当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives.

Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives.

Abstract：

BACKGROUND:In hypertensives, nondippers are more likely than dippers to suffer silent, as well as overt, hypertensive target organ damage. In this study, we investigated whether a nondipper status was associated with target organ damage in normotensives. METHODS:We performed ambulatory blood pressure (BP) monitoring, echocardiography, and carotid ultrasonography and measured natriuretic peptides and urinary albumin (UAE) in 74 normotensive subjects with the following criteria: 1) clinical BP <140/90 mm Hg; 2) average 24-h ambulatory BP <125/80 mm Hg. RESULTS:The left ventricular mass index (LVMI) and the relative wall thickness (RWT) measured by echocardiography were greater in nondippers than dippers (LVMI: 103 +/- 26 v 118 +/- 34 g/m(2), P <.05; RWT: 0.38 +/- 0.07 v 0.43 +/- 0.09, P <.01). Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were higher in nondippers than dippers (ANP: 14 +/- 10 v 36 +/- 63 pg/mL, P <.01; BNP: 16 +/- 12 v 62 +/- 153 pg/mL, P <.05). There were no significant differences in UAE and intima-media thickness measured by carotid ultrasonography. CONCLUSIONS:Normotensive nondipping may not reflect renal damage, but may have a predominant effect on cardiac damage. Nondipping of nocturnal BP seems to be a determinant of cardiac hypertrophy and remodeling, and may result in a cardiovascular risk independent of ambulatory BP levels in normotensives.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Hoshide S,Kario K,Hoshide Y,Umeda Y,Hashimoto T,Kunii O,Ojima T,Shimada K

doi

10.1016/s0895-7061(03)00567-3

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

434-8

issue

6

eissn

0895-7061

issn

1941-7225

pii

S0895706103005673

journal_volume

16

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Clinical studies of drug reversal of hypertensive left ventricular hypertrophy.

    abstract：:Because left ventricular hypertrophy (LVH) is a strong risk factor for cardiac morbidity and mortality considerable interest has been generated concerning the possible effects of modifying LVH in hypertensive patients. In animal models disproportionate regression of left ventricular (LV) mass in relation to blood pres...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,评审

    doi：10.1093/ajh/3.6.512

    authors： Liebson PR

    更新日期：1990-06-01 00:00:00

  • Clinical experience with the angiotensin II receptor antagonist losartan. A preliminary report.

    abstract：:The nonpeptide angiotensin II (AII)-receptor antagonist losartan is a selective blocker of the pressor effects of AII. It is now being evaluated as an anti-hypertensive drug in multicenter clinical trials in the United States and other countries. Preliminary inpatient studies have shown that after 5 days of treatment,...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1093/ajh/5.12.247s

    authors： Weber MA

    更新日期：1992-12-01 00:00:00

  • Relevance of the trough-to-peak ratio to the 24 h blood pressure load.

    abstract：:The ambulatory blood pressure load is generally defined as the proportion of elevated systolic or diastolic pressures over a 24 h period. This value represents the chronic pressure overload that induces myocardial and vascular damage associated with the hypertensive disease process. Blood pressure load has been define...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/0895-7061(96)87761-2

    authors： White WB

    更新日期：1996-10-01 00:00:00

  • Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.

    abstract：BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa021

    authors： Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

    更新日期：2020-04-29 00:00:00

  • Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension.

    abstract：:Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(97)00320-8

    authors： Dominguez LJ,Barbagallo M,Jacober SJ,Jacobs DB,Sowers JR

    更新日期：1997-12-01 00:00:00

  • Intrarenal arterial network renin content and inhibition by EMD 58265.

    abstract：:The renin content, expressed as nanograms of angiotensin I/hour/milligram, of a rabbit intrarenal arterial network (IAN) was compared to that of renal cortical samples from the same animal. Tissues from six rabbits were studied. Cortical tissue (RC) and an IAN with some glomeruli and attached arterioles (IAN + glomeru...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(94)00073-k

    authors： Birt PC,Zimmerman BG

    更新日期：1995-04-01 00:00:00

  • Heritability of the retinal microcirculation in Flemish families.

    abstract：BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hps064

    authors： Liu YP,Kuznetsova T,Jin Y,Thijs L,Asayama K,Gu YM,Bochud M,Verhamme P,Struijker-Boudier HA,Staessen JA

    更新日期：2013-03-01 00:00:00

  • Blood Pressure, Chronic Kidney Disease Progression, and Kidney Allograft Failure in Kidney Transplant Recipients: A Secondary Analysis of the FAVORIT Trial.

    abstract：BACKGROUND:In chronic kidney disease, intensive systolic blood pressure (SBP) control reduces mortality at a cost of greater acute kidney injury risk. Kidney transplantation involves implantation of denervated kidneys and immunosuppressive medications that increase acute kidney injury risk. The optimal blood pressure (...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ajh/hpz095

    authors： Malhotra R,Katz R,Weiner DE,Levey AS,Cheung AK,Bostom AG,Ix JH

    更新日期：2019-08-14 00:00:00

  • High dietary salt enhances acute depressor responses to metformin.

    abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00119-3

    authors： Muntzel MS,Nyeduala B,Barrett S

    更新日期：1999-12-01 00:00:00

  • Association of Maternal Plasma Folate and Cardiometabolic Risk Factors in Pregnancy with Elevated Blood Pressure of Offspring in Childhood.

    abstract：BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx003

    authors： Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

    更新日期：2017-05-01 00:00:00

  • Ionized magnesium and calcium levels in umbilical cord serum of pregnant women with transient hypertension during labor.

    abstract：:Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotens...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/6.6.542

    authors： Handwerker SM,Altura BT,Royo B,Altura BM

    更新日期：1993-06-01 00:00:00

  • Red blood cell Na+/H+ and Li+/Na+ exchange in patients with essential hypertension.

    abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.12.903

    authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

    更新日期：1989-12-01 00:00:00

  • Sodium lithium countertransport and blood pressure. Longitudinal findings.

    abstract：:A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(96)00261-0

    authors： Trevisan M,Strazzullo P,Cappuccio F,Jossa F,Iacone R,Russo I,Farinaro E

    更新日期：1996-11-01 00:00:00

  • Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.

    abstract：:It is likely that a number of independent heritable traits, each encoded by a singular gene, contribute to pathologic elevations in blood pressure in humans. Genetic polymorphisms of individual genes may result in intermediate phenotypes which, by themselves, do not raise blood pressure, but, coupled with environmenta...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00155-I

    authors： Freeman K,Farrow S,Schmaier A,Freedman R,Schork T,Lockette W

    更新日期：1995-09-01 00:00:00

  • Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosis.

    abstract：BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.04.002

    authors： Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

    更新日期：2006-11-01 00:00:00

  • Effect of surgical treatment on hypertension in Cushing's syndrome.

    abstract：:The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/0895-7061(95)00299-5

    authors： Fallo F,Sonino N,Barzon L,Pistorello M,Pagotto U,Paoletta A,Boscaro M

    更新日期：1996-01-01 00:00:00

  • Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats.

    abstract：BACKGROUND:Calcium channel blockers such as amlodipine are effective antihypertensive agents. In this study we investigated the effects of amlodipine on vascular oxidative stress, expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1), and endothelial function in angiotensin (Ang) II-infused ra...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2003.09.007

    authors： Zhou MS,Jaimes EA,Raij L

    更新日期：2004-02-01 00:00:00

  • Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.

    abstract：BACKGROUND:Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). METHODS:Outpatient blood press...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.106

    authors： Bhatnagar V,Liu L,Nievergelt CM,Richard E,Brophy VH,Pandey B,Lipkowitz MS,O'Connor DT

    更新日期：2012-11-01 00:00:00

  • Atrial natriuretic factor modulates the plasma levels of a Na+/K+ATPase inhibitor in volume expanded borderline hypertensives.

    abstract：:To evaluate the existence of a relationship between atrial natriuretic factor (ANF) and plasma Na+/K+ATPase inhibitory activity in humans, we examined the hemodynamic and humoral response to volume expansion in 41 borderline hypertensive patients (BHT) with either normal (n = 33) or low plasma renin activity (n = 8). ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.7.618

    authors： Borghi C,Boschi S,Costa FV,Ambrosioni E

    更新日期：1991-07-01 00:00:00

  • A clinical phenotype mimicking essential hypertension in a newly discovered family with Liddle's syndrome.

    abstract：BACKGROUND:Liddle's syndrome (LS) is a monogenic form of hypertension simulating a mineralocorticoid excess, and is currently suspected in young hypokalemic hypertensives. The aims of the study were: (i) to evaluate the clinical phenotype of LS in a newly identified Italian family of Sicilian origin carrying a gain-of-...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.76

    authors： Rossi E,Farnetti E,Nicoli D,Sazzini M,Perazzoli F,Regolisti G,Grasselli C,Santi R,Negro A,Mazzeo V,Mantero F,Luiselli D,Casali B

    更新日期：2011-08-01 00:00:00

  • Worldwide trends and shortcomings in the treatment of hypertension.

    abstract：:Despite advances in the availability and quality of antihypertensive medications and the institution of national programs to educate people about the seriousness of hypertension, much remains to be done. The percentages of people who are aware of their disease, are being treated for it, and are achieving adequate cont...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(00)00273-9

    authors： Julius S

    更新日期：2000-05-01 00:00:00

  • Comparison of the measures of pulsatile arterial function between asymptomatic younger adult smokers and former smokers: the Bogalusa Heart Study.

    abstract：:Cigarette smoking, an established cardiovascular (CV) disease risk factor, is known to impair pulsatile arterial function. However, information is scant in this regard on asymptomatic younger adult former smokers. As part of the Bogalusa Heart Study, the pulsatile arterial function was examined noninvasively in 278 no...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.02.004

    authors： Li H,Srinivasan SR,Berenson GS

    更新日期：2006-09-01 00:00:00

  • Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.

    abstract：:In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.6.505

    authors： Khaw KT,Barrett-Connor E

    更新日期：1990-06-01 00:00:00

  • Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

    abstract：:The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02220-8

    authors： Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

    更新日期：2001-11-01 00:00:00

  • Erythrocyte cation transport systems and membrane lipids in insulin-dependent diabetes.

    abstract：:The relationship between erythrocyte cation transport systems and membrane and plasma lipids was examined in normal men and patients with insulin-dependent diabetes mellitus (IDDM). Different measurements of erythrocyte transport systems were obtained in patients with IDDM and in age- and weight-matched healthy men: N...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/6.9.763

    authors： Lijnen P,Fenyvesi A,Bex M,Bouillon R,Amery A

    更新日期：1993-09-01 00:00:00

  • Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin.

    abstract：BACKGROUND:Marinobufagenin (MBG) is an endogenous Na/K-ATPase inhibitor, a natriuretic and a vasoconstrictor. MBG is implicated in salt-sensitive hypertension, cardiac hypertrophy, and initiate the pro-fibrotic signaling. Previously it was demonstrated that immunoneutralization of an endogenous MBG by 3E9 anti-MBG-anti...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv155

    authors： Grigorova YN,Juhasz O,Zernetkina V,Fishbein KW,Lakatta EG,Fedorova OV,Bagrov AY

    更新日期：2016-05-01 00:00:00

  • Hypotensive effect of endothelin-1 in nitric oxide-deprived, hypertensive pregnant rats.

    abstract：:Both nitric oxide (NO) and endothelin-1 (ET-1) are important mediators in the regulation of vascular tone during pregnancy and preeclampsia. This study was designed to investigate the ET-1-induced hypotensive effect in late pregnant rats (P) and in NO-deprived hypertensive pregnant rats (TP), a model of preeclampsia. ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01318-2

    authors： Matz RL,Van Overloop B,Gairard A

    更新日期：2001-06-01 00:00:00

  • Atrial natriuretic peptide mRNA in patients with heart disease.

    abstract：:The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to sur...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.3.234

    authors： Haass M,Fischer TA,Hänze J,Saggau W,Lang RE,Dietz R

    更新日期：1990-03-01 00:00:00

  • Central attenuation of baroreflex precedes the development of hypertension in DOCA-salt-treated rats.

    abstract：:To determine whether baroreflex is changed centrally before the development of hypertension in DOCA-salt treated rats, aortic depressor nerve was stimulated electrically 5 days after DOCA-salt treatment in urethane-anesthetized rats: compared with those of sham-operated control rats, blood pressure was not elevated in...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.3.23s

    authors： Takeda K,Nakamura Y,Oguro M,Kawasaki S,Hayashi J,Tanabe S,Nakata T,Lee LC,Sasaki S,Nakagawa M

    更新日期：1988-07-01 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract：BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpy111

    authors： Simons AN,Moreland CJ,Kushalnagar P

    更新日期：2018-10-15 00:00:00