Renal tissue kallikrein in newborn and young SHR.

abstract：:Platelet intracellular free calcium concentration [Ca2+]i from patients with essential hypertension has been found to be elevated, but the intracellular effects of this increase are still unclear. As protein phosphorylation is an important regulatory step in cell activation and increased protein phosphorylation has be...

journal_title：American journal of hypertension

authors： Haller H,Lindschau C,Quass P,Distler A

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors have been widely used in the treatment of hypertension, but the comparative effectiveness in reducing mortality among different drugs is seldom reported. METHODS:We identified hypertensive patients who started captopril, enalapril, lisinopril, fosinopril, perin...

journal_title：American journal of hypertension

authors： Chang CH,Lin JW,Caffrey JL,Wu LC,Lai MS

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling by statins increases the activity of endothelial nitric oxide synthase (eNOS). We investigate whether statins (pitavastatin) improve cardiac function and remodeling via eNOS production associated with the PI3K-Akt signaling pathway, Rho-kinase ...

journal_title：American journal of hypertension

authors： Kobayashi N,Takeshima H,Fukushima H,Koguchi W,Mamada Y,Hirata H,Machida Y,Shinoda M,Suzuki N,Yokotsuka F,Tabei K,Matsuoka H

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The optimal schedule for self-monitoring home BP (SMHBP) readings is enormously important in the diagnosis of different phenotypes related to hypertension. The aim of this study was to determine the prognostic capacity of a 3-day SMHBP schedule when using or suppressing the first-day measurements in compilin...

journal_title：American journal of hypertension

authors： Bayó J,Dalfó A,Barceló MA,Saez M,Roca C,Pallozzi J,Coll-De-Tuero G

更新日期：2020-02-22 00:00:00

abstract：:The influence of increased lability of blood pressure on the development of aortic atherosclerosis was examined. Because sinoaortic denervation (SAD) produced increased lability of blood pressure without blood pressure elevation, the development of atheromatous plaque was examined in SAD rats. These rats were fed a hi...

journal_title：American journal of hypertension

authors： Sasaki S,Yoneda Y,Fujita H,Uchida A,Takenaka K,Takesako T,Itoh H,Nakata T,Takeda K,Nakagawa M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs) increase arterial compliance and decrease left ventricular mass in hypertensive patients. This study examined whether combined therapy has greater arterial and cardiac effects than doubled doses of the individual drugs. METHO...

journal_title：American journal of hypertension

authors： Neutel JM,Smith DH,Weber MA

更新日期：2004-01-01 00:00:00

abstract：:We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activatio...

journal_title：American journal of hypertension

authors： Xiao J,Pang PK

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...

journal_title：American journal of hypertension

authors： Franceschini N,MacCluer JW,Rose KM,Rutherford S,Cole SA,Laston S,Göring HH,Diego VP,Roman MJ,Lee ET,Best LG,Howard BV,Fabsitz RR,North KE

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The efficacy and safety of angiotensin receptor blockers (ARBs) in the older population is unclear. OBJECTIVES:To determine the efficacy and safety of ARBs in older patients. METHODS:Randomized trials that compared ARBs to control and reported clinical outcomes in patients with a mean age of 65 years or ol...

journal_title：American journal of hypertension

authors： Elgendy IY,Huo T,Chik V,Pepine CJ,Bavry AA

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Subjects with resistant hypertension present high prevalence of a nondipper blood pressure (BP) pattern, associated with increased risk of cardiovascular events. Nondipping is partly related to the absence of 24-h therapeutic coverage in hypertensives treated with single morning doses. METHODS:We studied th...

journal_title：American journal of hypertension

authors： Hermida RC,Ayala DE,Mojón A,Fernández JR

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. The present study was conducted to clarify whether the IR is more closely related to the macrovasculature...

journal_title：American journal of hypertension

authors： Yoshida M,Tomiyama H,Yamada J,Matsumoto C,Odaira M,Shiina K,Yamashina A

更新日期：2010-05-01 00:00:00

abstract：:A negative calcium balance has previously been described in human hypertension with low levels of plasma ionized calcium (Ca2+) and an increased urinary excretion of calcium. The cause of this disturbance in mineral metabolism is not known, nor is it known if this derangement could be abolished if blood pressure is re...

journal_title：American journal of hypertension

authors： Lind L,Hänni A,Hvarfner A,Pollare T,Ljunghall S,Lithell H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:It is unknown whether the physiological impact of a given blood pressure (BP) varies by body size. We explored interactions between higher vs. lower systolic BP (SBP) targets and anthropometric measures (body mass index (BMI), body surface area (BSA), height, weight) and recurrent stroke and death in the Sec...

journal_title：American journal of hypertension

authors： Field TS,McClure LA,White CL,Pergola PE,Hart RG,Benavente OR,Hill MD,SPS3 Investigators.

更新日期：2015-06-01 00:00:00

abstract：:Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-D...

journal_title：American journal of hypertension

authors： Keen HL,Brands MW,Alonso-Galicia M,Hall JE

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enroll...

journal_title：American journal of hypertension

authors： DeLoach SS,Appel LJ,Chen J,Joffe MM,Gadegbeku CA,Mohler ER 3rd,Parsa A,Perumal K,Rafey MA,Steigerwalt SP,Teal V,Townsend RR,Rosas SE

更新日期：2009-12-01 00:00:00

abstract：:Experimental research using in vitro and in vivo models of vascular injury have delineated several common mechanisms that characterize the arterial damage in diseases such as atherosclerosis and hypertension. Changes in endothelial permeability, smooth muscle cell proliferation, and accumulation of connective tissue m...

journal_title：American journal of hypertension

authors： Weinstein DB,Heider JG

更新日期：1989-03-01 00:00:00

abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

journal_title：American journal of hypertension

authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patient...

journal_title：American journal of hypertension

authors： Kario K,Ito S,Itoh H,Rakugi H,Okuda Y,Yoshimura M,Yamakawa S

更新日期：2020-11-09 00:00:00

abstract：OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

journal_title：American journal of hypertension

authors： Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

更新日期：2019-06-11 00:00:00

abstract：:Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled, uncontrolled study was initiated in o...

journal_title：American journal of hypertension

authors： Shieh SM,Sheu WH,Shen DD,Fuh MM,Jeng CY,Jeng JR,Chen YD,Reaven GM

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:We postulated that acute hypoxemia increases susceptibility to orthostatic hypotension by increasing the sensitivity of cardiovascular baroreceptors. METHODS:Hemodynamics were measured noninvasively in 17 healthy, normotensive subjects while being subjected to decreasing venous return by exposure to lower b...

journal_title：American journal of hypertension

authors： Fox WC,Watson R,Lockette W

更新日期：2006-09-01 00:00:00

abstract：:Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP con...

journal_title：American journal of hypertension

authors： Jin HK,Yang RH,Chen YF,Wyss JM,Oparil S

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. The present study was aimed to investigate hemodynamic factors that are...

journal_title：American journal of hypertension

authors： Hsu PF,Cheng HM,Sung SH,Chuang SY,Lakatta EG,Yin FC,Chou P,Chen CH

更新日期：2017-03-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

journal_title：American journal of hypertension

authors： Kostis JB

更新日期：1989-01-01 00:00:00

abstract：:Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

journal_title：American journal of hypertension

authors： Mahoney LT,Clarke WR,Burns TL,Lauer RM

更新日期：1991-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...

journal_title：American journal of hypertension

authors： Schiffrin EL

更新日期：2001-06-01 00:00:00

abstract：:We studied how closely changes in electronically monitored physical activity are reflected in changes in blood pressure and heart rate in a group of untreated hypertensive subjects. Thirty-nine hypertensive patients (office blood pressure > 140/ 90 mm Hg) of mean age 57 +/- 10 years (mean +/-SD) wore an ambulatory blo...

journal_title：American journal of hypertension

authors： Mansoor GA,White WB,McCabe EJ,Giacco S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Obese and overweight patients are at increased risk of arterial stiffness, and visceral, epicardial and hepatic fat accumulation is associated with cardiovascular disease risk. In general, muscular lipids are stored either in interstitial adipose tissue (extramyocellular lipid (EMCL)) or in lipid droplets wi...

journal_title：American journal of hypertension

authors： Hasegawa N,Kurihara T,Sato K,Homma T,Fujie S,Fujita S,Sanada K,Hamaoka T,Iemitsu M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that tamoxifen, which belongs to a group called selective estrogen receptor modulators (SERM), may exert protective effects against cardiovascular diseases and stroke in postmenopausal women. On the other hand, abnormalities in physical properties of the cell membranes may underlie ...

journal_title：American journal of hypertension

authors： Tsuda K,Nishio I

更新日期：2005-08-01 00:00:00

abstract：:This multicenter, randomized, controlled clinical trial assessed the influence of sodium chloride intake on the antihypertensive effect of the calcium channel blocker isradipine. Participants with uncomplicated hypertension controlled by isradipine entered a 4-week sodium-restricted (60 to 80 mmol/24 h) period. Partic...

journal_title：American journal of hypertension

authors： McCarron DA,Weder AB,Egan BM,Krishna GG,Morris CD,Cohen M,Oparil S

更新日期：1997-01-01 00:00:00