Abstract：
:Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adrenocortical activity in the neonatal SHR 1 to 21 days old and its normotensive genetic control, the Wistar-Kyoto rat (WKY). We found a fourfold greater abundance of P450scc mRNA in adrenals of SHR versus WKY day 1 neonates, and increasing but comparable abundance of adrenal P450c11B mRNA on neonatal days 1 to 21. The pattern of P450c11AS mRNA expression was distinctly different in the adrenals of SHR and WKY neonates; the relative abundance of this mRNA in SHR increased 15-fold over the 21-day period examined, whereas that in WKY remained fairly stable. RT-PCR for the presence/abundance of adrenal P450c11B3 mRNA showed absence in day 1 SHR and WKY, comparable abundances on neonatal days 7 and 14, and a distinctly greater abundance in the day 21 SHR adrenals. Peripheral corticosterone levels were threefold greater in the day 1 SHR neonate; aldosterone levels were elevated in both the SHR and WKY day 1 neonate. Thereafter, corticosterone and aldosterone levels were comparable on days 7, 14, and 21, although the anticipated depression in circulating corticosterone levels typical of the stress hyporesponsive period was noted in both SHR and WKY neonates. Although patterns of adrenocortical activity differ in the newborn SHR and WKY rat, our findings do not support an etiologic role for corticosteroids in the reported hypertension of the SHR. However, observed differences in corticosteroid profiles may augment or have a permissive effect upon the etiologic factor(s).
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Malee MP,Wu KYdoi
10.1016/s0895-7061(99)00010-2subject
Has Abstractpub_date
1999-05-01 00:00:00pages
511-8issue
5eissn
0895-7061issn
1941-7225pii
S0895-7061(99)00010-2journal_volume
12pub_type
杂志文章abstract：:Arterial stiffness has been known as a sign of cardiovascular risk since the 19th century. Despite this, accurate measurement and clinical utility have only emerged in recent times. Arterial stiffness and its hemodynamic consequences are now established as predictors of adverse cardiovascular outcome. They are easily ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1038/ajh.2010.192
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:The effect of age on the augmentation index (AI) differs between young adults and the elderly, and the AI reaches a plateau after the age of 60 years. We examined whether the effects of age and an elevation in blood pressure on the AI differ between young adults and the elderly, between subjects with and wit...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu082
更新日期：2014-12-01 00:00:00
abstract：:Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(00)00262-4
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP between individuals with two hypertensive parents, one hypertensive parent, and normotensive parents and whether this increase is apparent with both a...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.09.025
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Hypertension has recently been identified as the leading risk factor for global mortality. This study aims to present the national prevalence of hypertension and prehypertension and, their determinants in Vietnamese adults. METHODS:Nationally representative data were obtained from the National Adult Overwei...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu092
更新日期：2015-01-01 00:00:00
abstract：:The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00484-6
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:We compared the cost-effectiveness of hypertension treatment in non-Hispanic blacks and non-Hispanic whites according to 2014 US hypertension treatment guidelines. METHODS:The cardiovascular disease (CVD) policy model simulated CVD events, quality-adjusted life years (QALYs), and treatment costs in 35- to 7...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw047
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Although several characteristics of aortic function, which are largely determined by age, predict outcomes beyond brachial blood pressure (BP), the extent to which brachial BP control accounts for age-related variations in aortic function is uncertain. We aimed to determine the extent to which brachial BP co...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpv140
更新日期：2016-05-01 00:00:00
abstract：:Abnormal calcium metabolism has been implicated in human hypertension. Caffeine consumption may contribute to hypertension since it increases urinary calcium excretion. Nineteen hypertensive subjects (HTN) and nineteen age and gender matched normotensive controls (NTC) who habitually consumed at least 175 mg caffeine ...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/0895-7061(95)00337-1
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...
journal_title：American journal of hypertension
pub_type：
doi：10.1093/ajh/hpz125
更新日期：2019-11-15 00:00:00
abstract：:The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(98)00027-2
更新日期：1998-05-01 00:00:00
abstract：:The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.2.151
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Cardiovascular diseases (CVD) are responsible for more than 50% of the deaths in patients with end-stage renal disease (ESRD). Sleep apnea (SA) has been recognized as a risk factor for CVD. Previous studies have shown a higher prevalence of SA among patients on dialysis. METHODS:Forty-five nondiabetics pati...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.08.028
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:There is an association between maternal body mass index (BMI) and preeclampsia, but if BMI has an effect on preeclampsia of all severities is debated. If there is an association between maternal height and preeclampsia of all severities is unknown. METHODS:In this population-based cohort study including 50...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.175
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:About one-half of all hypertensive adults do not have their blood pressure controlled. They are often prescribed medications that conform to national guidelines but they continue to have elevated blood pressure. This public health problem might be improved by applying plasma renin guided therapy. RESULTS:A ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx068
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to clarify the response of endothelial connexins to hypertension and antihypertensive drugs. METHODS:Rats remained normotensive (group 1, N = 10) or were made hypertensive using N(omega)-nitro-L-arginine methyl ester (L-NAME) (groups 2 to 4, N = 10/group). Seven weeks later groups ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.08.020
更新日期：2006-02-01 00:00:00
abstract：:Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/2.8.650
更新日期：1989-08-01 00:00:00
abstract：:It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a dou...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0895-7061(96)00507-9
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:In the hypertensive heart, epicardial arteries are not enlarged, despite increased total coronary flow related to augmented cardiac workload, wall stress, and left ventricular (LV) mass. The aims of this study were to assess the impact of different hemodynamic factors and LV mass on baseline left main corona...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.07.003
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1093/ajh/hpt293
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpaa189
更新日期：2020-11-17 00:00:00
abstract：BACKGROUND:As a serious pregnancy-specific condition, preeclampsia (PE) is a serious pregnancy-specific condition characterized by insufficient trophoblastic invasion and shallow placental implantation. Long noncoding RNA uc.187, which is transcribed from an ultra-conserved region is highly expressed in the placental t...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpaa011
更新日期：2020-04-29 00:00:00
abstract：BACKGROUND:Obese and overweight patients are at increased risk of arterial stiffness, and visceral, epicardial and hepatic fat accumulation is associated with cardiovascular disease risk. In general, muscular lipids are stored either in interstitial adipose tissue (extramyocellular lipid (EMCL)) or in lipid droplets wi...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpv041
更新日期：2015-12-01 00:00:00
abstract：:Both nitric oxide (NO) and endothelin-1 (ET-1) are important mediators in the regulation of vascular tone during pregnancy and preeclampsia. This study was designed to investigate the ET-1-induced hypotensive effect in late pregnant rats (P) and in NO-deprived hypertensive pregnant rats (TP), a model of preeclampsia. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(00)01318-2
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu016
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the relationship between nocturnal BP in young adults and cognitive function in midlife remains unclear. METHODS:We used data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young ...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hpv028
更新日期：2015-10-01 00:00:00
abstract：:Intracellular free sodium levels ([Na+]i) were assessed with 23Na nuclear magnetic resonance (NMR) spectroscopy in isolated, Langendorff-perfused normal, compensated hypertrophied, and hypertrophied failing guinea pig hearts under several conditions. Baseline [Na+]i measured with a shift reagent was significantly grea...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00219-F
更新日期：1995-09-01 00:00:00
abstract：:The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(01)02220-8
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:We postulated that acute hypoxemia increases susceptibility to orthostatic hypotension by increasing the sensitivity of cardiovascular baroreceptors. METHODS:Hemodynamics were measured noninvasively in 17 healthy, normotensive subjects while being subjected to decreasing venous return by exposure to lower b...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.02.005
更新日期：2006-09-01 00:00:00
abstract：:Plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigens and activities were measured in 28 patients with hypertension and 12 normal controls. Steady state plasma glucose (SSPG) concentrations were also determined after an infusion of somatostatin, insulin and glucose. Pati...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/0895-7061(95)00442-4
更新日期：1996-05-01 00:00:00
