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Atrial natriuretic peptide mRNA in patients with heart disease.

Abstract：

:The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to surgery. Probes for determination of tissue ANP levels and ANPmRNA concentrations were taken from the right atrium. Both plasma ANP (r = 0.75; P less than .05) and ANPmRNA (r = 0.86; P less than .01) were closely related to mean pulmonary artery pressure. ANPmRNA was also related to plasma ANP (r = 0.60; P less than .07). However, no significant relationships were obtained between either plasma ANP or ANPmRNA and right atrial ANP concentrations. These data suggest that right atrial ANP synthesis is regulated by cardiac filling pressures and possibly by plasma ANP levels, independent from corresponding ANP tissue concentrations.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Haass M,Fischer TA,Hänze J,Saggau W,Lang RE,Dietz R

doi

10.1093/ajh/3.3.234

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

234-6

issue

3

eissn

0895-7061

issn

1941-7225

journal_volume

3

pub_type

杂志文章

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