) hypertensio...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/4.10.534s

    authors： Ledingham JM

    更新日期：1991-10-01 00:00:00

  • PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma.

    abstract：BACKGROUND:Parathyroid hormone (PTH) stimulates aldosterone secretion in human adrenocortex and is regulated by the renin-angiotensin-aldosterone system. We speculated that measurement of PTH may be a valuable aid in the diagnosis of aldosterone-producing adenoma (APA). METHODS:To test this hypothesis, we recruited 14...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv146

    authors： Zhang LX,Gu WJ,Li YJ,Wang Y,Wang WB,Wang AP,Shen L,Zang L,Yang GQ,Lu ZH,Dou JT,Mu YM

    更新日期：2016-05-01 00:00:00

  • Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency.

    abstract：BACKGROUND:Hypertension treatment is important in managing chronic renal insufficiency (CRI). Little is known, however, about the blood pressure (BP) control achieved or the pattern of antihypertensive drug prescription among CRI patients. METHODS:Using computerized medical records, we studied 3,089 adult hypertensive...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02202-6

    authors： Hsu CY,Bates DW,Kuperman GJ,Curhan GC

    更新日期：2001-12-01 00:00:00

  • Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension.

    abstract：BACKGROUND:Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension, but longitudinal studies are missing. METHODS:We performed an echocardiographic follow-up study in young initially normotensive male offspring of hypertensive (OHyp) (n = 25) and normotensive (ONorm) ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01245-0

    authors： Aeschbacher BC,Hutter D,Fuhrer J,Weidmann P,Delacrétaz E,Allemann Y

    更新日期：2001-02-01 00:00:00

  • Common genetic variations in the vitamin D pathway in relation to blood pressure.

    abstract：BACKGROUND:Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. METHODS:We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析

    doi：10.1093/ajh/hpu049

    authors： Wang L,Chu A,Buring JE,Ridker PM,Chasman DI,Sesso HD

    更新日期：2014-11-01 00:00:00

  • Determinants of exercise capacity in hypertensive patients: new insights from tissue Doppler echocardiography.

    abstract：BACKGROUND:Determinants of exercise capacity have not been clearly defined in hypertensive patients. Doppler tissue imaging (DTI), a recently developed echocardiographic modality, is useful for evaluating left ventricular (LV) function regardless of loading conditions. The present study was performed to identify the de...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(03)00842-2

    authors： Kim HK,Kim YJ,Cho YS,Sohn DW,Lee MM,Park YB,Choi YS

    更新日期：2003-07-01 00:00:00

  • Blood pressure control in the hypertension clinic.

    abstract：BACKGROUND:One effort to improve hypertension care in the United States is the development of the "Hypertension Specialist" program with appropriate training and certification of individual physicians. METHODS:We examined the impact of a hypertension clinic on blood pressure (BP) levels and control. RESULTS:By one ye...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(03)01030-6

    authors： Bansal N,Tendler BE,White WB,Mansoor GA

    更新日期：2003-10-01 00:00:00

  • Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases.

    abstract：:Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for reni...

    journal_title：American journal of hypertension

    pub_type：

    doi：10.1016/j.amjhyper.2005.11.014

    authors： Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

    更新日期：2006-05-01 00:00:00

  • Dietary calcium. A method of lowering blood pressure.

    abstract：:Previous work in this laboratory has shown that supplemental dietary calcium using milk as the source can lower blood pressure and serum cholesterol levels. Attempting to circumvent lactose intolerance, a 6-month crossover study of blood pressure and serum lipids in 50 free-living volunteers was done comparing 1,150 m...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.3.149s

    authors： Bierenbaum ML,Wolf E,Bisgeier G,Maginnis WP

    更新日期：1988-07-01 00:00:00

  • Factors That Predict the Development of Hypertension in Women With Pregnancy-Induced Hypertension.

    abstract：BACKGROUND:Pregnancy-induced hypertension (PIH) is associated with chronic hypertension (HTN) and cardiovascular complications. We investigated the factors that predict the development of chronic HTN in women with PIH. METHODS:The study population comprised 108 women with PIH and 87 healthy age-matched women control s...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv073

    authors： Shopen N,Schiff E,Koren-Morag N,Grossman E

    更新日期：2016-01-01 00:00:00

  • Accuracy of anthropometric indexes of obesity to predict diabetes mellitus type 2 among men and women with hypertension.

    abstract：BACKGROUND:Anthropometric measurements and indexes that assess excess of adiposity are associated with cardiovascular risk factors, and predict diabetes mellitus. METHODS:This cross-sectional study reported the performance of adiposity indexes to detect or turn diabetes unlikely in patients with hypertension. Patients...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.212

    authors： Marcadenti A,Fuchs SC,Moreira LB,Wiehe M,Gus M,Fuchs FD

    更新日期：2011-02-01 00:00:00

  • Endothelial dysfunction in resistance arteries is related to high blood pressure and circulating low density lipoproteins in previously treated hypertension.

    abstract：BACKGROUND:Peripheral endothelial dysfunction has been demonstrated in hypertension. However, its relationship to blood pressure (BP) load, vascular structure, and metabolic disturbances in patients with long-standing, previously treated hypertension is unclear. METHODS:A total of 41 patients with stage I to III essen...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02148-3

    authors： Olsen MH,Wachtell K,Aalkjaer C,Devereux RB,Dige-Petersen H,Ibsen H

    更新日期：2001-09-01 00:00:00

  • Sympathetic nervous control of blood pressure. Role in primary hypertension.

    abstract：:After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of bo...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.3.103s

    authors： Folkow B

    更新日期：1989-03-01 00:00:00

  • Does evidence-based medicine suggest that physicians should not be measuring blood pressure in the hypertensive patient?

    abstract：:The most common reason for an outpatient physician visit is for the diagnosis and treatment of hypertension. The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC) VII, which is increasingly evidence-based, advises the clinician to use studies of the mean response...

    journal_title：American journal of hypertension

    pub_type： 社论,评审

    doi：10.1016/j.amjhyper.2003.12.007

    authors： Graves JW,Sheps SG

    更新日期：2004-04-01 00:00:00

  • Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

    abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.09.005

    authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

    更新日期：2006-03-01 00:00:00

  • Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension.

    abstract：:Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.6.419

    authors： Swislocki AL,Hoffman BB,Reaven GM

    更新日期：1989-06-01 00:00:00

  • Adrenocortical activity in the newborn spontaneously hypertensive rat.

    abstract：:Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00010-2

    authors： Malee MP,Wu KY

    更新日期：1999-05-01 00:00:00

  • Prevalence of Hypertension Defined by Central Blood Pressure Measured Using a Type II Device in a Nationally Representative Cohort.

    abstract：OBJECTIVES:Central blood pressure (BP) can be used to define hypertension. A central BP approach may be more sensitive than a conventional brachial BP approach in detecting hypertension. We aimed to compare the 2 approaches in estimating the prevalence hypertension in a nationally representative population. METHODS:A ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx178

    authors： Chuang SY,Chang HY,Cheng HM,Pan WH,Chen CH

    更新日期：2018-02-09 00:00:00

  • Morning blood pressure hyper-reactivity is an independent predictor for hypertensive cardiac hypertrophy in a community-dwelling population.

    abstract：BACKGROUND:Morning blood pressure (BP) surge seems to be a risk factor for cardiovascular events. Although physical activity after arising significantly affects morning BP surge, it has remained unclear whether morning BP surge after controlling for physical activity (morning BP reactivity) is associated with target or...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.06.015

    authors： Kaneda R,Kario K,Hoshide S,Umeda Y,Hoshide Y,Shimada K

    更新日期：2005-12-01 00:00:00

  • Control of hypertension in treated children and its association with target organ damage.

    abstract：BACKGROUND:The aim of our study was to investigate the control of hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We retrospectively reviewed all ABPM studies in our center. Controlled HT was defined as systolic and diastolic BP index (patients' BP divided by the 9...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.218

    authors： Seeman T,Dostálek L,Gilík J

    更新日期：2012-03-01 00:00:00

  • Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats.

    abstract：:The present study was designed to investigate the role of the autonomic nervous system in experimental hypertension induced by chronic administration of N-nitro-L-arginine methyl ester (L-NAME) in the drinking water (1 mg/mL) over 6 days. L-NAME ingestion caused a large rise in resting mean arterial pressure (MAP) (17...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/6.9.806

    authors： Cunha RS,Cabral AM,Vasquez EC

    更新日期：1993-09-01 00:00:00

  • Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.

    abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.278

    authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

    更新日期：2008-11-01 00:00:00

  • Relationship between circulating plasma matrix metalloproteinase-9 (gelatinase-B) concentration and aortic root dilatation.

    abstract：BACKGROUND:Expression of matrix metalloproteinase (MMP) has been shown in aortic dissection and aneurysms indicating increased proteolysis compared with the normal aorta. However, its role in the development of aortic root dilatation has not been studied. We therefore attempted to determine the relationship between aor...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.08.013

    authors： Karakaya O,Barutcu I,Esen AM,Dogan S,Saglam M,Karapinar H,Akgun T,Karavelioglu Y,Esen O,Ozdemir N,Turkmen S,Kaymaz C

    更新日期：2006-04-01 00:00:00

  • Hypertension and arterial stiffness: the Atherosclerosis Risk in Communities Study. ARIC Investigators.

    abstract：:Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00281-2

    authors： Arnett DK,Boland LL,Evans GW,Riley W,Barnes R,Tyroler HA,Heiss G

    更新日期：2000-04-01 00:00:00