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Chemerin as a Driver of Hypertension: A Consideration.

Abstract：

:The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with the goal of understanding whether and how chemerin drives (pathological) changes in blood pressure such that it could be interfered with therapeutically. We dissect the biosynthesis of chemerin and how current antihypertensive medications change chemerin metabolism. This is followed with a review of what is known about where chemerin is synthesized in the body and what chemerin and its receptors can do to the physiological function of organs important to blood pressure determination (e.g., brain, heart, kidneys, blood vessels, adrenal, and sympathetic nervous system). We synthesize from the literature our best understanding of the mechanisms by which chemerin modifies blood pressure, with knowledge that plasma/serum levels of chemerin may be limited in their pathological relevance. This review reveals several gaps in our knowledge of chemerin biology that could be filled by the collective work of protein chemists, biologists, pharmacologists, and clinicians.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Ferland DJ,Mullick AE,Watts SW

doi

10.1093/ajh/hpaa084

subject

Has Abstract

pub_date

2020-11-03 00:00:00

pages

975-986

issue

11

eissn

0895-7061

issn

1941-7225

pii

5846161

journal_volume

33

pub_type

杂志文章

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