Hydrogen Sulfide Improves Myocardial Remodeling via Downregulated Angiotensin Ⅱ/AT1R Pathway in Renovascular Hypertensive Rats.

abstract：:We investigated the effects of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers. Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degre...

journal_title：American journal of hypertension

authors： Raman BB,Standley PR,Rajkumar V,Ram JL,Sowers JR

更新日期：1995-02-01 00:00:00

abstract：:In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...

journal_title：American journal of hypertension

authors： Ferri C,De Mattia G,Piccoli A,Carlomagno A,Luparini RL,Germanò G,Giarrizzo C,Torregrossa G,Santucci A,Balsano F

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Endothelial progenitor cells (EPCs) provide paracrine support to the vascular endothelium and may also replace damaged or senescent endothelial cells. Low numbers of endothelial progenitor colony-forming units (CFU-ECs) in culture are a predictive biomarker of vascular disease. We hypothesized that the numbe...

journal_title：American journal of hypertension

authors： Lin C,Rajakumar A,Plymire DA,Verma V,Markovic N,Hubel CA

更新日期：2009-09-01 00:00:00

abstract：:Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

journal_title：American journal of hypertension

authors： Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function a...

journal_title：American journal of hypertension

authors： Mangoni AA,Sherwood RA,Asonganyi B,Swift CG,Thomas S,Jackson SH

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the pr...

journal_title：American journal of hypertension

authors： Liu X,Zhang Q,Wu H,Du H,Liu L,Shi H,Wang C,Xia Y,Guo X,Li C,Bao X,Su Q,Sun S,Wang X,Zhou M,Jia Q,Zhao H,Song K,Niu K

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...

journal_title：American journal of hypertension

authors： Tapia-Castillo A,Carvajal CA,Campino C,Vecchiola A,Allende F,Solari S,García L,Lavanderos S,Valdivia C,Fuentes C,Lagos CF,Martínez-Aguayo A,Baudrand R,Aglony M,García H,Fardella CE

更新日期：2014-03-01 00:00:00

abstract：:Primary investigators of randomized drug trials in hypertension were invited to rate quality of such trials. The intention of the survey was to ask if antihypertensive drug therapy reduces incidence of coronary heart disease (CHD) in hypertensive patients. Response was obtained for 7 of the 11 invited investigators, c...

journal_title：American journal of hypertension

authors： Holme I,Ekelund LG,Hjermann I,Leren P

更新日期：1994-08-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...

journal_title：American journal of hypertension

authors： Schiffrin EL

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Hypertension treatment is important in managing chronic renal insufficiency (CRI). Little is known, however, about the blood pressure (BP) control achieved or the pattern of antihypertensive drug prescription among CRI patients. METHODS:Using computerized medical records, we studied 3,089 adult hypertensive...

journal_title：American journal of hypertension

authors： Hsu CY,Bates DW,Kuperman GJ,Curhan GC

更新日期：2001-12-01 00:00:00

abstract：:In this study we have compared Ca2+ efflux in cultured aortic smooth muscle cells derived from male, 10-week-old spontaneously hypertensive and Wistar-Kyoto rats. The role of Ca(2+)-dependent protein kinase C and Ca2+ uptake in the regulation of the Ca2+ pump and Na(+)-Ca2+ exchange mediated Ca2+ efflux were investiga...

journal_title：American journal of hypertension

authors： Chen S,Monteith GR,Roufogalis BD

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...

journal_title：American journal of hypertension

authors： Liu YP,Kuznetsova T,Jin Y,Thijs L,Asayama K,Gu YM,Bochud M,Verhamme P,Struijker-Boudier HA,Staessen JA

更新日期：2013-03-01 00:00:00

abstract：:The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...

journal_title：American journal of hypertension

authors： Fallo F,Sonino N,Barzon L,Pistorello M,Pagotto U,Paoletta A,Boscaro M

更新日期：1996-01-01 00:00:00

abstract：:Nitric oxide synthase (NOS) blockade increases blood pressure (BP) and modifies glomerular and tubular function. Angiotensin II (AII) blockade restores glomerular and tubular function but does not lower BP. We measured plasma renin activity (PRA), plasma (AIIp), and kidney tissue (AIIk) AII with radioimmunoassay to in...

journal_title：American journal of hypertension

authors： Garcia GE,Brown MR,Wead LM,Braun S,Gabbai FB

更新日期：1997-10-01 00:00:00

abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...

journal_title：American journal of hypertension

authors： Wimalawansa SJ

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Nifedipine has been reported to cause impairment of insulin sensitivity. But recently a controlled-released formulation of nifedipine (nifedipine-GITS) has been reported that it could improve insulin sensitivity. METHODS:We evaluated insulin sensitivity in two groups of essential hypertensive subjects befor...

journal_title：American journal of hypertension

authors： Koyama Y,Kodama K,Suzuki M,Harano Y

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Calcium channel blockers such as amlodipine are effective antihypertensive agents. In this study we investigated the effects of amlodipine on vascular oxidative stress, expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1), and endothelial function in angiotensin (Ang) II-infused ra...

journal_title：American journal of hypertension

authors： Zhou MS,Jaimes EA,Raij L

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:A resequencing study of renal epithelial sodium channel (ENaC) genes was conducted to identify rare variants associated with blood pressure (BP) salt-sensitivity. METHODS:The Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study was conducted among 1,906 participants who underwent a 7-day low-sod...

journal_title：American journal of hypertension

authors： Gu X,Gu D,He J,Rao DC,Hixson JE,Chen J,Li J,Huang J,Wu X,Rice TK,Shimmin LC,Kelly TN

更新日期：2018-01-12 00:00:00

abstract：:Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (AC...

journal_title：American journal of hypertension

authors： Rojas M,Bell TD,Sturgis LC,Springfield V,Janardhanan R,Fleming C,Brands MW

更新日期：2006-12-01 00:00:00

abstract：:The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

journal_title：American journal of hypertension

authors： Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofact...

journal_title：American journal of hypertension

authors： Mitchell BM,Cook LG,Danchuk S,Puschett JB

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:This study investigated the relationship of ethnicity to the differences between blood pressure (BP) measured in a clinic setting and by ambulatory blood pressure monitoring (ABPM) in individuals with a previous diagnosis of hypertension (HT) and without a previous diagnosis of hypertension (NHT). METHODS:A...

journal_title：American journal of hypertension

authors： Martin U,Haque MS,Wood S,Greenfield SM,Gill PS,Mant J,Mohammed MA,Heer G,Johal A,Kaur R,Schwartz C,McManus RJ

更新日期：2015-06-01 00:00:00

abstract：:Blood pressure normally follows a characteristic pattern throughout the 24 h cycle with daytime pressures higher than nighttime pressures. Patients lacking a nocturnal decrease in pressure have a higher incidence of end organ damage. This investigation was designed to characterize the diurnal pattern of blood pressure...

journal_title：American journal of hypertension

authors： Marx MA,Gardner SF,Ketel BL

更新日期：1996-08-01 00:00:00

abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

journal_title：American journal of hypertension

authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...

journal_title：American journal of hypertension

authors： Pierdomenico SD,Pierdomenico AM,Di Tommaso R,Coccina F,Di Carlo S,Cuccurullo F,Porreca E

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...

journal_title：American journal of hypertension

authors： Cacciolati C,Hanon O,Alpérovitch A,Dufouil C,Tzourio C

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

journal_title：American journal of hypertension

authors： Notarius CF,Morris BL,Floras JS

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The X-linked angiotensin II type-2 receptor (AT2R) gene 1675G/A polymorphism is located in the short intron 1 of the AT2R gene within a sequence motif conforming to a splice branch site. AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenot...

journal_title：American journal of hypertension

authors： Liu YP,Kuznetsova T,Thijs L,Jin Y,Schmitz B,Brand SM,Brand E,Manunta P,Bianchi G,Struijker-Boudier H,Staessen JA

更新日期：2011-12-01 00:00:00

abstract：:After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of bo...

journal_title：American journal of hypertension

authors： Folkow B

更新日期：1989-03-01 00:00:00

abstract：:The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase i...

journal_title：American journal of hypertension

authors： Naruse M,Hiroe M,Naruse K,Nagata M,Ohno H,Hashimoto A,Koyanagi H,Sekiguchi M,Demura H,Hirosawa K

更新日期：1990-02-01 00:00:00