Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system.


:Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (ACEI) were used to inhibit angiotensin II (AngII) production, to test the hypothesis that a balance between GFR and AngII is required for normal BP early in diabetes. Diabetes was induced with streptozotocin (STZ) (35 mg/kg intravenously); and after 7 days of hyperglycemia (range: 408 to 486 mg/dL), insulin was intravenously infused continuously for a 4-day normoglycemic recovery period. In normal kidney (NK) rats, diabetes increased PRA (2.4 +/- 0.6 to 4.6 +/- 0.5 ngAI/mL/h) and GFR (2.9 +/- 0.1 to 3.5 +/- 0.2 mL/min), and there was no change in mean arterial pressure (MAP) (89 +/- 1 v 91 +/- 1 mm Hg, measured 18 h/day). There was no change in either GFR or AngII during diabetes in RK+ACEI rats, and their MAP also did not change. Thus, the maintenance of normal MAP was accompanied by a balance between GFR and AngII in both of those groups. In NK+ACEI rats, however, GFR increased significantly with no change in AngII, and MAP decreased significantly during diabetes by approximately 8 mm Hg. In RK rats, PRA increased (0.5 +/- 0.1 to 2.6 +/- 0.5) but GFR did not increase, and MAP increased significantly by approximately 16 mm Hg. All rats were in sodium balance by day 4 of diabetes. These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not.


Am J Hypertens


Rojas M,Bell TD,Sturgis LC,Springfield V,Janardhanan R,Fleming C,Brands MW




Has Abstract


2006-12-01 00:00:00














  • Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study.

    abstract:BACKGROUND:Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in the understanding of the management of high BP in the aged. We explored antihypertensive treatment and control among elderly hypertensive participants free from overt card...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Chowdhury EK,Nelson MR,Ernst ME,Margolis KL,Beilin LJ,Johnston CI,Woods RL,Murray AM,Wolfe R,Storey E,Shah RC,Lockery JE,Tonkin AM,Newman AB,Williamson JD,Abhayaratna WP,Stocks NP,Fitzgerald SM,Orchard SG,Trevaks RE

    更新日期:2020-04-01 00:00:00

  • Endothelium-derived and intraneuronal nitric oxide-dependent inhibition of norepinephrine efflux from sympathetic nerves by bradykinin.

    abstract::Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium. Moreover, in the absence of vascular endothelium, bradykinin also inhibits n...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Greenberg SS,Peevy K,Tanaka TP

    更新日期:1991-05-01 00:00:00

  • The association of nephrolithiasis with hypertension and obesity: a review.

    abstract::Kidney stones affect hypertensive patients disproportionately compared to normotensive individuals. On the other hand, some prospective data suggest that a history of nephrolithiasis was associated with a greater tendency to develop hypertension. Newer epidemiologic data also link obesity and diabetes, features of the...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Obligado SH,Goldfarb DS

    更新日期:2008-03-01 00:00:00

  • Intrafamilial aggregation and heritability of left ventricular geometric remodeling is independent of cardiac mass in families of African ancestry.

    abstract:BACKGROUND:Whether left ventricular (LV) geometric remodeling, as indexed by relative wall thickness (RWT), aggregates in families and is inherited independent of LV mass (LVM) and additional confounders is uncertain. METHODS:We determined whether RWT as assessed from 2D targeted M-mode echocardiography shows intrafam...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Peterson VR,Norton GR,Redelinghuys M,Libhaber CD,Maseko MJ,Majane OH,Brooksbank R,Woodiwiss AJ

    更新日期:2015-05-01 00:00:00

  • Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases.

    abstract::Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for reni...

    journal_title:American journal of hypertension



    authors: Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

    更新日期:2006-05-01 00:00:00

  • Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.

    abstract::In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Khaw KT,Barrett-Connor E

    更新日期:1990-06-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract::Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Devereux RB

    更新日期:1989-08-01 00:00:00

  • Protein phosphorylation and intracellular free calcium in platelets of patients with essential hypertension.

    abstract::Platelet intracellular free calcium concentration [Ca2+]i from patients with essential hypertension has been found to be elevated, but the intracellular effects of this increase are still unclear. As protein phosphorylation is an important regulatory step in cell activation and increased protein phosphorylation has be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Haller H,Lindschau C,Quass P,Distler A

    更新日期:1992-03-01 00:00:00

  • History of antihypertensive therapy influences the relationships of alcohol with blood pressure and pulse pressure in older men.

    abstract:BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wakabayashi I

    更新日期:2010-06-01 00:00:00

  • Renal macrostructure and cortical circulation in hypertension assessed by dynamic computed tomography.

    abstract::The aim of this study was to assess the macrostructure of the kidney and the grade of heterogeneity in renal cortical circulation in the early stages of essential hypertension. The subjects consisted of 84 patients (<50 years old) who underwent dynamic computed tomography (CT) because of various abdominal diseases and...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kojima S,Shida M,Tanaka K,Takano H,Yokoyama H,Kuramochi M

    更新日期:2001-06-01 00:00:00

  • Association of longitudinal changes in NT-proBNP with changes in Left Atrial Volume and Function: MESA.

    abstract:BACKGROUND:The mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multi-ethnic population. METHODS:From the prospective cohort study, the Multi-Ethnic ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Varadarajan V,Ambale-Venkatesh B,Hong SY,Habibi M,Ashikaga H,Wu CO,Chen LY,Heckbert SR,Bluemke DA,Lima JAC

    更新日期:2021-01-25 00:00:00

  • Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?

    abstract:BACKGROUND:The X-linked angiotensin II type-2 receptor (AT2R) gene 1675G/A polymorphism is located in the short intron 1 of the AT2R gene within a sequence motif conforming to a splice branch site. AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenot...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Liu YP,Kuznetsova T,Thijs L,Jin Y,Schmitz B,Brand SM,Brand E,Manunta P,Bianchi G,Struijker-Boudier H,Staessen JA

    更新日期:2011-12-01 00:00:00

  • Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.

    abstract::Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kahn AM,Allen JC,Seidel CL,Song T

    更新日期:2000-04-01 00:00:00

  • Effects of hyperinsulinemia on the regulation of regional blood flow and blood pressure in anesthetized dogs: hemodynamic role of nitric oxide.

    abstract::The purpose of this study was to investigate whether acute hyperinsulinemia induces selective hemodynamic effects in the mesenteric, renal, and iliac vascular beds, and to determine whether nitric oxide (NO) plays a role in the regulation of blood flow and mean arterial pressure (MAP) during acute hyperinsulinism. In ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Villa E,García-Robles R,Romero JC

    更新日期:1998-10-01 00:00:00

  • High-fructose feeding elicits insulin resistance without hypertension in normal mongrel dogs.

    abstract::This study was undertaken to characterize blood pressure (by continuous blood pressure recording), renal hemodynamics, and excretory function in high-fructose-fed insulin-resistant dogs. We fed 10 mongrel dogs for 28 days with a normal sodium diet containing 60% of the calories either as fructose (n = 6) or dextrose (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pamies-Andreu E,Fiksen-Olsen M,Rizza RA,Romero JC

    更新日期:1995-07-01 00:00:00

  • Feasibility of home blood pressure measurement in elderly individuals: cross-sectional analysis of a population-based sample.

    abstract:BACKGROUND:Home blood pressure measurement (HBPM) is recommended by hypertension guidelines, particularly in the elderly. However, feasibility of HBPM in this age group has not been fully established. Our objective was therefore to assess HBPM feasibility in elderly individuals of the general population. METHODS:After...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Cacciolati C,Tzourio C,Dufouil C,Alpérovitch A,Hanon O

    更新日期:2012-12-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract::Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期:1996-06-01 00:00:00

  • Clofibrate acutely reverses saline-induced endothelial dysfunction: role of calcium-activated potassium channels.

    abstract:BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sankaralingam S,Desai KM,Wilson TW

    更新日期:2006-11-01 00:00:00

  • Sleep apnea, hypertension, and the effects of continuous positive airway pressure.

    abstract:BACKGROUND:Sleep apnea is being studied as a risk factor for hypertension. This observational chart review was conducted to determine the long-term effects of continuous positive airway pressure (CPAP) treatment on blood pressure (BP) in a sample of sleep apnea patients from urban and rural populations. METHODS:This s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Dhillon S,Chung SA,Fargher T,Huterer N,Shapiro CM

    更新日期:2005-05-01 00:00:00

  • The relationship between birth weight and blood pressure in childhood: a population-based study.

    abstract:BACKGROUND:Low birth weight has been associated with increased risk of hypertension later in life. The aim of this study was to evaluate the association between birth weight and blood pressure (BP) in healthy 9- to 10-year-old Icelandic children. METHODS:Each child underwent 4 seated BP measurements, and the BP percen...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Steinthorsdottir SD,Eliasdottir SB,Indridason OS,Palsson R,Edvardsson VO

    更新日期:2013-01-01 00:00:00

  • Hydrogen Sulfide Improves Myocardial Remodeling via Downregulated Angiotensin Ⅱ/AT1R Pathway in Renovascular Hypertensive Rats.

    abstract:BACKGROUND:Hydrogen sulfide (H2S) is an important endogenous gaseous transmitter in many physiological functions. Plasma H2S decreased, and angiotensin II (Ang II) type 1 receptor (AT1R) increased in the myocardial tissues in 2-kidney 1-clip (2K1C) rats than in normotensive rats. Accumulating evidences suggest that H2S...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Liu SY,Duan XC,Jin S,Teng X,Xiao L,Xue HM,Wu YM

    更新日期:2017-01-01 00:00:00

  • Platelet and erythrocyte membrane microviscosity in Lyon hypertensive rats.

    abstract::The altered membrane microviscosity demonstrated in various cells of spontaneously hypertensive rats (SHR) and essential hypertensive (EH) patients has been proposed to play an important role in the pathogenesis of genetic forms of hypertension. The aim of this study was to evaluate possible changes of membrane microv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Le Quan Sang KH,Kunes J,Zicha J,Vincent M,Sassard J,Devynck MA

    更新日期:1994-03-01 00:00:00

  • Activation of nitric oxide synthesis in vascular smooth muscle cells and macrophages during development in spontaneously hypertensive rats.

    abstract::We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activatio...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Xiao J,Pang PK

    更新日期:1996-04-01 00:00:00

  • Sodium regulation in the affinity of renal alpha 2-adrenoceptors for epinephrine in Sabra salt-sensitive and salt-resistant rats.

    abstract::Sodium ions markedly decreased in vitro renal alpha 2-adrenoceptor affinity for epinephrine in Sabra hypertensive (SBH) but not in normotensive (SBN) rats. Under these conditions, affinity of alpha 1-adrenoceptor for epinephrine was unchanged in SBH and SBN rats. If these data could be confirmed in vivo, the sodium io...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Qing W,Dausse JP,Ben-Ishay D

    更新日期:1991-03-01 00:00:00

  • In vitro relaxation of phenylephrine- and angiotensin II-contracted aortic rings by beta-estradiol.

    abstract::In vivo studies suggest that 17 beta-estradiol (beta E) may regulate vascular tone. Results of recent studies suggest that beta E exerts rapid effects on intracellular calcium, possibly via cell surface receptors, distinct from conventional nuclear receptors for steroids. The present study was designed to determine wh...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ravi J,Mantzoros CS,Prabhu AS,Ram JL,Sowers JR

    更新日期:1994-12-01 00:00:00

  • Salt intake and hypertensive renal injury in African-Americans. A therapeutic perspective.

    abstract::Hypertensive renal injury is a major identifiable cause of end-stage renal disease in African-Americans. A complex nexus of sociologic, biologic, environmental, and sociocultural variables are involved in mediating this risk and interrelate with dietary salt consumption and salt sensitivity. It is likely that dietary ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Weir MR

    更新日期:1995-06-01 00:00:00

  • Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.

    abstract:BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

    更新日期:2014-11-01 00:00:00

  • Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension.

    abstract::Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Swislocki AL,Hoffman BB,Reaven GM

    更新日期:1989-06-01 00:00:00

  • New approaches to screening for vascular and cardiac risk.

    abstract::Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Cohn JN

    更新日期:2001-06-01 00:00:00