Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases.

Abstract:

:Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for renin that is the rate-limiting enzyme of the renin-angiotensin system. Because the level of angiotensinogen in human beings is close to the Michaelis-Menten constant value for renin, changes in angiotensinogen levels can control the activity of the renin-angiotensin system, and its upregulation may lead to elevated angiotensin peptide levels and increases in blood pressure. Enhanced intrarenal angiotensinogen mRNA or protein levels or both have been observed in multiple models of hypertension including angiotensin II-dependent hypertensive rats, Dahl salt-sensitive hypertensive rats, and spontaneously hypertensive rats, as well as in kidney diseases including diabetic nephropathy, immunoglobulin A (IgA) nephropathy, and radiation nephropathy. Renal angiotensinogen is formed primarily in proximal tubular cells and is secreted into the tubular fluid. Urinary angiotensinogen excretion rates show a clear relationship to kidney angiotensin II contents and kidney angiotensinogen levels, suggesting that urinary angiotensinogen may serve as an index of the intrarenal renin-angiotensin system status. Establishment of concise and accurate methods to measure human angiotensinogen may allow clinical studies that would provide important information regarding the roles of intrarenal angiotensinogen in the development and progression of hypertension and kidney diseases.

journal_name

Am J Hypertens

authors

Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

doi

10.1016/j.amjhyper.2005.11.014

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

541-50

issue

5

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(05)01338-5

journal_volume

19

pub_type

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    authors: Figar S,Galarza C,Petrlik E,Hornstein L,Rodríguez Loria G,Waisman G,Rada M,Soriano ER,de Quirós FG

    更新日期:2006-07-01 00:00:00

  • Endothelin-1-like immunoreactivity in a new rodent model of spontaneous hypertension.

    abstract::The purpose of this study was to determine plasma and tissue endothelin-1 (ET-1)-like immunoreactivity in a new rodent model of spontaneous hypertension. Plasma and tissues were procured from pentobarbital-anesthetized 16- to 18-week-old male hamsters with spontaneous hypertension and genetically/age-matched normotens...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00047-8

    authors: Gulati A,Artwohl JE,Kumar A,Gao XP,Rubinstein I

    更新日期:1998-07-01 00:00:00

  • What, if anything, is controversial about calcium antagonists?

    abstract::Recent publications purporting to show that calcium antagonists, when used for the treatment of hypertension or in the post myocardial infarction patient, would paradoxically increase the rate of heart attack and mortality have cast doubts on the safety and efficacy of this drug class. All three studies are retrospect...

    journal_title:American journal of hypertension

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    doi:10.1016/s0895-7061(96)00387-1

    authors: Messerli FH

    更新日期:1996-12-01 00:00:00

  • Atrial natriuretic peptide mRNA in patients with heart disease.

    abstract::The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to sur...

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    doi:10.1093/ajh/3.3.234

    authors: Haass M,Fischer TA,Hänze J,Saggau W,Lang RE,Dietz R

    更新日期:1990-03-01 00:00:00

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    abstract:BACKGROUND:Strong associations between blood pressure (BP) and overweight raise the question whether overweight children (body mass index (BMI) ≥85th percentile) should be included in the normative database. METHODS:Using the LMS (Lamda-Mu-Sigma) method, we developed age-, gender-, and height-adjusted percentile curve...

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    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajh/hpu208

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    更新日期:2015-05-01 00:00:00

  • Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism.

    abstract::Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated...

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    doi:10.1093/ajh/3.7.533

    authors: Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata K

    更新日期:1990-07-01 00:00:00

  • Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency.

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    pub_type: 杂志文章

    doi:10.1016/s0895-7061(01)02202-6

    authors: Hsu CY,Bates DW,Kuperman GJ,Curhan GC

    更新日期:2001-12-01 00:00:00

  • Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial.

    abstract:BACKGROUND:Recent reports suggest that existing antihypertensive agents may not have sufficient efficacy to control blood pressure (BP) in many patients. Omapatrilat, an agent under development, has been shown to have significantly greater antihypertensive efficacy than existing agents, but may also carry increased ris...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.amjhyper.2003.09.014

    authors: Kostis JB,Packer M,Black HR,Schmieder R,Henry D,Levy E

    更新日期:2004-02-01 00:00:00

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    abstract:BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.52

    authors: Wakabayashi I

    更新日期:2010-06-01 00:00:00

  • Antihypertensive and humoral effects of nifedipine in essential hypertension uncontrolled by hydrochlorothiazide alone.

    abstract::This double-blind placebo controlled study investigated the antihypertensive and humoral effects of nifedipine capsules in patients with essential hypertension inadequately controlled (seated diastolic blood pressure greater than or equal to 95 mm Hg) by hydrochlorothiazide (HCTZ) alone. Nifedipine acutely (first dose...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1093/ajh/2.11.828

    authors: Opsahl JA,Halstenson CE,Abraham PA

    更新日期:1989-11-01 00:00:00

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    abstract:BACKGROUND:Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hyperte...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.369

    authors: Roselló-Lletí E,Rivera M,Martínez-Dolz L,González Juanatey JR,Cortés R,Jordán A,Morillas P,Lauwers C,Calabuig JR,Antorrena I,de Rivas B,Portolés M,Bertomeu V

    更新日期:2009-04-01 00:00:00

  • Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.

    abstract:BACKGROUND:Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. METHODS:We conducted a 7-day potassium supplementation ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.36

    authors: Zhao Q,Gu D,Kelly TN,Hixson JE,Rao DC,Jaquish CE,Chen J,Huang J,Chen CS,Gu CC,Whelton PK,He J

    更新日期:2010-06-01 00:00:00

  • Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension.

    abstract:BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02967-9

    authors: Galderisi M,Caso P,Cicala S,De Simone L,Barbieri M,Vitale G,de Divitiis O,Paolisso G

    更新日期:2002-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00028-n

    authors: Nitenberg A,Antony I,Aptecar E,Arnoult F,Lerebours G

    更新日期:1995-05-01 00:00:00

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    abstract::Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.10.754

    authors: Wolpert HA,Steen SN,Istfan NW,Simonson DC

    更新日期:1992-10-01 00:00:00

  • Plasma pentraxin3 and arterial stiffness in men with obstructive sleep apnea.

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    pub_type: 杂志文章

    doi:10.1038/ajh.2010.248

    authors: Kasai T,Inoue K,Kumagai T,Kato M,Kawana F,Sagara M,Ishiwata S,Ohno M,Yamaguchi T,Momomura S,Narui K

    更新日期:2011-04-01 00:00:00

  • Dapagliflozin does not affect short-term blood pressure variability in patients with type-2 diabetes mellitus.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa207

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    更新日期:2020-12-05 00:00:00

  • Associations of Proatrial Natriuretic Peptide with Components of the Metabolic Syndrome in Adolescents and Young Adults from the General Population.

    abstract:BACKGROUND:In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS:In...

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    更新日期:2017-06-01 00:00:00

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    更新日期:1998-04-01 00:00:00

  • Pressor and bradycardic effects of centrally administered relaxin in conscious rats.

    abstract::The current study tested the hypothesis that centrally administered relaxin elevates arterial pressure in conscious rats and that this hypertensive effect is mediated, at least in part, by central or peripheral vasopressin. Injection of human relaxin (0.068 or 0.34 microgram in 200 nL artificial cerebrospinal fluid) i...

    journal_title:American journal of hypertension

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    doi:10.1016/0895-7061(94)00208-s

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    更新日期:1995-04-01 00:00:00

  • Reversible posterior leukoencephalopathy secondary to indinavir-induced hypertensive crisis: a case report.

    abstract::Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02264-1

    authors: Giner V,Fernández C,Esteban MJ,Galindo MJ,Forner MJ,Guix J,Redón J

    更新日期:2002-05-01 00:00:00

  • Renal depressor mechanisms of physical training in patients with essential hypertension.

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(97)00109-x

    authors: Kohno K,Matsuoka H,Takenaka K,Miyake Y,Nomura G,Imaizumi T

    更新日期:1997-08-01 00:00:00

  • Maternal endothelial progenitor colony-forming units with macrophage characteristics are reduced in preeclampsia.

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    pub_type: 杂志文章

    doi:10.1038/ajh.2009.101

    authors: Lin C,Rajakumar A,Plymire DA,Verma V,Markovic N,Hubel CA

    更新日期:2009-09-01 00:00:00

  • Ambulatory blood pressure and family history of hypertension in healthy men and women.

    abstract:BACKGROUND:Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP between individuals with two hypertensive parents, one hypertensive parent, and normotensive parents and whether this increase is apparent with both a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.09.025

    authors: Goldstein IB,Shapiro D,Guthrie D

    更新日期:2006-05-01 00:00:00

  • Barriers to hypertension care and control in young urban black men.

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(99)00121-1

    authors: Hill MN,Bone LR,Kim MT,Miller DJ,Dennison CR,Levine DM

    更新日期:1999-10-01 00:00:00

  • Diuretics for Hypertension: A Review and Update.

    abstract::This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypert...

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    pub_type: 杂志文章,评审

    doi:10.1093/ajh/hpw030

    authors: Roush GC,Sica DA

    更新日期:2016-10-01 00:00:00

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    abstract::The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.2.105

    authors: Naruse M,Hiroe M,Naruse K,Nagata M,Ohno H,Hashimoto A,Koyanagi H,Sekiguchi M,Demura H,Hirosawa K

    更新日期:1990-02-01 00:00:00

  • Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone spontaneously hypertensive rats.

    abstract::The effect of fish oil on potassium efflux and basal tension in aortas from stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Four-week-old male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean syst...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.7.473

    authors: Smith JM,Paulson DJ,Labak S

    更新日期:1992-07-01 00:00:00

  • Alteration of beta-adrenoceptor function in hypertensive patients with different degrees of left ventricular hypertrophy.

    abstract::Previous assessment of beta-adrenoceptor function has shown alterations in essential hypertension (EH). In the present study, we compared lymphocyte beta-adrenoceptor density (Bmax) and adenylate cyclase (AC) activity stimulated by l-isoproterenol, Gpp(NH)p, Gpp(NH)p + l-isoproterenol, and forskolin in 46 patients wit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.6.266

    authors: Yurenev AP,Parfyonova EV,Krasnikova TL,Aripova NA

    更新日期:1992-06-01 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract:BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpy111

    authors: Simons AN,Moreland CJ,Kushalnagar P

    更新日期:2018-10-15 00:00:00