Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.


BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHODS:ZDF rats were treated with vehicle or AZL-M for 8 weeks. Zucker diabetic lean (ZDL) rats were used as controls. Urine and plasma samples were collected for biochemical analysis, and kidney tissues were used for histopathological and immunohistopathological examination at the end of the 8-week protocol. RESULTS:ZDF rats were diabetic with hyperglycemia and impaired glucose tolerance, and AZL-M ameliorated the diabetic phenotype. ZDF rats were hypertensive compared with ZDL rats (181±6 vs. 129±7mm Hg), and AZL-M decreased blood pressure in ZDF rats (116±7mm Hg). In ZDF rats, there was marked renal damage with elevated proteinuria, albuminuria, nephrinuria, 2-4-fold higher tubular cast formation, and glomerular injury compared with ZDL rats. AZL-M treatment reduced renal damage in ZDF rats. ZDF rats demonstrated renal inflammation and oxidative stress with elevated urinary monocyte chemoattractant protein 1 excretion, renal infiltration of macrophages, and elevated kidney malondialdehyde levels. AZL-M reduced oxidative stress and inflammation in ZDF rats. CONCLUSIONS:Overall, we demonstrate that AZL-M attenuates kidney damage in type 2 diabetes. We further demonstrate that anti-inflammatory and antioxidative activities of AZL-M contribute to its kidney protective action.


Am J Hypertens


Hye Khan MA,Neckář J,Haines J,Imig JD




Has Abstract


2014-08-01 00:00:00














  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

    更新日期:1990-06-01 00:00:00

  • Detection of arteriolar narrowing in fundoscopic examination: evidence of a low performance of direct ophthalmoscopy in comparison with a microdensitometric method.

    abstract:BACKGROUND:Retinal abnormalities, particularly arteriolar narrowing, are powerful predictors of cardiovascular events. The precision of internists and ophthalmologists in the assessment of retinal vessels widths has been disputed but not evaluated against a technology of edge detection. METHODS:Fifty-two patients with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Maestri MM,Fuchs SC,Ferlin E,Pakter HM,Nunes G,Moraes RS,Gus M,Moreira LB,Fuchs FD

    更新日期:2007-05-01 00:00:00

  • Maternal Blood Pressure Before Pregnancy and Sex of the Baby: A Prospective Preconception Cohort Study.

    abstract:BACKGROUND:Population-level sociologic studies have suggested that adverse societal conditions may affect fetal viability in a sex-specific manner and thereby modify the ratio of male vs. female babies. This concept suggests that there may exist certain physiologic features in a woman that relate to her likelihood of d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Retnakaran R,Wen SW,Tan H,Zhou S,Ye C,Shen M,Smith GN,Walker MC

    更新日期:2017-04-01 00:00:00

  • Plasma insulin levels do not change during atrial natriuretic factor infusion in human essential hypertensives.

    abstract::In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ferri C,De Mattia G,Piccoli A,Carlomagno A,Luparini RL,Germanò G,Giarrizzo C,Torregrossa G,Santucci A,Balsano F

    更新日期:1991-11-01 00:00:00

  • Characterization of imidazoline-guanidinium receptive sites in renal medulla from human kidney.

    abstract::Previous studies showed that alpha 2-adrenergic receptors and imidazoline-guanidinium receptive sites (IGRS) are colocalized in rabbit and human renal proximal tubule. In the present study we investigated the localization of these two binding sites in the renal medulla from human kidney. Binding studies performed with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lachaud V,Limon I,Tesson F,Coupry I,Parini A

    更新日期:1992-04-01 00:00:00

  • Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans.

    abstract::Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gainer JV,Brown NJ,Bachvarova M,Bastien L,Maltais I,Marceau F,Bachvarov DR

    更新日期:2000-12-01 00:00:00

  • Ambulatory blood pressure monitoring in offspring of hypertensive patients. Relation to left ventricular structure and function.

    abstract::The relation between 24-h ambulatory blood pressure monitoring and echocardiographic left ventricular (LV) anatomy and function was examined in 30 young, normotensive offspring (16 men, 14 women) of hypertensive, parents and in 20 offspring (12 men, 8 women) of normotensive parents, comparable for age, clinical blood ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Galderisi M,Celentano A,Tammaro P,Mureddu GF,Garofalo M,de Simone G,de Divitiis O

    更新日期:1993-02-01 00:00:00

  • Characterization of a Na+/K+-ATPase inhibitor from human plasma: preliminary data.

    abstract::The role of an endogenous sodium pump inhibitor in the pathogenesis of hypertension has been reported in several papers. Unfortunately, because of the unknown structure and lack of biochemical characterization, some discrepancies have arisen. In this study we report a method to obtain extracts from human plasma that a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Boschi S,Munarini A,Borghi C,Strocchi E,Costa FV,Mussi A,Ettore A

    更新日期:1988-07-01 00:00:00

  • Renal denervation decreases blood pressure in DOCA-treated miniature swine with established hypertension.

    abstract::The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: O'Hagan KP,Thomas GD,Zambraski EJ

    更新日期:1990-01-01 00:00:00

  • Associations of Proatrial Natriuretic Peptide with Components of the Metabolic Syndrome in Adolescents and Young Adults from the General Population.

    abstract:BACKGROUND:In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS:In...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Goharian TS,Goetze JP,Faber J,Andersen LB,Grøntved A,Jeppesen JL

    更新日期:2017-06-01 00:00:00

  • Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus.

    abstract::The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-1 receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a re...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Uehara Y,Hirawa N,Kawabata Y,Numabe A,Gomi T,Ikeda T,Omata M

    更新日期:1999-01-01 00:00:00

  • Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system.

    abstract::Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (AC...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rojas M,Bell TD,Sturgis LC,Springfield V,Janardhanan R,Fleming C,Brands MW

    更新日期:2006-12-01 00:00:00

  • Nonpeptide angiotensin II receptor antagonists.

    abstract::Although the most direct way to interfere with the renin-angiotensin system (RAS) is at the level of the angiotensin II (AII) receptor, the currently available AII receptor antagonists are peptides still retaining significant agonistic properties with the obvious drawbacks of limited stability and lack of oral activit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Timmermans PB,Carini DJ,Chiu AT,Duncia JV,Price WA Jr,Wells GJ,Wong PC,Wexler RR,Johnson AL

    更新日期:1990-08-01 00:00:00

  • Effect of angiotensin converting enzyme inhibitor (lisinopril) on insulin sensitivity and sodium transport in mild hypertension.

    abstract::The purpose of this study was to determine whether antihypertensive therapy with the angiotensin converting enzyme inhibitor lisinopril would alter cell Na+ transport kinetics, metabolic parameters associated with insulin resistance, or both in young adults with mild hypertension. Sixteen young adults (mean age 29 +/-...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Falkner B,Canessa M,Anzalone D

    更新日期:1995-05-01 00:00:00

  • Antihypertensive drug treatment and fibrinolytic function.

    abstract::Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

    更新日期:1998-03-01 00:00:00

  • The effect of sleep intervals on analysis of 24-h ambulatory blood pressure data.

    abstract::Twenty-four hour blood pressure exposure and circadian blood pressure variability may be important predictors of hypertensive end-organ damage. Since sleep is a major determinant of circadian blood pressure decline, day/night blood pressure changes may be affected by sleep intervals. The current study compares 24-h bl...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Rosansky SJ,Menachery SJ,Wagner CM,Jackson K

    更新日期:1995-07-01 00:00:00

  • Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study.

    abstract:BACKGROUND:We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study. METHODS:A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Yang X,He J,Gu D,Hixson JE,Huang J,Rao DC,Shimmin LC,Chen J,Rice TK,Li J,Schwander K,Kelly TN

    更新日期:2014-11-01 00:00:00

  • Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.

    abstract:BACKGROUND:Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofact...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mitchell BM,Cook LG,Danchuk S,Puschett JB

    更新日期:2007-12-01 00:00:00

  • Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats.

    abstract:BACKGROUND:This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue. METHODS:Male Wistar rats were treated for 30 days with 20% ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Freitas RR,Lopes KL,Carillo BA,Bergamaschi CT,Carmona AK,Casarini DE,Furukawa L,Heimann JC,Campos RR,Dolnikoff MS

    更新日期:2007-06-01 00:00:00

  • Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.

    abstract::The objective of the present study was to determine the relationship between plasma renin levels, and the development of hypertension and cardiac hypertrophy in TGR (mREN2)27 hypertensive rats. Systolic blood pressure and left ventricular mass index (LVMI) were measured in transgenic heterozygote and normotensive Spra...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Véniant M,Whitworth CE,Ménard J,Sharp MG,Gonzales MF,Bruneval P,Mullins JJ

    更新日期:1995-12-01 00:00:00

  • The diagnosis of renovascular hypertension. A clinician's viewpoint.

    abstract::The sensitivity and specificity of screening and diagnostic studies for renovascular hypertension has been the focus of debate and disappointment for many years. The use of these studies has been further restricted by the insistence of clinicians that studies provide visual identification of the anatomy of the renal v...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Vidt DG

    更新日期:1991-12-01 00:00:00

  • Arterial stiffness and fetal growth in normotensive pregnancy.

    abstract:BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Elvan-Taspinar A,Franx A,Bots ML,Koomans HA,Bruinse HW

    更新日期:2005-03-01 00:00:00

  • Magnetic resonance imaging compared to echocardiography to assess left ventricular mass in the hypertensive patient.

    abstract::Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient. Magnetic resonance imaging (MRI) may be a more precise and reliable method to quantify the mass of the left ventricule. This study reports the accuracy,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Bottini PB,Carr AA,Prisant LM,Flickinger FW,Allison JD,Gottdiener JS

    更新日期:1995-03-01 00:00:00

  • Hypertension in young patients after renal transplantation: ambulatory blood pressure monitoring versus casual blood pressure.

    abstract::The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Calzolari A,Giordano U,Matteucci MC,Pastore E,Turchetta A,Rizzoni G,Alpert B

    更新日期:1998-04-01 00:00:00

  • Differences in effects of age and blood pressure on augmentation index.

    abstract:BACKGROUND:The effect of age on the augmentation index (AI) differs between young adults and the elderly, and the AI reaches a plateau after the age of 60 years. We examined whether the effects of age and an elevation in blood pressure on the AI differ between young adults and the elderly, between subjects with and wit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tomiyama H,Odaira M,Kimura K,Matsumoto C,Shiina K,Eguchi K,Miyashita H,Shimada K,Yamashina A

    更新日期:2014-12-01 00:00:00

  • Endothelium-derived and intraneuronal nitric oxide-dependent inhibition of norepinephrine efflux from sympathetic nerves by bradykinin.

    abstract::Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium. Moreover, in the absence of vascular endothelium, bradykinin also inhibits n...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Greenberg SS,Peevy K,Tanaka TP

    更新日期:1991-05-01 00:00:00

  • Antihypertensive action of beta-adrenoceptor blocking drugs. The role of intrarenal mechanisms.

    abstract::The different modes of antihypertensive action of beta-adrenoceptor blocking drugs are reviewed with a special emphasis on renal mechanisms of action. Beta-adrenoceptors occur in the kidney at the level of the juxtaglomerular and tubular cells. Direct intrarenal effects of beta-blockers include the decrease in renin r...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Struyker-Boudier HA,Smits JF

    更新日期:1989-11-01 00:00:00

  • Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension.

    abstract:BACKGROUND:Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the pr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Liu X,Zhang Q,Wu H,Du H,Liu L,Shi H,Wang C,Xia Y,Guo X,Li C,Bao X,Su Q,Sun S,Wang X,Zhou M,Jia Q,Zhao H,Song K,Niu K

    更新日期:2015-11-01 00:00:00

  • Plasma-renin response to isotonic volume contraction in young salt-sensitive normotensive men.

    abstract::Salt-sensitive persons have lower plasma renin activity than salt-resistant persons and their plasma renin activity increases less with a low sodium diet or volume depletion, compared to salt-resistant individuals. However, the time course of the renin response to acute volume contraction has not been studied in human...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Schorr U,Schultz C,Sharma AM

    更新日期:2002-01-01 00:00:00

  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract:BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期:2009-09-01 00:00:00