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Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentration.

Abstract：

BACKGROUND:All renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin-angiotensin-aldosterone activity. We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone. METHODS:We analyzed plasma levels of prorenin, renin, and aldosterone, as well as their interactions, in 129 young blacks and whites. RESULTS:Blacks had lower plasma renin concentration (PRC) and PRA, but had prorenin levels similar to whites (69 pg/ml in blacks vs. 62 pg/ml in whites, P = 0.41). As a result, the renin-to-total renin ratio was significantly lower in blacks (11.5% in blacks as compared to 19.8% in whites; P = 0.0001). Because prorenin also resides in tissues including the adrenal where it can bind to a specific receptor to generate angiotensin II, we examined the relationship of prorenin levels to plasma aldosterone concentrations (PAC). While a positive association between PRC and PAC was found in both blacks and whites, PAC was positively related to prorenin in whites (P = 0.04) but negatively in blacks, an observation that we hypothesize was due to reduced prorenin-to-renin conversion in blacks. CONCLUSIONS:We observed a disproportionately high level of prorenin in blacks. These high circulating prorenin levels however do not result in greater adrenal angiotensin II and aldosterone production in healthy young blacks.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Tu W,Eckert GJ,Pratt JH,Jan Danser AH

doi

10.1038/ajh.2012.83

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1030-4

issue

9

eissn

0895-7061

issn

1941-7225

pii

ajh201283

journal_volume

25

pub_type

杂志文章

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