Abstract:
BACKGROUND:Experimentally induced sleep deprivation can raise blood pressure (BP) and worsen hypertension. We recently reported a significantly higher prevalence of obstructive sleep apnea (OSA) and reduced rapid eye movement (REM) sleep time in drug-resistant hypertensives compared to controlled hypertensives. The objective of this study was to test the hypothesis that short sleep duration is associated with resistant hypertension (RH) independently of OSA, which can itself disrupt and shorten sleep. METHODS:In a case-control study, overnight polysomnographic results of subjects with OSA and RH (n = 62) were compared to those with OSA of equal severity and either controlled hypertension (CH) (n = 49) or normotension (n = 40). RESULTS:Subjects with RH slept 33.8 min (P = 0.02) and 37.2 min (P = 0.02) less than those with CH and normotension, respectively. Consequently, sleep efficiency was reduced by 7.9% (P = 0.007) and 10.2% (P = 0.002), respectively. They also spent 9.7 min (P = 0.06) and 11.6 min (P = 0.04) less time in REM sleep compared to those with CH and normotension, respectively. Older age, greater body mass index (BMI) and greater apnea-hypopnea index (AHI) were also associated with shorter sleep time (P = 0.02, P = 0.001, and P = 0.03, respectively) and reduced sleep efficiency (P = 0.0003, P = 0.03, and P = 0.01, respectively). CONCLUSIONS:Our study demonstrates that, compared to subjects with CH or normotension, those with RH have shorter total and REM sleep times and lower sleep efficiency independently of OSA. These data suggest that reduced sleep time may contribute to the severity of hypertension.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Friedman O,Bradley TD,Ruttanaumpawan P,Logan AGdoi
10.1038/ajh.2009.220subject
Has Abstractpub_date
2010-02-01 00:00:00pages
174-9issue
2eissn
0895-7061issn
1941-7225pii
ajh2009220journal_volume
23pub_type
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-07-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2001-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.5.449
更新日期:1991-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1988-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析
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更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.04.005
更新日期:2006-11-01 00:00:00