Ionized magnesium and calcium levels in umbilical cord serum of pregnant women with transient hypertension during labor.

Abstract:

:Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotensive. Ionized, but not total magnesium levels were significantly lower in the umbilical veins of the hypertensive compared to the normotensive subjects (0.46 +/- 0.01 v 0.51 +/- 0.01 mmol/L), and these were at least 15% lower than maternal levels found in nonpregnant women (0.60 +/- 0.005 mmol/L, P < .001). If umbilical vein samples reflect maternal levels as well, then these results suggest that lower IMg2+ levels may play a role in the development of transient hypertension in labor, and the potential utility of an ion selective electrode for ionized magnesium in the diagnosis of subtle magnesium deficient states.

journal_name

Am J Hypertens

authors

Handwerker SM,Altura BT,Royo B,Altura BM

doi

10.1093/ajh/6.6.542

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

542-5

issue

6 Pt 1

eissn

0895-7061

issn

1941-7225

pii

0895-7061(93)90180-T

journal_volume

6

pub_type

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