Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.


:The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, as these vessels are partly responsible for the regulation of uteroplacental blood flow in preeclampsia. Small myometrial arteries were dissected from myometrium obtained from 20 normotensive term pregnant women undergoing elective cesarean section and mounted in a tissue chamber. Tension was recorded isometrically. When ET-1 (10(-8) mol/L)-contracted vessels were exposed to increasing concentrations (10(-6), 10(-5), and 10(-4) mol/L) of isradipine, the myometrial arteries demonstrated essentially no relaxation. A significant mean relaxation of 31% was seen only with the highest isradipine concentration of 10(-3) mol/L. Pretreatment with isradipine attenuated ET-1-induced contraction by 26% at 3 x 10(-4) mol/L and by up to 80% at 10(-3) mol/L. Preincubation with lower concentrations of isradipine did not significantly reduce subsequent ET-1 contraction. The present study has thus shown that isradipine at high concentrations counteracts ET-1-induced constriction of myometrial arteries in term pregnant women. Pretreatment with isradipine at high concentrations attenuates the ET-1 contraction.


Am J Hypertens


Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H




Has Abstract


1994-07-01 00:00:00




7 Pt 2










  • The influence of physical activity on the variability of ambulatory blood pressure.

    abstract::The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Leary AC,Donnan PT,MacDonald TM,Murphy MB

    更新日期:2000-10-01 00:00:00

  • Renal denervation decreases blood pressure in DOCA-treated miniature swine with established hypertension.

    abstract::The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: O'Hagan KP,Thomas GD,Zambraski EJ

    更新日期:1990-01-01 00:00:00

  • Left ventricular hypertrophy and angiotensin II antagonists.

    abstract::Left ventricular hypertrophy in patients with hypertension is an important condition. It is associated with significant mortality and carries increased risk for developing nonfatal cardiovascular complications, including coronary heart disease. The pathogenesis of left ventricular hypertrophy is linked to activation o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Dahlöf B

    更新日期:2001-02-01 00:00:00

  • History of antihypertensive therapy influences the relationships of alcohol with blood pressure and pulse pressure in older men.

    abstract:BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wakabayashi I

    更新日期:2010-06-01 00:00:00

  • Relationship among end-stage renal disease, hypertension, and sleep apnea in nondiabetic dialysis patients.

    abstract:BACKGROUND:Cardiovascular diseases (CVD) are responsible for more than 50% of the deaths in patients with end-stage renal disease (ESRD). Sleep apnea (SA) has been recognized as a risk factor for CVD. Previous studies have shown a higher prevalence of SA among patients on dialysis. METHODS:Forty-five nondiabetics pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: de Oliveira Rodrigues CJ,Marson O,Tufic S,Kohlmann O Jr,Guimarães SM,Togeiro P,Ribeiro AB,Tavares A

    更新日期:2005-02-01 00:00:00

  • Platelet and erythrocyte membrane microviscosity in Lyon hypertensive rats.

    abstract::The altered membrane microviscosity demonstrated in various cells of spontaneously hypertensive rats (SHR) and essential hypertensive (EH) patients has been proposed to play an important role in the pathogenesis of genetic forms of hypertension. The aim of this study was to evaluate possible changes of membrane microv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Le Quan Sang KH,Kunes J,Zicha J,Vincent M,Sassard J,Devynck MA

    更新日期:1994-03-01 00:00:00

  • Masked hypertension in the elderly: cross-sectional analysis of a population-based sample.

    abstract:BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cacciolati C,Hanon O,Alpérovitch A,Dufouil C,Tzourio C

    更新日期:2011-06-01 00:00:00

  • Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

    abstract::The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

    更新日期:2001-11-01 00:00:00

  • Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension.

    abstract:BACKGROUND:Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS:We recruited 178 patients with uncomplicated nondiabetic HT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chen JY,Chou CH,Lee YL,Tsai WC,Lin CC,Huang YY,Chen JH

    更新日期:2010-10-01 00:00:00

  • Body mass index is not independently associated with increased aortic stiffness in a Brazilian population.

    abstract:BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rodrigues SL,Baldo MP,Lani L,Nogueira L,Mill JG,Sa Cunha Rd

    更新日期:2012-10-01 00:00:00

  • Antihypertensive therapy and cardiovascular disease. Impact of effective therapy on disease progression.

    abstract::Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Black HR

    更新日期:1998-01-01 00:00:00

  • Ionized magnesium and calcium levels in umbilical cord serum of pregnant women with transient hypertension during labor.

    abstract::Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotens...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Handwerker SM,Altura BT,Royo B,Altura BM

    更新日期:1993-06-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract::The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ruilope LM,Schmieder RE

    更新日期:2008-05-01 00:00:00

  • Metabolic Syndrome and Cardiovascular Risk in Elderly Treated Hypertensive Patients.

    abstract:BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pierdomenico SD,Pierdomenico AM,Di Tommaso R,Coccina F,Di Carlo S,Cuccurullo F,Porreca E

    更新日期:2016-03-01 00:00:00

  • Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.

    abstract:BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Todd AS,Walker RJ,MacGinley RJ,Kelly J,Merriman TR,Major TJ,Johnson RJ

    更新日期:2017-11-06 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Enhanced neutrophil superoxide anion production and its modification by beraprost sodium in spontaneously hypertensive rats.

    abstract::To clarify the function of polymorphonuclear leukocytes (PMN) in spontaneously hypertensive rats (SHR) and the effect of beraprost sodium (BS) on these functions, we examined superoxide anion (O2-) production and adherent activity by PMN, as well as modification of these functions by BS ex vivo and in vitro. In study ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ohmori M,Kitoh Y,Kawaguchi A,Harada K,Sugimoto K,Fujimura A

    更新日期:2001-07-01 00:00:00

  • Association of arterial stiffness indexes, determined from digital volume pulse measurement and cardiovascular risk factors in chronic kidney disease.

    abstract:BACKGROUND:Progression of atherosclerosis with increased arterial stiffness is associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Compliance index (CI) derived from digital volume pulse (DVP), measuring the relationship between volume and pressure changes in ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wang MC,Wu AB,Cheng MF,Chen JY,Ho CS,Tsai WC

    更新日期:2011-05-01 00:00:00

  • Blood pressure circadian pattern and physical exercise assessment by accelerometer and 7-day physical activity recall scale.

    abstract:BACKGROUND:The relationship between regular physical activity, measured objectively and by self-report, and the circadian pattern of 24-hour ambulatory arterial blood pressure (BP) has not been clarified. METHODS:We performed a cross-sectional study in a cohort of healthy patients. We included 1,345 patients from the ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: García-Ortiz L,Recio-Rodríguez JI,Puig-Ribera A,Lema-Bartolomé J,Ibáñez-Jalón E,González-Viejo N,Guenaga-Saenz N,Agudo-Conde C,Patino-Alonso MC,Gomez-Marcos MA,EVIDENT Group.

    更新日期:2014-05-01 00:00:00

  • Impaired inotropic response in type 2 diabetes mellitus: a strain rate imaging study.

    abstract:BACKGROUND:Left ventricular (LV) concentric geometry and hypertrophy, depressed wall mechanics, and abnormal diastolic properties have been described in the diabetic heart. However, the cardiac response to dynamic exercise in diabetic patients remains controversial. The present study assessed strain rate (SR) imaging d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Galderisi M,de Simone G,Innelli P,Turco A,Turco S,Capaldo B,Riccardi G,de Divitiis O

    更新日期:2007-05-01 00:00:00

  • Antihypertensive effects of oral calcium supplementation may be mediated through the potent vasodilator CGRP.

    abstract::Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Wimalawansa SJ

    更新日期:1993-12-01 00:00:00

  • Association of blood pressure and cardiovascular mortality in India: Mumbai cohort study.

    abstract:BACKGROUND:To determine all-cause and circulatory system (cardiovascular)-related mortality in subjects with different grades of hypertension, we performed a prospective study. METHODS:A total of 148,173 individuals aged > or =35 years were recruited in Mumbai, India in years 1991-1997. Clinical history and anthropome...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pednekar MS,Gupta R,Gupta PC

    更新日期:2009-10-01 00:00:00

  • Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension.

    abstract::Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dominguez LJ,Barbagallo M,Jacober SJ,Jacobs DB,Sowers JR

    更新日期:1997-12-01 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract:BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Simons AN,Moreland CJ,Kushalnagar P

    更新日期:2018-10-15 00:00:00

  • Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension.

    abstract::Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Swislocki AL,Hoffman BB,Reaven GM

    更新日期:1989-06-01 00:00:00

  • Genetic Variation in SLC8A1 Gene Involved in Blood Pressure Responses to Acute Salt Loading.

    abstract:BACKGROUND:Salt sensitivity of blood pressure (SSBP) increases the risk of cardiovascular complications, and the heritability of SSBP is about 50% in Chinese population. However, studies identifying genes involved in BP responses to acute sodium loading and diuresis shrinkage are still limited. METHOD:A total of 342 e...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Liu K,Liu Z,Qi H,Liu B,Wu J,Liu Y,Zhang J,Cao H,Yan Y,He Y,Zhang L

    更新日期:2018-03-10 00:00:00

  • Diurnal blood pressure variation in kidney-pancreas transplant recipients.

    abstract::Blood pressure normally follows a characteristic pattern throughout the 24 h cycle with daytime pressures higher than nighttime pressures. Patients lacking a nocturnal decrease in pressure have a higher incidence of end organ damage. This investigation was designed to characterize the diurnal pattern of blood pressure...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Marx MA,Gardner SF,Ketel BL

    更新日期:1996-08-01 00:00:00

  • Effects of diabetes mellitus, pressure-overload and their association on myocardial structure and function.

    abstract:BACKGROUND:Structural and functional changes involved in cardiac injury induced by diabetes mellitus, pressure-overload, or both conditions were evaluated. METHODS:Pressure-overload was established by suprarenal aortic banding in rats. Six weeks later, diabetes was induced by streptozotocin (STZ, 65 mg/kg, intraperito...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Falcão-Pires I,Gonçalves N,Moura C,Lamego I,Eloy C,Lopes JM,Begieneman MP,Niessen HW,Areias JC,Leite-Moreira AF

    更新日期:2009-11-01 00:00:00

  • Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.

    abstract:BACKGROUND:Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofact...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mitchell BM,Cook LG,Danchuk S,Puschett JB

    更新日期:2007-12-01 00:00:00

  • Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study.

    abstract:BACKGROUND:It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS:In the ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Wiik BP,Larstorp AC,Høieggen A,Kjeldsen SE,Olsen MH,Ibsen H,Lindholm L,Dahlöf B,Devereux RB,Okin PM,Wachtell K

    更新日期:2010-08-01 00:00:00