Angiotensin II potentiates the arterial pressure response to volume loading in humans.


:Angiotensin II (AII) has many potential effects on blood pressure regulation in addition to direct vasoconstriction. This study tested the hypothesis that minimally pressor infusions of AII, which themselves exert minimal effects on blood pressure, might significantly perturb the pressure response to hypertonic volume expansion in healthy humans. Accordingly, 3% saline was infused at 0.1 mL/kg/min in 13 healthy volunteers, both with and without concomitant AII infusion (2 ng/kg/min) on separate days. On a third day, AII was infused alone for 2 h in eight of these subjects. Eight subjects also were studied with 3% saline plus concomitant phenylephrine infusion as a "positive control." AII and phenylephrine exerted similar, small effects on mean arterial pressure (3.3 +/- 1.5 v 3.0 +/- 1.0 mm Hg, P = NS) before the infusion of AII. When 3% saline was infused alone, mean arterial pressure did not rise significantly. In the presence of AII, mean arterial pressure rose from 89 +/- 10 to 97 +/- 11 mm Hg (P < .01 v control; P < .05 v 3% saline alone). In the presence of phenylephrine, the mean arterial pressure did not increase during 3% saline infusion, similar to the results during 3% saline infusion alone. Plasma osmolality and arginine vasopressin levels were not different during 3% saline infusions with and without AII or with phenylephrine. Thus, a minimally pressor infusion of AII significantly potentiated the response of mean arterial pressure to hypertonic volume expansion in healthy humans.(ABSTRACT TRUNCATED AT 250 WORDS)


Am J Hypertens


Goldsmith SR




Has Abstract


1994-08-01 00:00:00














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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Funck KL,Laugesen E,Høyem P,Fleischer J,Cichosz SL,Christiansen JS,Hansen TK,Poulsen PL

    更新日期:2016-07-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


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    更新日期:1998-01-01 00:00:00

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    更新日期:2010-10-01 00:00:00

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    更新日期:2010-03-01 00:00:00

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    journal_title:American journal of hypertension

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    更新日期:2005-03-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gosse P,Desrumeau GC,Roudaut R,Broustet JP,Dallocchio M

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    更新日期:2013-08-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Musso NR,Giacchè M,Galbariggi G,Vergassola C

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    journal_title:American journal of hypertension

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    更新日期:2005-11-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shultz PJ,Raij L

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1988-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Vacher E,Fornes P,Domergue V,Richer C,Bruneval P,Giudicelli JF

    更新日期:1993-11-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


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    更新日期:2002-10-01 00:00:00

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    abstract:BACKGROUND:The presence of asymptomatic left ventricular diastolic dysfunction (LVDD) in hypertensive patients can be associated with the development of cardiac events. The increase in sympathetic activity may be 1 of the mechanisms that predisposes to this outcome. In this study, we analyzed 2 hypotheses: (i) whether ...

    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


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    更新日期:2004-10-01 00:00:00

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    journal_title:American journal of hypertension

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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