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Renal denervation decreases blood pressure in DOCA-treated miniature swine with established hypertension.

Abstract：

:The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation (RDX). During the first week post-RDX, MAP decreased from 141 /+- 6 to 121 +/- 3 mm Hg (P less than .05), while sodium balance increased from 0.32 +/- 0.05 to 0.95 +/- 0.14 mEq/kg/day (P less than .05). By 3 weeks post-RDX, MAP remained below normotensive levels while sodium balance returned to the pre-RDX value. There was no significant change in potassium or water balance after RDX. Thus, in DOCA-YMS the renal nerves are important in the maintenance of hypertension. The reduction in MAP with RDX in the absence of a natriuresis suggests a role for renal afferent nerve activity.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

O'Hagan KP,Thomas GD,Zambraski EJ

doi

10.1093/ajh/3.1.62

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

62-4

issue

1

eissn

0895-7061

issn

1941-7225

journal_volume

3

pub_type

杂志文章

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