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Prevalence of hyperhomocysteinemia in an elderly population.

Abstract：

BACKGROUND:Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic studies of HHcy. PROCEDURE:Previously we described the prevalence of hypertension control in an elder population; now, in an observational cross-sectional simple blind study, total homocysteine (tHcy) concentration was determined in 196 of 400 patients from the original cohort. RESULTS:Mean Hcy concentration was 13.2 ,amol/L (95% confidence interval 12.4-14.0; range, 5.0 to 48.9); 15.0 ,imol/L for men and 12.3 pAmol/L for women. Mean serum folic acid levels were 4.9 + 3.1 ng/mL (range, 2.0 to 20.0 ng/mL), and vitamin B12 levels were 384.8 314.1 pg/mL (range, 48.0 to 1500.0 pg/mL). Taking into account the reference values established by the Third National Health and Nutrition Examination Survey III study, HHcy was detected in 69.8% of all the subjects evaluated. The study showed that 76.2% of the men and 66.4% of the women had high Hcy levels. CONCLUSIONS:The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Janson JJ,Galarza CR,Murúa A,Quintana I,Przygoda PA,Waisman G,Camera L,Kordich L,Morales M,Mayorga LM,Camera MI

doi

10.1016/s0895-7061(01)02165-3

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

394-7

issue

5

eissn

0895-7061

issn

1941-7225

pii

S0895706101021653

journal_volume

15

pub_type

杂志文章

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