Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.

abstract：:Recently, we described a circulating hypertensive factor, present in the plasma of spontaneously hypertensive rats (SHR). This factor seems to be produced by the parathyroid gland but is not identical to parathyroid hormone (PTH). In view of these findings, we attempted to search for histological differences in parath...

journal_title：American journal of hypertension

authors： Kaneko T,Ohtani R,Lewanczuk RZ,Pang PK

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cell...

journal_title：American journal of hypertension

authors： Ding XF,Sun M,Guan FX,Guo LN,Zhang YY,Wan YD,Zhang XJ,Yu YW,Ma SS,Yao HM,Yao R,Zhang RF,Sun TW,Kan QC

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...

journal_title：American journal of hypertension

authors： Wakabayashi I

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Although insulin resistance and metabolic syndrome are often used synonymously, concordance is not established. METHODS:Metabolic, hemodynamic, and hormonal data were analyzed on 141 patients in the Trial of Preventing Hypertension (TROPHY) Sub-Study with high-normal blood pressure (BP) (130 to 139/85 to 89...

journal_title：American journal of hypertension

authors： Egan BM,Papademetriou V,Wofford M,Calhoun D,Fernandes J,Riehle JE,Nesbitt S,Michelson E,Julius S,TROPHY Sub-study Investigative Team.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic s...

journal_title：American journal of hypertension

authors： Janson JJ,Galarza CR,Murúa A,Quintana I,Przygoda PA,Waisman G,Camera L,Kordich L,Morales M,Mayorga LM,Camera MI

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

journal_title：American journal of hypertension

authors： Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:The association of adiposity during childhood with future risk of elevated blood pressure (BP) in South Asian children is not known. We aimed to investigate the relationship between waist circumference (WC) and body mass index (BMI) with BP over a 2-year period, independent of the baseline BP. METHODS:We an...

journal_title：American journal of hypertension

authors： Almas A,Jafar TH

更新日期：2011-08-01 00:00:00

abstract：:This study was designed to analyze the cardiac effects of aging and of hypertension in patients with essential hypertension and with or without left ventricular hypertrophy (LVH). Thirty-one patients <55 years old and 66 patients >64 years old with essential hypertension were divided according to the presence or absen...

journal_title：American journal of hypertension

authors： Grodzicki T,Michalewicz L,Messerli FH

更新日期：1998-04-01 00:00:00

abstract：:In normal subjects, insulin decreases the urinary excretion of sodium, potassium, and uric acid. We tested whether these renal effects of insulin are altered in insulin resistant hypertension. In 37 patients with essential hypertension, we measured the changes in urinary excretion of sodium, potassium, and uric acid i...

journal_title：American journal of hypertension

authors： Muscelli E,Natali A,Bianchi S,Bigazzi R,Galvan AQ,Sironi AM,Frascerra S,Ciociaro D,Ferrannini E

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. METHODS:We studied healthy untreated patients with obstructive sleep apnea (18 se...

journal_title：American journal of hypertension

authors： Winnicki M,Shamsuzzaman A,Lanfranchi P,Accurso V,Olson E,Davison D,Somers VK

更新日期：2004-09-01 00:00:00

abstract：:In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the v...

journal_title：American journal of hypertension

authors： Losito A,Fagugli RM,Zampi I,Parente B,de Rango P,Giordano G,Cao P

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...

journal_title：American journal of hypertension

authors： Hill LK,Sherwood A,Blumenthal JA,Hinderliter AL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In chronic kidney disease, intensive systolic blood pressure (SBP) control reduces mortality at a cost of greater acute kidney injury risk. Kidney transplantation involves implantation of denervated kidneys and immunosuppressive medications that increase acute kidney injury risk. The optimal blood pressure (...

journal_title：American journal of hypertension

authors： Malhotra R,Katz R,Weiner DE,Levey AS,Cheung AK,Bostom AG,Ix JH

更新日期：2019-08-14 00:00:00

abstract：:Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficien...

journal_title：American journal of hypertension

authors： George EM,Granger JP

更新日期：2011-09-01 00:00:00

abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...

journal_title：American journal of hypertension

authors： Tsuda K,Tsuda S,Nishio I,Masuyama Y,Goldstein M

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...

journal_title：American journal of hypertension

authors： Todd AS,Walker RJ,MacGinley RJ,Kelly J,Merriman TR,Major TJ,Johnson RJ

更新日期：2017-11-06 00:00:00

abstract：:Antihypertensive treatment is known to slow down the decline in glomerular filtration rate (GFR) with time. Angiotensin converting enzyme (ACE) inhibition has been shown to be more effective in this regard than conventional antihypertensive therapy. In a recent prospective, randomized, double blind trial in 257 patien...

journal_title：American journal of hypertension

authors： Himmelmann A,Hansson L,Hansson BG,Hedstrand H,Skogström K,Ohrvik J,Furängen A

更新日期：1996-09-01 00:00:00

abstract：:Angiotensin II (AII) has many potential effects on blood pressure regulation in addition to direct vasoconstriction. This study tested the hypothesis that minimally pressor infusions of AII, which themselves exert minimal effects on blood pressure, might significantly perturb the pressure response to hypertonic volume...

journal_title：American journal of hypertension

authors： Goldsmith SR

更新日期：1994-08-01 00:00:00

abstract：:Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

journal_title：American journal of hypertension

authors： Mahoney LT,Clarke WR,Burns TL,Lauer RM

更新日期：1991-11-01 00:00:00

abstract：:Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...

journal_title：American journal of hypertension

authors： Black HR

更新日期：1998-01-01 00:00:00

abstract：:The effect of fish oil on potassium efflux and basal tension in aortas from stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Four-week-old male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean syst...

journal_title：American journal of hypertension

authors： Smith JM,Paulson DJ,Labak S

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enroll...

journal_title：American journal of hypertension

authors： DeLoach SS,Appel LJ,Chen J,Joffe MM,Gadegbeku CA,Mohler ER 3rd,Parsa A,Perumal K,Rafey MA,Steigerwalt SP,Teal V,Townsend RR,Rosas SE

更新日期：2009-12-01 00:00:00

abstract：:The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...

journal_title：American journal of hypertension

authors： Vacher E,Fornes P,Domergue V,Richer C,Bruneval P,Giudicelli JF

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:It is not clear which educational strategy is most effective in helping patients to change their lifestyles. This study compared the efficacy of two different educational models on reducing blood pressure (BP). METHODS:This was a randomized controlled trial in ambulatory hypertensive patients >65 years of a...

journal_title：American journal of hypertension

authors： Figar S,Galarza C,Petrlik E,Hornstein L,Rodríguez Loria G,Waisman G,Rada M,Soriano ER,de Quirós FG

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Hypertension is the most prevalent chronic disease worldwide. Lifestyle behaviors for its prevention and control are recommended within worldwide guidelines. Nevertheless, their combined relationship with blood pressure (BP) level, particularly in the general population, would need more investigations. Our a...

journal_title：American journal of hypertension

authors： Lelong H,Galan P,Kesse-Guyot E,Fezeu L,Hercberg S,Blacher J

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patient...

journal_title：American journal of hypertension

authors： Kario K,Ito S,Itoh H,Rakugi H,Okuda Y,Yoshimura M,Yamakawa S

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal bloo...

journal_title：American journal of hypertension

authors： Kasahara A,Adachi H,Hirai Y,Enomoto M,Fukami A,Yoshikawa K,Esaki E,Yokoi K,Ogata K,Tsukagawa E,Obuchi A,Yoshimura A,Nakamura S,Imaizumi T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

journal_title：American journal of hypertension

authors： Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

journal_title：American journal of hypertension

authors： Notarius CF,Morris BL,Floras JS

更新日期：2006-02-01 00:00:00

abstract：:Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urin...

journal_title：American journal of hypertension

authors： Burgess ED,Hawkins RG,Watanabe M

更新日期：1990-12-01 00:00:00