Antihypertensive effects of oral calcium supplementation may be mediated through the potent vasodilator CGRP.

Abstract:

:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be mediated are entirely unknown. The present study confirmed that daily supplementation with 1.4 g of elemental calcium led to a significant decrease in both systolic and diastolic blood pressures (P < .01). Decrease in blood pressure was negatively correlated with increase in plasma calcitonin gene-related peptide (CGRP), measured with radioimmunoassay and by radioreceptor assay (P < .001), and positively correlated with decrease in intact parathyroid hormone (PHT) (P < .05). Following cessation of calcium supplementation, plasma CGRP levels and the blood pressure both reverted back to the base-line values, suggesting a direct effect of supplemented calcium on these two parameters.

journal_name

Am J Hypertens

authors

Wimalawansa SJ

doi

10.1093/ajh/6.12.996

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

996-1002

issue

12

eissn

0895-7061

issn

1941-7225

journal_volume

6

pub_type

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