当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.

Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.

Abstract：

BACKGROUND:Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases. METHOD:This study compares oxidative stress (OS) in Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), non-insulin-dependent Cohen Diabetic rats (CDR), and Cohen Rosenthal diabetic hypertensive rats (CRDH), a unique animal model of both diabetes and hypertension. The OS was evaluated with a newly developed thermochemiluminiscence (TCL) analyzer (Lumitest Ltd., Nesher, Israel) that measures the oxidizability (ie, susceptibility to oxidation) of a test sample. RESULTS:The TCL oxidizability test results of sera from the different rats groups showed a time-dependent increase in TCL of up to 145% +/- 7% for WKY, 160% +/- 8% for SHR, 179% +/- 12% for CDR, and 226% +/- 15% for CRDH. These results were significant: P <.001 for SHR and CDR and P <.0001 for CRDH in comparison to WKY. Lipid peroxide levels also increased in each strain of rats: to 80 +/- 7.8 nmol/mL in WKY, 104 +/- 10.1 nmol/mL in SHR, 110 +/- 9.4 nmol/mL in CDR, and 167 +/- 11.7 nmol/mL in CRDH. These results were also significant: P <.001 for SHR, CDR and CRDH in comparison to WKY. CONCLUSION:The combination of hypertension and diabetes is accompanied by higher oxidative stress than that seen with either disorder alone.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Friedman J,Peleg E,Kagan T,Shnizer S,Rosenthal T

doi

10.1016/j.amjhyper.2003.07.013

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1049-52

issue

12

eissn

0895-7061

issn

1941-7225

pii

S0895706103010756

journal_volume

16

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Does the augmentation index of pulse waves truly increase with progression of atherosclerosis? An experimental study with hypercholesterolemic rabbits.

    abstract：BACKGROUND:Recently, the central augmentation index (AIx) has been reported to show a nonlinear correlation with age. We investigated whether the AIx of the central artery changes with the progression of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. METHODS:We simultaneously recorded pre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hps037

    authors： Katsuda S,Miyake M,Kobayashi D,Hazama A,Kusanagi M,Takazawa K

    更新日期：2013-03-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract：:The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.16

    authors： Ruilope LM,Schmieder RE

    更新日期：2008-05-01 00:00:00

  • Autonomic imbalance, hypertension, and cardiovascular risk.

    abstract：:Essential hypertension conveys an increased risk of cardiovascular morbidity and mortality. The common finding of an autonomic imbalance in these patients contributes not only to the etiology of hypertension itself, but also to the cardiac risk and resulting adverse sequelae. A high sympathetic tone in particular is r...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(00)00228-4

    authors： Brook RD,Julius S

    更新日期：2000-06-01 00:00:00

  • Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study.

    abstract：BACKGROUND:It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS:In the ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2010.89

    authors： Wiik BP,Larstorp AC,Høieggen A,Kjeldsen SE,Olsen MH,Ibsen H,Lindholm L,Dahlöf B,Devereux RB,Okin PM,Wachtell K

    更新日期：2010-08-01 00:00:00

  • Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension.

    abstract：BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)02967-9

    authors： Galderisi M,Caso P,Cicala S,De Simone L,Barbieri M,Vitale G,de Divitiis O,Paolisso G

    更新日期：2002-09-01 00:00:00

  • New approaches to screening for vascular and cardiac risk.

    abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02092-1

    authors： Cohn JN

    更新日期：2001-06-01 00:00:00

  • Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.

    abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity in hypertension. Current evidence suggests a contribution to LVH of plasma aldosterone levels that are inappropriately elevated for the salt status. The aim of this study was to investigate whether inappropriate mod...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv104

    authors： Catena C,Verheyen ND,Url-Michitsch M,Kraigher-Krainer E,Colussi G,Pilz S,Tomaschitz A,Pieske B,Sechi LA

    更新日期：2016-03-01 00:00:00

  • Post-transplant hypertension.

    abstract：:Post-transplant hypertension remains an important risk factor for cardiovascular mortality and graft function. There are multiple mechanisms responsible for post-transplant hypertension. The details of these mechanisms are poorly understood. Steroids, acute and chronic rejection, recurrent renal disease, native kidney...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/3.9.721

    authors： Laskow DA,Curtis JJ

    更新日期：1990-09-01 00:00:00

  • Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice.

    abstract：BACKGROUND:Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)-induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpt095

    authors： Jiang HM,Wang HX,Yang H,Zeng XJ,Tang CS,Du J,Li HH

    更新日期：2013-10-01 00:00:00

  • Angiotensin-converting enzyme inhibitors. Emerging differences and new compounds.

    abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.1.57

    authors： Kostis JB

    更新日期：1989-01-01 00:00:00

  • Sleep apnea, hypertension, and the effects of continuous positive airway pressure.

    abstract：BACKGROUND:Sleep apnea is being studied as a risk factor for hypertension. This observational chart review was conducted to determine the long-term effects of continuous positive airway pressure (CPAP) treatment on blood pressure (BP) in a sample of sleep apnea patients from urban and rural populations. METHODS:This s...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.11.031

    authors： Dhillon S,Chung SA,Fargher T,Huterer N,Shapiro CM

    更新日期：2005-05-01 00:00:00

  • Neural control of renin release.

    abstract：:Among the major mechanisms controlling the renal release of renin, renal nerves are known to exert a direct stimulating action on juxtaglomerular cells that is mediated by beta-adrenoceptors. Activation of the renal nerves also exerts an important permissive role in order to amplify and possibly accelerate responses t...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.2.7s

    authors： Stella A,Golin R,Zanchetti A

    更新日期：1989-02-01 00:00:00

  • Metabolic syndrome and insulin resistance in the TROPHY sub-study: contrasting views in patients with high-normal blood pressure.

    abstract：BACKGROUND:Although insulin resistance and metabolic syndrome are often used synonymously, concordance is not established. METHODS:Metabolic, hemodynamic, and hormonal data were analyzed on 141 patients in the Trial of Preventing Hypertension (TROPHY) Sub-Study with high-normal blood pressure (BP) (130 to 139/85 to 89...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.08.008

    authors： Egan BM,Papademetriou V,Wofford M,Calhoun D,Fernandes J,Riehle JE,Nesbitt S,Michelson E,Julius S,TROPHY Sub-study Investigative Team.

    更新日期：2005-01-01 00:00:00

  • Are there meaningful differences in blood pressure control with current antihypertensive agents?

    abstract：:Hypertension is a major risk factor for cardiovascular disease, and small reductions in blood pressure can have a substantial impact on outcome. Effective control of hypertension per se is important in reducing morbidity and mortality, but there is growing evidence that the class of drug used in treatment may affect p...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02272-5

    authors： Oparil S

    更新日期：2002-01-01 00:00:00

  • Validity of plasma aldosterone-to-renin activity ratio in African American and white subjects with resistant hypertension.

    abstract：BACKGROUND:Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.01.002

    authors： Nishizaka MK,Pratt-Ubunama M,Zaman MA,Cofield S,Calhoun DA

    更新日期：2005-06-01 00:00:00

  • Intramyocellular and Extramyocellular Lipids Are Associated With Arterial Stiffness.

    abstract：BACKGROUND:Obese and overweight patients are at increased risk of arterial stiffness, and visceral, epicardial and hepatic fat accumulation is associated with cardiovascular disease risk. In general, muscular lipids are stored either in interstitial adipose tissue (extramyocellular lipid (EMCL)) or in lipid droplets wi...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv041

    authors： Hasegawa N,Kurihara T,Sato K,Homma T,Fujie S,Fujita S,Sanada K,Hamaoka T,Iemitsu M

    更新日期：2015-12-01 00:00:00

  • Acculturation is associated with hypertension in a multiethnic sample.

    abstract：BACKGROUND:Hypertension varies in prevalence among race/ethnic groups in the United States. Within-ethnic group differences associated with acculturation have been less frequently examined. We studied the association of three measures of acculturation (language spoken at home, place of birth, and years living in the US...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.09.025

    authors： Moran A,Diez Roux AV,Jackson SA,Kramer H,Manolio TA,Shrager S,Shea S

    更新日期：2007-04-01 00:00:00

  • Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

    abstract：BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpu016

    authors： Hye Khan MA,Neckář J,Haines J,Imig JD

    更新日期：2014-08-01 00:00:00

  • Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.

    abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.278

    authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

    更新日期：2008-11-01 00:00:00

  • Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents.

    abstract：:The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensity of these disorders to manifest depression has not been reported. In this study, the LH behavio...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00271-x

    authors： Edwards E,King JA,Fray J

    更新日期：2000-06-01 00:00:00

  • Interdependence of blood pressure and heart period regulation in mild hypertension.

    abstract：:Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.3.234

    authors： Coats AJ,Conway J,Sleight P,Meyer TE,Somers VK,Floras JS,Vann Jones J

    更新日期：1991-03-01 00:00:00

  • How to explain the differences between renin angiotensin system modulators.

    abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/j.amjhyper.2005.05.005

    authors： Levy BI

    更新日期：2005-09-01 00:00:00

  • Effect of short-term antihypertensive therapy on left ventricular wall tension. A double-blind comparison of isradipine and nifedipine.

    abstract：:The comparative efficacy of the calcium antagonists isradipine and nifedipine in reducing left ventricular peak systolic wall tension was assessed in 25 patients with essential hypertension (20 men, 5 women; mean age: 49 years). After 2 weeks of treatment with either isradipine (2.5 mg twice daily) or slow-release nif...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/6.3.92s

    authors： Griebenow R,Müller R,Steffen HM,Burger KJ,Welzel D

    更新日期：1993-03-01 00:00:00

  • Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study.

    abstract：BACKGROUND:Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. METHODS:Brachial-ankle PWV (b...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2007.77

    authors： Ishikawa T,Hashimoto J,Morito RH,Hanazawa T,Aikawa T,Hara A,Shintani Y,Metoki H,Inoue R,Asayama K,Kikuya M,Ohkubo T,Totsune K,Hoshi H,Satoh H,Imai Y

    更新日期：2008-04-01 00:00:00

  • A selective estrogen receptor modulator, tamoxifen, and membrane fluidity of erythrocytes in normotensive and hypertensive postmenopausal women: an electron paramagnetic resonance investigation.

    abstract：BACKGROUND:Recent studies have shown that tamoxifen, which belongs to a group called selective estrogen receptor modulators (SERM), may exert protective effects against cardiovascular diseases and stroke in postmenopausal women. On the other hand, abnormalities in physical properties of the cell membranes may underlie ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.02.009

    authors： Tsuda K,Nishio I

    更新日期：2005-08-01 00:00:00

  • Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide.

    abstract：BACKGROUND:Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.amjhyper.2004.10.021

    authors： Finkielman JD,Schwartz GL,Chapman AB,Boerwinkle E,Turner ST

    更新日期：2005-03-01 00:00:00

  • New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

    abstract：BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...

    journal_title：American journal of hypertension

    pub_type：

    doi：10.1093/ajh/hpz125

    authors： Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

    更新日期：2019-11-15 00:00:00

  • Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.

    abstract：:The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.7.50s

    authors： Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

    更新日期：1994-07-01 00:00:00

  • Left ventricular mass in normotensive subjects. Importance of blood pressure response to activity.

    abstract：:Recent works have shown the importance of blood pressure (BP) response to exercise or to daily activity as determinants of hypertensive cardiac hypertrophy. We have tested the relationship between BP and left ventricular (LV) mass in 23 normotensive young adults (mean age 25 +/- 5) with normotensive parents. Blood pre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.2.78

    authors： Gosse P,Desrumeau GC,Roudaut R,Broustet JP,Dallocchio M

    更新日期：1989-02-01 00:00:00

  • Relationship Between Dynamic Changes in Body Weight and Blood Pressure: The ESTEBAN Survey.

    abstract：BACKGROUND:Obesity is one of the main determinants of blood pressure. The aim of this study was to evaluate and quantify the relations between the different anthropometric indices and blood pressure (BP) stratified by gender. METHODS:Cross-sectional analyses were performed using data from 2,105 adults from the ESTEBAN...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpz096

    authors： Vallée A,Perrine AL,Deschamps V,Blacher J,Olié V

    更新日期：2019-09-24 00:00:00